Analysis of monofluoroacetic acid in urine by liquid chromatography-triple quadrupole mass spectrometry and preparation of the positive sample by the bioconversion from monofluoroacetamide to monofluoroacetic acid in vitro

Xu, Xia; Cai, Zengxuan; Zhang, Jingshun; Ren, Yiping; Han, Jiaguang

doi:10.1016/j.jchromb.2016.05.026

Cited by 6 publications

(5 citation statements)

References 18 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from basic compounds, acids (Svahn & Björklund, ; X.‐M. Xu, Cai, Zhang, Ren, & Han, ), neutral compounds (Tan et al, ; Tan, Gu, et al, ; Hirabayashi, Sugimoto, Matsumoto, Amano, & Moriwaki, ; Rainville et al, ; Svahn & Björklund, ), and peptides (Oe et al, ) can all benefit from the use of high‐pH mobile phases. Sometimes a basic mobile phase is the only option.…”

Section: Benefits Of Using High‐ph Mobile Phasesmentioning

confidence: 99%

See 1 more Smart Citation

Use of high‐pH (basic/alkaline) mobile phases for LC–MS or LC–MS/MS bioanalysis

Tan

Fanaras

2018

Biomedical Chromatography

View full text Add to dashboard Cite

High-pH or basic/alkaline mobile phases are not commonly used in LC-MS or LC-MS/MS bioanalysis because of the deeply rooted concern with column instability and reduced detection sensitivity for basic compounds in high-pH mobile phases owing to charge neutralization. With the advancement of LC column technology and the wide recognition of the "wrong-way-round" phenomena, high-pH mobile phases are more and more used in LC-MS or LC-MS/MS bioanalysis to improve chromatographic peak shape, retention, selectivity, resolution, and detection sensitivity, not only for basic compounds, but also for many other compounds. In this article, the benefits, practical considerations, application examples and cautions for using high-pH mobile phases in LC-MS or LC-MS/MS bioanalysis are reviewed, with a focus on quantification. Furthermore, the future trends in this field are also envisaged.A total of 84 references are cited in this review. KEYWORDS alkaline mobile phase, basic mobile phase, bioanalysis, high pH, LC-MS, LC-MS/MS

show abstract

Section: Benefits Of Using High‐ph Mobile Phasesmentioning

confidence: 99%

“…For monofluoroacetic acid (a very polar compound), X.‐M. Xu, Cai, et al () used a basic mobile phase to achieve the highest sensitivity in ESI− ionization and satisfactory retention and chromatographic peak shape in HILIC separation with an XBridge BEH Amide column.…”

Section: Exemplary Applicationsmentioning

confidence: 99%

Use of high‐pH (basic/alkaline) mobile phases for LC–MS or LC–MS/MS bioanalysis

Tan

Fanaras

2018

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…4,5 Both sodium fluoroacetate and fluoroacetamide can be easily metabolized to fluoroacetic acid (FAcOH), which can block the tricarboxylic acid (Krebs) cycle, thereby producing a series of clinical symptoms such as seizures, arrhythmia, or even death. 3,6 FAcOH, as a highly toxic substance, is also found in many poisonous plants and can cause death to surrounding organisms. 7 Toxicity of FAcOH has been reported in literatures; the oral lethal doses of sodium fluoroacetate in human are about 2-5 mg/kg and are 0.06-0.20 mg/kg in dogs.…”

Section: Introductionmentioning

confidence: 99%

“…7 Toxicity of FAcOH has been reported in literatures; the oral lethal doses of sodium fluoroacetate in human are about 2-5 mg/kg and are 0.06-0.20 mg/kg in dogs. 6,8 A few studies on FAcOH are animals' experiments, such as sheep, cat, or rat. [9][10][11] FAcOH has been reported to produce hematological and biochemical changes in different animal species.…”

Section: Introductionmentioning

confidence: 99%

Plasma fluoroacetic acid concentrations: Symptoms, hematological, and biochemical characteristics in patients with fluoroacetic acid poisoning in the emergency department

Liu

Dong

et al. 2020

Hum Exp Toxicol

View full text Add to dashboard Cite

Fluoroacetic acid (FAcOH) was once a highly toxic rodenticide widely used in the world. In the past, studies on the toxicity of FAcOH have focused on animal experiments. The toxicity of FAcOH to humans and the changes of FAcOH in plasma have not been studied. Therefore, the present study aimed to describe the changes of plasma FAcOH concentrations, hematological, and biochemical characteristics in patients with FAcOH intoxication. According to clinical symptoms, 68 patients from the emergency department were divided into different groups: convulsion group, unconsciousness group, death group, and control groups. Plasma FAcOH concentrations, hematological, and biochemical parameters were investigated. Results demonstrated that patients in the convulsion group and the unconsciousness group had a significant increase ( p < 0.01) in the level of neuron-specific enolase (NSE), creatine kinase MB (CKMB), glucose (GLU), and white blood cell count (WBC) and a significant decrease ( p < 0.01) in serum potassium compared with the control group, respectively. Moreover, patients in the death group had a significant increase ( p < 0.01) in the level of NSE, CKMB, N-terminal pro-brain natriuretic peptide, GLU, and WBC and a significant decrease ( p < 0.01) in serum potassium and total calcium compared with the survival group. The concentrations of FAcOH in plasma in the convulsion group, the unconsciousness group, and the death group were 72.31 ± 42.29, 118.33 ± 55.41, and 163.78 ± 43.32 μg/mL, respectively. These changes and the plasma FAcOH concentrations may increase our understanding of the toxicity of FAcOH to humans and may help doctors to judge the clinical prognosis of patients with FAcOH intoxication.

show abstract

“…As a food defense measure, developing rapid, low-cost, and user-friendly detecting platforms for FAcOH in food and biological samples is critical to reduce the likelihood of agro-terrorism incidents. 3 Currently, forensic work traditionally employs laboratory-based complex instruments such as gas chromatography−mass spectrometry (GC-MS) 4 or liquid chromatography−mass spectrometry (LC-MS), 5 as well as capillary electrophosis (CE) 6 for FAcOH confirmation. However, these methods could not satisfy rapid on-field early identification for trace FAcOH related to food terrorist incidents.…”

mentioning

confidence: 99%

In Situ Growth Large Area Silver Nanostructure on Metal Phenolic Network Coated NAAO Film and Its SERS Sensing Application for Monofluoroacetic Acid

et al. 2021

View full text Add to dashboard Cite

Rapid screening monofluoroacetic acid (FAcOH) is responsible for preventing chemical poisoning and food safety events. Whereas surface enhanced Raman scattering (SERS) spectra is an effective tool for detecting forbidden chemicals, it is difficult to directly detect FAcOH due to its small Raman scattering cross section as well as weak adsorption on SERS substrates. In this work, the metal phenolic supramolecular networks (MPNs, i.e., the tannic acid and Fe 3+ complex) were fabricated on the commercial nanoanodic aluminum oxide film (NAAO) for assisting in situ chemical deposition highly uniform Ag nanostructure over large areas (the NAAO@AgNS). The low cost and simple fabrication process made the NAAO@AgNS a single-use consumable. For FAcOH detection, a specific derivative reaction between FAcOH and thiosalicylic acid (TSA) was introduced. By taking TSA as the Raman probe, its SERS signal attenuated constantly with the increasing amount of FAcOH. For improving quantitative accuracy, thiocyanate (SCN − ) was introduced on the NAAO@AgNS as an internal standard; thus, the characteristic peak intensity ratios associated with TSA and SCN − (I 1035 /I 2125 ) were fitted to the concentration of FAcOH. It was demonstrated that the SERS assay achieved good sensitivity and selection toward FAcOH with the limit of quantitation (LOD) as low as 50 nmol L −1 . The NAAO@AgNS featured with highly sensitive, uniform, and consistent SERS performances could easily extend to wide SERS applications.

show abstract

Analysis of monofluoroacetic acid in urine by liquid chromatography-triple quadrupole mass spectrometry and preparation of the positive sample by the bioconversion from monofluoroacetamide to monofluoroacetic acid in vitro

Cited by 6 publications

References 18 publications

Use of high‐pH (basic/alkaline) mobile phases for LC–MS or LC–MS/MS bioanalysis

Use of high‐pH (basic/alkaline) mobile phases for LC–MS or LC–MS/MS bioanalysis

Plasma fluoroacetic acid concentrations: Symptoms, hematological, and biochemical characteristics in patients with fluoroacetic acid poisoning in the emergency department

In Situ Growth Large Area Silver Nanostructure on Metal Phenolic Network Coated NAAO Film and Its SERS Sensing Application for Monofluoroacetic Acid

Contact Info

Product

Resources

About