Capacities for the drug correction of functional disorders in posthypoxic encephalopathy

Odinak, M M; Emelin, A Yu; Lobzin, V Yu; Vorobyev, S V

doi:10.14412/2074-2711-2012-390

Cited by 2 publications

(1 citation statement)

References 9 publications

(10 reference statements)

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“…In a number of cases, the establishment of such connections requires taking into account a variety of factors-complexes that appear in the course of the interrelated processes of damage and adaptation in response to the injury and inevitably arise during the provision of medical care for the correction of premortal pathology, the elimination of its main cause. The main significance in this group of circumstances is given to cerebral hypoxia, which can be observed in a variety of pathological conditions: Shock, poisoning with various gases, drugs, myasthenia, persistent status epilepticus, mechanical asphyxia, various acute disorders of the circulatory system, and respiratory regulation disorders [16] . Gray matter structures are most vulnerable to hypoxic damage due to their need for oxygen and glucose to supply a large number of synapses [10] .…”

Section: Introductionmentioning

confidence: 99%

Mental disorder as an example of sequelae of cerebral hypoxia-ischemia in case of acute blood loss in forensic medicine

Yurievna,

Grand

2024

Int. J. Forensic Med.

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Defining the full range of injuries and their causes is one of the most important issues in forensic medicine. Particularly difficult and insufficiently developed is the assessment of injuries manifested in a mental disorder. Forensic diagnostics in this case requires knowledge of the mechanism of injury, the peculiarities of the formation of injuries, and their correlation with neuropathological disorders. Presented is the case in which a complex of processes in response to the primary injury and pathological processes attached to the injury led to structural and functional insufficiency of the brain (encephalopathy), the manifestation of which was an organic mental disorder. Its analysis contributes to the understanding of the process of decoding the information contained in the objects of expertise, assessing the elements of the cause-and-effect relationship and making scientifically based expert conclusions.

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Section: Introductionmentioning

confidence: 99%

Mental disorder as an example of sequelae of cerebral hypoxia-ischemia in case of acute blood loss in forensic medicine

Yurievna,

Grand

2024

Int. J. Forensic Med.

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Posthypoxic encephalopathy in patients after cardiac surgery: etiological, pathogenetic, and clinical aspects (a literature review)

Алексеева

Portik

Топузова

2018

Nevrologiâ, nejropsihiatriâ, psihosomatika

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Post-hypoxic encephalopathy is a brain damage manifested by neurological, neuropsychiatric, and mental disorders, which is caused by a reduction in cerebral blood flow and by a resultant effect of an episode of hypoxia of various etiology and duration. This complication is most characteristic of patients who have undergone cardiac surgery in view of the high prevalence and severity of clinical manifestations, worse quality of life, the longer length of hospital stay, and the higher cost of treatment and rehabilitation. To determine the individual management tactics for such patients, combining both successful surgical treatment, by reducing perioperative stress, and prevention of cerebral complications, it is necessary to analyze the patterns of their development. The role of pathophysiological risk factors, including preoperative, perioperative and postoperative ones, for posthypoxic encephalopathy, is considered. Its preoperative risk factors include age, gender, concomitant diseases, education level, and cognitive functions before surgery, cardiac morphofunctional changes, and depressive disorders. There are surgery-related (type and duration of anesthesia, operating-suite temperatures, and hyperglycemia) and postoperative (pain syndrome after surgical intervention, sleep disorders, and the environment) risk factors. Emphasis is placed on the technical characteristics of on-pump operations, among which there are cerebral hypoperfusion, microembolism, non-pulsatile flow, and duration of extracorporeal circulation. Classifications of cerebral complications are presented. Different types of brain dysfunction are analyzed to assess their incidence rates, clinical features, and dynamics in the postoperative period.

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Capacities for the drug correction of functional disorders in posthypoxic encephalopathy

Cited by 2 publications

References 9 publications

Mental disorder as an example of sequelae of cerebral hypoxia-ischemia in case of acute blood loss in forensic medicine

Mental disorder as an example of sequelae of cerebral hypoxia-ischemia in case of acute blood loss in forensic medicine

Posthypoxic encephalopathy in patients after cardiac surgery: etiological, pathogenetic, and clinical aspects (a literature review)

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