Analysis of integrated silicon nitride lab-on-a-chip optofluidic sensor at visible wavelength for absorbance based biosensing applications

Kumar, Manoranjan; Muniswamy, Venkatesha; Guha, Koushik; Iannacci, Jacopo; Krishnaswamy, Narayan

doi:10.1007/s00542-020-05193-x

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…These WGs can be used for various sensing applications, including biochemical sensing, environmental monitoring, and gas sensing. The evanescent field of light propagates through the WG interacts with the surrounding environment, allowing sensitive detection of changes in refractive indices or molecular interactions [34].…”

Section: Silicon Nitride (Si 3 N 4 )mentioning

confidence: 99%

Integrated Optics: Platforms and Fabrication Methods

Butt

2023

Encyclopedia

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Integrated optics is a field of study and technology that focuses on the design, fabrication, and application of optical devices and systems using integrated circuit technology. It involves the integration of various optical components, such as waveguides, couplers, modulators, detectors, and lasers, into a single substrate. One of the key advantages of integrated optics is its compatibility with electronic integrated circuits. This compatibility enables seamless integration of optical and electronic functionalities onto the same chip, allowing efficient data transfer between optical and electronic domains. This synergy is crucial for applications such as optical interconnects in high-speed communication systems, optical sensing interfaces, and optoelectronic integrated circuits. This entry presents a brief study on some of the widely used and commercially available optical platforms and fabrication methods that can be used to create photonic integrated circuits.

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Section: Silicon Nitride (Si 3 N 4 )mentioning

confidence: 99%

Integrated Optics: Platforms and Fabrication Methods

Butt

2023

Encyclopedia

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“…Several are the optical bio/sensor configurations that have been realized through optical fibers or planar waveguides. Optical sensors integrated on silicon-based substrates find uses in gas sensing (Siebert and Müller, 2005;Airoudj et al, 2008;Huang et al, 2014;Consani et al, 2018;Maurya et al, 2018), magnetic field sensing (Deghdak et al, 2017;Ge et al, 2021), detection of biological, and chemical species (Densmore et al, 2007;Mukundan et al, 2009;Schmitt et al, 2011;Kozma et al, 2014;Kumar et al, 2021). Moreover, these sensors offer all the advantages of the technological and fabrication processes typical of the microelectronic industry, such as the integration with other components, the low-cost, and the small-size of the produced device.…”

Section: Introductionmentioning

confidence: 99%

On the Effect of Soft Molecularly Imprinted Nanoparticles Receptors Combined to Nanoplasmonic Probes for Biomedical Applications

Cennamo

Bossi

Arcadio

et al. 2021

Front. Bioeng. Biotechnol.

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Soft, deformable, molecularly imprinted nanoparticles (nanoMIPs) were combined to nano-plasmonic sensor chips realized on poly (methyl methacrylate) (PMMA) substrates to develop highly sensitive bio/chemical sensors. NanoMIPs (dmean < 50 nm), which are tailor-made nanoreceptors prepared by a template assisted synthesis, were made selective to bind Bovine Serum Albumin (BSA), and were herein used to functionalize gold optical nanostructures placed on a PMMA substrate, this latter acting as a slab waveguide. We compared nanoMIP-functionalized non-optimized gold nanogratings based on periodic nano-stripes to optimized nanogratings with a deposited ultra-thin MIP layer (<100 nm). The sensors performances were tested by the detection of BSA using the same setup, in which both chips were considered as slab waveguides, with the periodic nano-stripes allocated in a longitudinal orientation with respect to the direction of the input light. Result demonstrated the nanoMIP-non optimized nanogratings showed superior performance with respect to the ultra-thin MIP-optimized nanogratings. The peculiar deformable character of the nano-MIPs enabled to significantly enhance the limit of detection (LOD) of the plasmonic bio/sensor, allowing the detection of the low femtomolar concentration of analyte (LOD ∼ 3 fM), thus outpassing of four orders of magnitude the sensitivies achieved so far on optimized nano-patterned plasmonic platforms functionalized with ultra-thin MIP layers. Thus, deformable nanoMIPs onto non-optimized plasmonic probes permit to attain ultralow detections, down to the quasi-single molecule. As a general consideration, the combination of more plasmonic transducers to different kinds of MIP receptors is discussed as a mean to attain the detection range for the selected application field.

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“…In the scientific literature, several configurations exist, based on planar slab waveguide integrated on silicon (Si)-based substrate used for multiple applications, like gas sensing [ 18 , 19 , 20 , 21 , 22 ], magnetic field sensing [ 23 , 24 ], biological and chemical species detection [ 2 , 6 , 25 , 26 , 27 ], and so on. These platforms take advantage of the technological and fabrication processes of the microelectronic industry.…”

Section: Introductionmentioning

confidence: 99%

A Nanoplasmonic-Based Biosensing Approach for Wide-Range and Highly Sensitive Detection of Chemicals

et al. 2021

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In a specific biosensing application, a nanoplasmonic sensor chip has been tested by an experimental setup based on an aluminum holder and two plastic optical fibers used to illuminate and collect the transmitted light. The studied plasmonic probe is based on gold nanograting, realized on the top of a Poly(methyl methacrylate) (PMMA) chip. The PMMA substrate could be considered as a transparent substrate and, in such a way, it has been already used in previous work. Alternatively, here it is regarded as a slab waveguide. In particular, we have deposited upon the slab surface, covered with a nanograting, a synthetic receptor specific for bovine serum albumin (BSA), to test the proposed biosensing approach. Exploiting this different experimental configuration, we have determined how the orientation of the nanostripes forming the grating pattern, with respect to the direction of the input light (longitudinal or orthogonal), influences the biosensing performances. For example, the best limit of detection (LOD) in the BSA detection that has been obtained is equal to 23 pM. Specifically, the longitudinal configuration is characterized by two observable plasmonic phenomena, each sensitive to a different BSA concentration range, ranging from pM to µM. This aspect plays a key role in several biochemical sensing applications, where a wide working range is required.

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Analysis of integrated silicon nitride lab-on-a-chip optofluidic sensor at visible wavelength for absorbance based biosensing applications

Cited by 5 publications

References 25 publications

Integrated Optics: Platforms and Fabrication Methods

Integrated Optics: Platforms and Fabrication Methods

On the Effect of Soft Molecularly Imprinted Nanoparticles Receptors Combined to Nanoplasmonic Probes for Biomedical Applications

A Nanoplasmonic-Based Biosensing Approach for Wide-Range and Highly Sensitive Detection of Chemicals

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