Analysis of medicinally important phytocompounds from Argemone mexicana

Khan, Aziz Mohammad; Bhadauria, Seema

doi:10.1016/j.jksus.2018.05.009

Cited by 20 publications

(8 citation statements)

References 16 publications

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“…Secondary metabolites such as alkaloids, favonoids, tannins, steroids, glycosides, and terpenoids were found in the EAF after the phytochemical screening. Tis result is in line with other reports which used a series of solvents to conduct phytochemical analyses of the various plant parts of A. mexicana [102,103]. Te anti-infammatory properties are attributed to the presence of such types of secondary metabolites.…”

Section: Discussionsupporting

confidence: 91%

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Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

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Section: Discussionsupporting

confidence: 91%

“…This result is in line with other reports which used a series of solvents to conduct phytochemical analyses of the various plant parts of A . mexicana [ 102 , 103 ]. The anti-inflammatory properties are attributed to the presence of such types of secondary metabolites.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Due to its strong medicinal potential, A . mexicana has been analyzed by several research groups to determine its main secondary metabolites, which include phenolics (such as flavonoids and tannins), terpenoids (such as glycosides) and N-containing compounds (such as alkaloids), as well as saponins and steroids [ 30 , 31 ]. Although some studies have been conducted to better understand these compounds and the biological activities of A .…”

Section: Introductionmentioning

confidence: 99%

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

et al. 2021

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Commonly called the Mexican prickly poppy, Argemone mexicana is a stress-resistant member of the Papaveraceae family of plants that has been used in traditional medicine for centuries by indigenous communities in Mexico and Western parts of the United States. This plant has been exploited to treat a wide variety of ailments, with reported antimicrobial and antioxidant properties, as well as cytotoxic effects against some human cancer cell lines. Due to its various therapeutic uses and its abundance of secondary metabolites, A. mexicana has great potential as a drug discovery candidate. Herein, the germination conditions of A. mexicana are described and the cytotoxic activities of different parts (seeds, leaves, inner vs. outer roots) of the plant from methanol or hexane extracts are preliminarily characterized against cells of seven unique organisms. When comparing 1 mg of each sample normalized to background solvent alone, A. mexicana methanol outer root and leaf extracts possessed the strongest antimicrobial activity, with greatest effects against the Gram-positive bacteria tested, and less activity against the Gram-negative bacteria and fungi tested. Additionally, using the MTT colorimetric assay, the outer root methanol and seed hexane extracts displayed pronounced inhibitory effects against human colon cancer cells. Quantification of c-MYC (oncogene) and APC (tumor suppressor) mRNA levels help elucidate how the A. mexicana root methanol extract may be affecting colon cancer cells. After ultra-performance liquid chromatography coupled with mass spectrometry and subsequent nuclear magnetic resonance analysis of the root and leaf methanol fractions, two main antibacterial compounds, chelerythrine and berberine, have been identified. The roots were found to possess both phytocompounds, while the leaf lacked chelerythrine. These data highlight the importance of plants as an invaluable pharmaceutical resource at a time when antimicrobial and anticancer drug discovery has plateaued.

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“…The emergence of drug-resistant microbial strains [28] has necessitated the search for antimicrobial compounds from natural sources, such as plants and marine microorganisms. Many studies have determined the antimicrobial effects and secondary metabolites of A. mexicana [29,30]. Recently, A study by Orozco-Nunnelly et al, 2021 [28] has shown that the methanolic extract of outer roots and leaves displayed strong antimicrobial activities, especially against Gram-positive bacteria.…”

Section: Antimicrobial Activity Of Various a Mexicana Extractsmentioning

confidence: 99%

Analysis of Biochemical and Antimicrobial Properties of Bioactive Molecules of Argemone mexicana

et al. 2023

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This study identified phytochemicals in Argemone mexicana (A. mexicana) extracts that are responsible for its medicinal properties, and the best solvent for their extraction. The extracts of the stem, leaves, flowers, and fruits of A. mexicana were prepared at low (corresponding to room temperature) and high temperatures (corresponding to the boiling points) in various solvents, viz., hexane, ethyl acetate, methanol, and H2O. The UV-visible absorption spectra of various phytoconstituents in the isolated extracts were determined through spectrophotometry. Qualitative tests for the screening of phytoconstituents in the extracts were performed to identify various phytochemicals. We identified the presence of terpenoids, alkaloids, cardiac glycosides, and carbohydrates in the plant extracts. The antioxidant and anti-human immunodeficiency virus type 1 reverse transcriptase (anti-HIV-1RT) potential, as well as the antibacterial activity of various A. mexicana extracts were determined. These extracts showed strong antioxidant activities. The extracts exhibited antimicrobial activities against Salmonella typhi, Staphylococcus epidermis, Citrobacter, Neisseria gonorrhoeae, and Shigella flexineri. These extracts significantly inhibited HIV-1 reverse transcriptase activity. The aqueous leaf extract prepared at a temperature equivalent to the boiling point, i.e., 100 °C, was identified to be the most active against pathogenic bacteria and HIV-1 RT.

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Analysis of medicinally important phytocompounds from Argemone mexicana

Cited by 20 publications

References 16 publications

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

Analysis of Biochemical and Antimicrobial Properties of Bioactive Molecules of Argemone mexicana

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