Analysis of maternal and child health spillover effects in PEPFAR countries

Abstract

ObjectivesThis study examined whether the US President’s Emergency Plan for AIDS Relief (PEPFAR) funding had effects beyond HIV, specifically on several measures of maternal and child health in low-income and middle-income countries (LMICs). The results of previous research on the question of PEPFAR health spillovers have been inconsistent. This study, using a large, multicountry panel data set of 157 LMICs including 90 recipient countries, adds to the literature.DesignSeven indicators including child and maternal mortality, several child vaccination rates and anaemia among childbearing-age women are important population health indicators. Panel data and difference-in-differences estimators (DID) were used to estimate the impact of the PEPFAR programme from inception in 2004 to 2018 using a comparison group of 67 LMICs. Several different models of baseline (2004) covariates were used to help balance the comparison and treatment groups. Staggered DID was used to estimate impacts since all countries did not start receiving aid at PEPFAR’s inception.SettingAll 157 LMICs from 1990 to 2018.Participants90 LMICs receiving PEPFAR aid and cohorts of those countries, including those required to submit annual country operational plans (COP), other recipient countries (non-COP), and three groupings of countries based on cumulative amount of per capita aid received (high, medium, low).InterventionsPEPFAR aid to combat the HIV epidemic.Primary outcome measuresMaternal mortality and child mortality rates, vaccination rates to protect children for diphtheria, whooping cough and tetanus, measles, HepB3, and tetanus, and prevalence of anaemia in women of childbearing age.ResultsAcross PEPFAR recipient countries, large, favourable PEPFAR health effects were found for rates of childhood immunisation, child mortality and maternal mortality. These beneficial health effects were large and significant in all segments of PEPFAR recipient countries studied. We also found significant and favourable programme effects on the prevalence of anaemia in women of childbearing age in PEPFAR recipient countries receiving the most intensive financial support from the PEPFAR programme. Other recipient countries did not demonstrate significant effects on anaemia.ConclusionsThis study demonstrated that important health indicators, beyond HIV, have been consistently and favourably influenced by PEPFAR presence. Child and maternal mortality have been substantially reduced, and childhood immunisation rates increased. We also found no evidence of ‘crowding out’ or negative spillovers in these resource-poor countries. These findings add to the body of evidence that PEPFAR has had favourable health effects beyond HIV. The implications of these findings are that foreign aid for health in one area may have favourable health effects in other areas in recipient countries. More research is needed on the influence of the mechanisms at work that create these spillover health effects of PEPFAR.

A Hybrid Simulation Model of HIV Program Interventions: From Transmission Behavior to Macroeconomic Impacts

“…One example is our set of recent analyses done to assess the association between PEPFAR, the U.S. government’s global HIV program and largest commitment by any country addressing a single disease (Bor J et al, 2012; Guo Y et al, 2012; Resch S et al, 2011; Thirumurthy H et al, 2012) and several health and non-health-outcomes. We found that PEPFAR investments were associated with large, significant reductions in all-cause mortality (Gaumer G et al, 2024), reductions in maternal and child mortality and increases in childhood immunizations (Gaumer et al, 2023), as well as significant, positive, impacts on educational levels and gross domestic product (GDP) (Crown W et al, 2023). However, despite these impacts on mortality, educational levels, and GDP we did not find positive impacts on employment.…”