Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry

Sacher, Frank; Raue, Brigitte; Brauch, Heinz‐Jürgen

doi:10.1016/j.chroma.2005.01.031

Cited by 38 publications

(18 citation statements)

References 15 publications

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“…Then, two other popular X-ray contrast media agents (IOX and IOP) were studied as I.S. The extraction recovery of these chemicals was IOP > IOM > IOX > IOD, which was coincident with the previous literatures [32,33]. According to the literatures, the polarity of these chemicals is IOD > IOX > IOM > IOP.…”

Section: Choice Of the Internal Standardmentioning

confidence: 85%

Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

Zhou

Tao

et al. 2015

Journal of Chromatography B

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Section: Choice Of the Internal Standardmentioning

confidence: 85%

Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

Zhou

Tao

et al. 2015

Journal of Chromatography B

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“…Also, Brauch et al developed a method for analyzing environmental samples containing iodine-based X-ray contrast agents. They used IC directly coupled to ICP-MS detection to analyze water samples [134]; limits of detection in the upper ppt (ng kg −1 ) range were achieved.…”

Section: Iodinementioning

confidence: 99%

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

Meermann

Sperling

2012

Anal Bioanal Chem

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Method development and applications of hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals are summarized within this review. Advantages and limitations of the separation modes-high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography (GC)-as well as the detection modes-inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization-mass spectrometry (ESI-MS)-are discussed. ICP-MS detection is found to be advantageous for the quantification of drugs containing metals and other heteroatoms. The species-independent sensitivity and multielement capabilities of ICP-MS allow it to be used for quantification even when species-specific standards are not available, as well as to determine the stoichiometry in metallodrug-biomolecule interactions. Molecular information that is totally destroyed when ICP is applied as ionization source and is therefore not obtainable via ICP-MS detection can be accessed by the complementary technique of ESI-MS. Speciation analysis combining both elemental and molecular information is therefore a powerful tool for the analysis of metal-based pharmaceuticals and their metabolites in body fluids and other relevant matrices.

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“…Eluiert wird mit einem NaOH-Gradienten. Bei dem sehr großen Probeninjektionsvolumen von 1 ml resultieren Nachweisgrenzen von 0,07-0,13 µg L -1 (Sacher et al 2005).…”

Section: Diverse Xenobioticaunclassified

Umweltanalytik mit Ionenchromatografie: Status quo und Zukunftsperspektiven

Fischer¹

2010

Environ Sci Eur

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Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry

Cited by 38 publications

References 15 publications

Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

Umweltanalytik mit Ionenchromatografie: Status quo und Zukunftsperspektiven

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