Analysis of Neonatal Respiratory Distress in Neonatal Intensive Care Unit at Nepal Medical College

Rijal, P; Shrestha, Mandira

doi:10.3126/jnhrc.v16i2.20297

Cited by 16 publications

(25 citation statements)

References 8 publications

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“…This finding is higher compared to other countries including Nepal (6.3%), Sudan (41%), Tanzania (20.8%), and Ghana (39.27%). 38 – 41 However, this finding is in line with reports from other studies. 7 , 42 , 43 .…”

Section: Discussionsupporting

confidence: 93%

Clinical outcome and associated factors of respiratory distress syndrome among preterm neonates admitted to the neonatal intensive care unit of Adama Hospital and Medical College

2022

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Objective: Aim of the study was to assess the clinical outcome and associated factors of respiratory distress syndrome among preterm neonates admitted to the neonatal intensive care unit of Adama Hospital and Medical College. Methods: Hospital-based cross-sectional study was conducted using 242 randomly selected medical records of preterm neonates admitted to Adama comprehensive specialized hospital. Clinical outcome was categorized as poor if the neonate died or left against advice and good if discharged after improvement. Data were coded, entered into Epidata v.7.4.2 and exported to SPSS v.27 for analysis. After initial bi-variable logistic regression analysis, predictor variables with p-value of <0.2 were included in multivariable analysis. Significant association of factors with clinical outcome was claimed at p-value <0.05 and calculated 95% adjusted odds ratio. Results: Majority of admissions were male (63.2%), mean birth weight of 1440.3 g (+321.2 SD) and sepsis (82%), hypothermia (73%), and apnea (21.5%) were leading comorbidities. One hundred fifty-two (62.8%) of preterm neonates had poor outcomes. Neonates born singleton were 47% less likely to develop poor clinical outcomes (adjusted odds ratio 0.53 (0.48–0.94). The odds of poor clinical outcomes were higher during the first 3 days of admission (adjusted odds ratio 3.83 (3.28–14.77). Extremely preterm neonates (adjusted odds ratio 4.16 (4.01–12.97), extremely low birth weight preterm neonates had higher odds of poor clinical outcome. Conclusion: The study found higher poor clinical outcome among preterm neonates admitted with respiratory distress syndrome. Poor outcome was higher in lower gestational age, lower birth weight, twins and majority of it happened during 3 days of their life. Effective preventive care and initiation of low-cost, life-saving interventions including heated humidified high-flow nasal cannula and surfactant administration could significantly improve the clinical outcome of the neonates.

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Section: Discussionsupporting

confidence: 93%

Clinical outcome and associated factors of respiratory distress syndrome among preterm neonates admitted to the neonatal intensive care unit of Adama Hospital and Medical College

2022

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“…In addition, the study conducted in Bulgaria was conducted among preterm neonate whose mother took dexamethasone. However, proportion was lower than the study conducted, in Cameroon 47.5% [ 3 ], 54,3% in Poland [ 15 ], 54.7% Saudi Arabia [ 44 ], 49.6% in Egypt [ 45 ]. The possible reasons could be the study conducted in Poland was conducted among preterm births from PROM mother which may increase the burden.…”

Section: Discussionmentioning

confidence: 80%

“…Being born preterm increases risk of dying because of immature organs [6,7]. Hyaline membrane disease (HMD) is the leading cause of mortality and morbidity in preterm newborn babies [8][9][10][11][12], 45% of cause of death in Ethiopia [13], 46.9% in Nigeria [14], 12.8% in Poland [15]. In addition, the burden of NRDS among neonates reported as 52.9% of total admission in Egypt [16], 26.2% in Nigeria [14], 34.7% in Iraq [17], 57% in north India [18], 23.5% in nepal [19],11.9% in Jimma [20].…”

Section: Introductionmentioning

confidence: 99%

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

et al. 2021

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Background Hyaline membrane disease (HMD) is a leading cause of morbidity and mortality in preterm newborn babies. Though, there are studies related to Hyaline membrane disease inclusive of all neonates, studies related to the burden among preterm neonates were limited. In addition, increasing neonatal mortality in Ethiopia could be related to increase in the burden of hyaline membrane disease among preterm neonates. Therefore, this study was aimed to assess the burden of hyaline membrane disease, mortality and its associated factors among preterm neonate admitted at neonatal intensive care unit, North Central Ethiopia. Methodology An institution-based retrospective follow-up study was conducted among 535 preterm neonates admitted at neonatal intensive care unit from January 1, 2014-December 30, 2017. Data were entered into EPi-data 4.2.0.0 and transferred to STATA version 14 statistical software for statistical analysis. Binary logistic regression was used for the analysis. All variables with P-value < 0.25 during bi-variable analysis were considered for multivariable logistic regression. Level of statistical significance was declared at P value ≤0.05. Results In the current study, proportion of hyaline membrane disease was 40% (95% CI; 35.8, 44.3) of which 49.5% died. Preterm neonate born with Gestational age of less than 34 weeks of age (Adjusted odd ratio (AOR = 2.64; 95 CI: 1.49, 4.66)), 5th minute Apgar score less than 7 (AOR = 2.2; 95% CI: 1.20, 4.07), and newborn with birth weight of less than 1500 gram (AOR = 2.4, 95% CI: 1.3, 4.3) were predictors of hyaline membrane disease. Conclusions The mean gestational age (±) was 33.46 (±2.55) weeks. The incidence of hyaline membrane disease among preterm admissions was high. Preterm neonate born with gestational age of less than 34 weeks of age, asphyxiated newborns and newborn with birth weight of less than 1500 gram were predictors of hyaline membrane disease. So, emphasis should be given on early screening, follow up and timely interventions for preterm neonate.

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“…Therefore, all the studies were considered [2,[6][7][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] (5)) up to 77.9 % (Getabelew et al (34)). From those studies, the pooled prevalence of neonatal sepsis in East Africa was 29.65 %( 95%CI; 23.…”

Section: Results Study Selectionmentioning

confidence: 99%

Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis, 2019

Beletew

Kassie

Kassaw

et al. 2019

Preprint

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Background: Neonatal sepsis is one of the most leading causes of inflated death and illness of neonates. Different primary studies in Eastern Africa showed the burden of neonatal sepsis. However, inconsistency among those studies was seen and no review has been conducted to report the amalgamated magnitude and associated factors. Therefore, this review aimed to estimate the national prevalence and associated factors of neonatal sepsis in Eastern Africa. Methods: Using PRISMA guideline, we systematically reviewed and meta-analyzed studies that examined the prevalence and associated factors of neonatal sepsis from PubMed, Cochrane library, and Google Scholar. Heterogeneity across the studies was evaluated using the Q and the I2 test. A weighted inverse variance random-effects model was applied to estimate the national prevalence and the effect size of associated factors. The subgroup analysis was conducted by country, study design, and year of publication. A funnel plot and Egger’s regression test were used to see publication bias. Result: A total of 26 studies with 11239 participants were used for analysis. The pooled prevalence of neonatal sepsis in East Africa was 29.65% (95% CI; 23.36–35.94).Home delivery(AOR =2.67; 95% CI: 1.15-4.00; I2= 0.0%; P=0.996), maternal history of UTI (AOR=2.083; 95% CI :0.24-3.93; I2= 69.1%; P=0.001),gestational age (preterm) (AOR=1.56; 95% CI: 1.04-2.08; I2= 27.8%;P=0.000) ,prolonged labor (AOR=3.23 ;95% CI: -0.04-6.51; I2= 62.7%; P=0.020) and PROM (AOR= 1.95; 95% CI: 0.53-3.37; I2= 43.2%; P=0.062) were identified factors of neonatal sepsis. Conclusions: The prevalence of neonatal sepsis in Eastern Africa remains high. This review may help policy-makers and program officers to design neonatal sepsis preventive interventions. Keywords: Neonatal sepsis, Eastern Africa

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Analysis of Neonatal Respiratory Distress in Neonatal Intensive Care Unit at Nepal Medical College

Cited by 16 publications

References 8 publications

Clinical outcome and associated factors of respiratory distress syndrome among preterm neonates admitted to the neonatal intensive care unit of Adama Hospital and Medical College

Clinical outcome and associated factors of respiratory distress syndrome among preterm neonates admitted to the neonatal intensive care unit of Adama Hospital and Medical College

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study

Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis, 2019

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