Analysis of Immunoexpression of Estrogen Receptor Beta and Extracellular Matrix Metalloproteinase Inducer (Emmprin) on Testicular Seminomas Nonrecurrence and Recurrence

Ridwan, Antonius Janes; Suryanti, Sri; Hassan, Abdul Hadi; Hernowo, Bethy S.

doi:10.28932/jmh.v1i2.507

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“…Observation of ERs α in the ovaries can be observed in theca cells and granulosa cells. The calculation of ERs α was carried out at 400x magnification with 5 fields of view per slide then analyzed with the help of Immunoratio software (Ridwan et al, 2015).…”

Section: Observation Of Ovarian Alpha Receptor Estrogen (Ers α) Expressionmentioning

confidence: 99%

Expression of estrogen receptors alpha (ERs α) and folliculogenesis profile in ovary of the rats ovarian hypofunction model

Firmawati

Hutabarat

Pratiwi

et al. 2021

JIIP

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Ovarian hypofunction is one of the reproductive disorders that occur due to a decrease in ovarian function that causes animals to not experience heat. The purpose of this study was to determine the effect of GnRH antagonist hormone interventions on ovarian hypofunction model rats by looking at the expression of alpha ERs (ERs α) and the profile of folliculogenesis in the ovaries. This study used two groups of female Wistar strain rats, aged 8-10 weeks, bodyweight 150-180 grams and each group contained 10 animals. Intervention gave control group, without cetrorelix acetate intervention (placebo aqua dest sterile), treatment group with the induction of cetrorelix acetate 0.0135 mg/kg BW for 17 days. Observation of α ERs expression in the ovary was analyzed by immunohistochemical methods, and data were analyzed using T-Test analysis (α <0.05). Meanwhile, the folliculogenesis profile was analyzed by hematoxylin-eosin (HE) staining, then analyzed descriptively. The results of this study indicate that the treatment group given the intervention cetrorelix acetate dose 0.0135 mg/kg BW showed significantly different results compared to the control group. In the treatment group, the ERs α expression decreased by 82.7% compared to the control group and in the folliculogenesis profile, there was a decrease in follicular development from pre-antral follicles to antral follicles. Cetrorelix acetate interventions can have an effect on the inhibition of folliculogenesis and estrogen binding with ERs that cause anoestrous.

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Section: Observation Of Ovarian Alpha Receptor Estrogen (Ers α) Expressionmentioning

confidence: 99%

Expression of estrogen receptors alpha (ERs α) and folliculogenesis profile in ovary of the rats ovarian hypofunction model

Firmawati

Hutabarat

Pratiwi

et al. 2021

JIIP

View full text Add to dashboard Cite

show abstract

Analysis of Immunoexpression of Estrogen Receptor Beta and Extracellular Matrix Metalloproteinase Inducer (Emmprin) on Testicular Seminomas Nonrecurrence and Recurrence

Abstract: The most common malignancy of testis is seminoma with prognosis that is not always

Cited by 1 publication

References 10 publications

Expression of estrogen receptors alpha (ERs α) and folliculogenesis profile in ovary of the rats ovarian hypofunction model

Expression of estrogen receptors alpha (ERs α) and folliculogenesis profile in ovary of the rats ovarian hypofunction model

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