Analysis of magnetic resonance imaging (MRI) morphometry and cerebral blood flow in patients with hypoxic-ischemic encephalopathy

Anoxic Injury-Associated Cerebral Hyperperfusion Identified with Arterial Spin-Labeled MR Imaging

“…Different methodologies, different time periods, (initial 48 hours, initial week, and from 8 to 20 days), technical factors, exclusion of nonsurvivors in 2 studies, small sample size of nonsurvivors (n ϭ 6, Cohan et al 4 ), and persistent vegetative state (n ϭ 2, Inoue et al 5 , and n ϭ 8, Nogami et al 6 ) make it difficult to draw conclusions regarding the discrepancies between the xenon perfusion studies and the ASL data. Comparing the quantitative perfusion values between xenon and ASL is inconclusive, because 2 of the xenonbased studies used hemispheric perfusion values, whereas our ASL data were limited to GM perfusion.…”

“…Xenon CT perfusion has been used to evaluate postresuscitation patients with mixed results. [4][5][6] Other cerebral perfusion methods, such as nuclear medicine hexamethylpropyleneamine oxime singlephoton emission CT and O-15 positron-emission tomography (PET), rely on differences in regional perfusion and may not detect a global symmetric hyperperfusion pattern. 7 The goal of this study was to use ASL to characterize the perfusion patterns encountered after anoxic injury to the brain.…”

Benefits of the angiotensin II receptor antagonist olmesartan in controlling hypertension and cerebral hemodynamics after stroke

“…CBF and CRC were measured by Xe-CT 15,16,18 during the screening period, and after 8 weeks' treatment. CBF was measured using the stable Xe-CT technique described by Gur et al 16 The patients lay still on the scanner bed, in a quiet, dimly lit room, with their eyes covered and inhaled 30% Xe gas, which is stable, radio-dense, lipid-soluble, and rapidly and freely diffuses across the bloodbrain barrier, for 4 min.…”

“…4 Regions of interest (ROI) were defined with reference to Kretschmann and Weinrich's atlas. 21 CRC, defined as the change in CBF 20 min after ACZ injection, 18 was measured by taking two CBF measurements, at rest and 20 min after the intravenous administration of 1 g ACZ. 22 We also calculated the CBF response to ACZ, that is (CBFaczÀCBFrest/CBFrestÂ100%) as the 'CRC (%)' .…”

Capacities for the drug correction of functional disorders in posthypoxic encephalopathy

“…От длительности и степени выраженности гипоксии во многом зависят вероятность развития посткритических осложнений и исход заболева-ния. Принято считать, что аноксия длительностью 4-5 мин приводит к необратимым изменениям в головном мозге [4].…”