Analysis of Microvasculature in Children Recovered from COVID-19 Using Swept-Source OCT/OCTA Technology

Çetinkaya, Tuğba; Kurt, Muhammed; Cetinkaya, Harun; Akpolat, Çetin

doi:10.1080/09273948.2022.2054431

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Several reports have shown a reduction in vessel density among patients who recovered from COVID-19. These studies noted a decrease in the superficial capillary plexus (SCP) 15 – 19 , 21 – 24 , 26 and deep capillary plexus (DCP) 16 , 17 , 21 – 23 , 26 . Although these results are interesting, certain confounding variables were not accounted for.…”

Section: Discussionmentioning

confidence: 98%

Retinal tissue and microvasculature loss in COVID-19 infection

Kalaw

Warter

Cavichini

et al. 2023

Sci Rep

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This cross-sectional study aimed to investigate the hypothesis that permanent capillary damage may underlie the long-term COVID-19 sequela by quantifying the retinal vessel integrity. Participants were divided into three subgroups; Normal controls who had not been affected by COVID-19, mild COVID-19 cases who received out-patient care, and severe COVID-19 cases requiring intensive care unit (ICU) admission and respiratory support. Patients with systemic conditions that may affect the retinal vasculature before the diagnosis of COVID-19 infection were excluded. Participants underwent comprehensive ophthalmologic examination and retinal imaging obtained from Spectral-Domain Optical Coherence Tomography (SD-OCT), and vessel density using OCT Angiography. Sixty-one eyes from 31 individuals were studied. Retinal volume was significantly decreased in the outer 3 mm of the macula in the severe COVID-19 group (p = 0.02). Total retinal vessel density was significantly lower in the severe COVID-19 group compared to the normal and mild COVID-19 groups (p = 0.004 and 0.0057, respectively). The intermediate and deep capillary plexuses in the severe COVID-19 group were significantly lower compared to other groups (p < 0.05). Retinal tissue and microvascular loss may be a biomarker of COVID-19 severity. Further monitoring of the retina in COVID-19-recovered patients may help further understand the COVID-19 sequela.

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Section: Discussionmentioning

confidence: 98%

Retinal tissue and microvasculature loss in COVID-19 infection

Kalaw

Warter

Cavichini

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…OCTA, a non-invasive imaging modality, can show images of blood flow in all the vascular layers of the the retina [31] . Vascular structures around the macula and optic disc in pediatric patients recovering from COVID-19 were evaluated with OCTA and compared with healthy children[ [5] , [6] , [7] , 10 ]. Guemes-Villahoz et al [5] .…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies of eye involvement in pediatric patients with COVID-19 have included limited numbers of patients and have focused primarily on pathologies occurring in the anterior segment of the eye. To the best of our knowledge, there are few studies investigating posterior segment involvement in this age group [5] , [6] , [7] , [8] , [9] , [10] .…”

Section: Introductionmentioning

confidence: 99%