Abstract:The minimally invasive approach is a viable alternative with the possibility to reduce complications and should be particularly considered for bridge-to-transplant patients.
“…In recent years, LIS-LVAD implantation has been introduced for patients undergoing LVAD implantation, and this approach would gradually become the standard for patients who have no other concomitant heart diseases necessitating full median sternotomy. [19][20][21][22] The minimal invasiveness of the LIS-LVAD implantation procedure might yield better clinical outcomes, for example, lower transfusion rate, shorter cardiopulmonary bypass time, and lower perioperative mortality. 19,23 Recent research works presented the positive outcomes for avoiding right ventricular dilatation in LIS-LVAD implantation.…”
Background: Frailty influences the postoperative outcomes in patients undergoing left ventricular assist device (LVAD) implantation. Recently, erector spinae muscle (ESM) mass has been proposed as a parameter to assess frailty accurately. Thus, the purpose of the present study was to evaluate whether preoperative ESM mass is associated with short-and long-term clinical outcomes in patients with LVAD.Methods: A total of 119 consecutive patients with LVAD were enrolled between January 2010 and October 2017 at a single heart center. The ESM area, ESM index, and Hounsfield units (HU) of the ESM were calculated by computed tomography for preoperative ESM mass evaluation. We then statistically evaluated the in-hospital mortality, major adverse cardiovascular events (MACE), duration of hospital stay, and long-term survival.Results: In a multivariate Cox regression analysis, ESM mass indicated no effect on all clinical outcomes. In addition, the ESM area presented a weak but significant negative linear correlation only with the duration of hospital stay (r = −0.21, p < .05).In contrast, the Model For End-stage Liver Disease (MELD) score and preoperative venous-arterial extracorporeal membrane oxygenation (va-ECMO) were significant predictive factors for in-hospital mortality (MELD score: p < .001, hazard ratio [HR]
“…In recent years, LIS-LVAD implantation has been introduced for patients undergoing LVAD implantation, and this approach would gradually become the standard for patients who have no other concomitant heart diseases necessitating full median sternotomy. [19][20][21][22] The minimal invasiveness of the LIS-LVAD implantation procedure might yield better clinical outcomes, for example, lower transfusion rate, shorter cardiopulmonary bypass time, and lower perioperative mortality. 19,23 Recent research works presented the positive outcomes for avoiding right ventricular dilatation in LIS-LVAD implantation.…”
Background: Frailty influences the postoperative outcomes in patients undergoing left ventricular assist device (LVAD) implantation. Recently, erector spinae muscle (ESM) mass has been proposed as a parameter to assess frailty accurately. Thus, the purpose of the present study was to evaluate whether preoperative ESM mass is associated with short-and long-term clinical outcomes in patients with LVAD.Methods: A total of 119 consecutive patients with LVAD were enrolled between January 2010 and October 2017 at a single heart center. The ESM area, ESM index, and Hounsfield units (HU) of the ESM were calculated by computed tomography for preoperative ESM mass evaluation. We then statistically evaluated the in-hospital mortality, major adverse cardiovascular events (MACE), duration of hospital stay, and long-term survival.Results: In a multivariate Cox regression analysis, ESM mass indicated no effect on all clinical outcomes. In addition, the ESM area presented a weak but significant negative linear correlation only with the duration of hospital stay (r = −0.21, p < .05).In contrast, the Model For End-stage Liver Disease (MELD) score and preoperative venous-arterial extracorporeal membrane oxygenation (va-ECMO) were significant predictive factors for in-hospital mortality (MELD score: p < .001, hazard ratio [HR]
“…Initial limited single-center analyses corroborated noninferiority of the less invasive pump implantation (1,2). Consequently, encouraging clinical outcomes were demonstrated in the multicenter, prospective, nonrandomized LATERAL trial with 144 patients using the HeartWare Ventricular Assist System (HVAD) (Medtronic, Minneapolis, MN, USA) significantly outperforming the historical sternotomy access performance goal (3).…”
Section: Clinical Resultsmentioning
confidence: 98%
“…A protective effect on right ventricular function by maintaining a physiological pericardial restraint is broadly discussed. Nonetheless, a need for temporary RV support has been reported for the aforementioned surgical strategy (2). Ultimately, the authors consider the most prominent advantage in previous sternotomy implants by mitigating adhesion-related injury and bleeding to heart structures (5).…”
“…Thirteen retrospective cohort studies published between 2014 and 2020 met the eligibility criteria and were included in the analysis (Table 1 [18][19][20][21][22][23][24][25][26][27][28][29][30] ). A PRISMA flow diagram of the literature search is provided as Figure 1.…”
Background and aim: Thoracotomy approaches to left ventricular assist device (LVAD) implantation may reduce surgical morbidity and, through preservation of the pericardial restraint over the right heart, may reduce the incidence of right ventricular failure (RVF).Methods: A meta-analysis of all original studies describing the effect of the surgical approach on postoperative outcomes after LVAD implantation was performed.
Postoperative outcomes analyzed.Results: Thirteen studies were included with 692 patients undergoing a sternotomy and 373 a thoracotomy approach. Patients undergoing a thoracotomy approach had a higher comorbid status (INTERMACS 1-2: 56% vs. 44%; p = .0004), but were less likely to undergo a concomitant procedure (4% vs. 15%; p = .0002) than patients undergoing a sternotomy approach. Patients undergoing a thoracotomy approach demonstrated a
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