Analysis of Nerve and Neuropeptide Patterns in Vacuum-Assisted Closure–Treated Diabetic Murine Wounds

Abstract

This study suggests that vacuum-assisted closure therapy can modulate nerve fiber and neuropeptide production in the wound. Optimized kinetics of vacuum-assisted closure application may provide an opportunity for clinicians to further improve wound healing in denervated wounds such as pressure sores and diabetic foot ulcerations.

Mast Cells Are Required in the Proliferation and Remodeling Phases of Microdeformational Wound Therapy

“…7 Wound closure analysis shows no significant difference between wild-type and WWv mice; this is explained by splinting of our wounds and the epithelialization contact inhibition effect of the foam material as published previously. 23 Mast cell activation early in the healing process is suggested to affect later collagen production and maturation. 6,12 Our findings proved that microdeformational wound therapy exhibited a significant increase in collagen production and a faster maturation of the wound matrix into a permanent durable collagen matrix.…”

“…A suction tube is then inserted and secured over the dressing and linked to the pump. 19,23 Dressing changes were performed on days 2, 4, 7, 10, and 14 after excision with digital photography for wound planimetry. On days 1, 2, 7, and 14, animals were killed, with tissue fixed in 10% neutral-buffered formalin solution and kept in 70% alcohol at 4°C until paraffin or JB-4 glycol methacrylate embedment.…”

Study on the effect of vacuum sealing drainage on the repair process of rabbit sciatic nerve injury

“…Improved microcirculation is known to promote nerve repair [11]; (2) VSD can promote the secretion of active substance of peripheral nerve, such as substance P, VEGF, platelet-derived growth factor (PDGF), transforming growth factor (TGF-β) [3,[12][13][14]. The role of the active substances including substance P, VEGF, PDGF.…”

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

“…Furthermore, negative pressure protocols are typically used at one of two settings, namely, continuous or intermittent. In one previous study, intermittent suction was observed to cause a more profound tissue response compared with conventional methods; however, this suction mode may cause discomfort and intolerability in patients (32). In the present study, continuous negative pressure at a relatively high level of -200 to 300 mmHg was used on the wound beds.…”