Analysis of gibberellic acid, abscisic acid, indole‐3‐acetic acid and zeatin from the selected tissues of albino mice

Yavas, Ayse; Özmen, Murat; Topcuoglu, S.F.

doi:10.1080/02772249709358440

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Accumulation of significant amounts of Gibberellic acid in some tissues as kidney and liver of mice causes induction of oxidative stress in liver tissue [13,61,62] that might be due to release of reactive oxygen species (ROS) that can attack DNA, lipids, and thiols in proteins and causes cell dysfunction, genotoxic damage, and cell death. Accumulation of significant amounts of Gibberellic acid in some tissues as kidney and liver of mice causes induction of oxidative stress in liver tissue [13,61,62] that might be due to release of reactive oxygen species (ROS) that can attack DNA, lipids, and thiols in proteins and causes cell dysfunction, genotoxic damage, and cell death.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and effect of a new Terbium gibberellic complex on the histopathological alteration induced by Gibberellic acid on liver and kidney of mice Mus musculus

Seleem

Hussein

2018

Chem Biol Drug Des

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The objective of this study was to synthesize Gibberellic lanthanide complex and evaluate its biological activity to reduce the Gibberellic acid toxicity on liver and kidney. The new bis(Gibberellic)-nitro-terbium(III) complex was characterized by different analytical methods: elemental analyses, UV-Vis, molar ratio, fluorescence, FT-IR, and TGA-DTA measurements. Thirty newborns were classified into three groups control, Gibberellic acid, and Terbium gibberellic acid complex. Livers and kidneys of studied groups proceed for general histology and immunohistochemical staining of Cyr61, cytochrome C, and TNFR2. From the absorption titration measurements, the binding constants of DNA with Tb(III)-(GA) complex and free ligand were found to be 3.9 × 10 and 2.1 × 10 m , respectively, with the stoichiometry of 1:1. Hypochromism was observed from the absorption titration experiment which indicates the intercalation of Tb(III)-(GA) complex between the base pairs of DNA. Gibberellic acid-treated group showed alteration in the histological picture of livers and kidneys that accompanied with the reduction in the expression of Cyr61, cyt C, and TNFR2. The amelioration was observed in Gibberellic acid complex with Terbium group. The study concluded that Terbium gibberellic complex is less dangerous effects than Gibberellic acid alone.

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Section: Discussionmentioning

confidence: 99%

Synthesis and effect of a new Terbium gibberellic complex on the histopathological alteration induced by Gibberellic acid on liver and kidney of mice Mus musculus

Seleem

Hussein

2018

Chem Biol Drug Des

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“…A study on Swiss albino mice showed that GA3 accumulated in the hepatic, renal and brain tissues. The most significant damage occurred to the kidneys and GA3 caused lymphocytic interstitial cell infiltration (19). The earlier studies indicate that GA3 affects the vital organs and may lead to cancer and similar pathologies but provide no information on the mechanism responsible.…”

Section: Discussionmentioning

confidence: 95%

Effect of Gibberellic Acid on the Levels of Tumor Necrosis Factor-α, Interleukin-4 and Interleukin-10 in Rats

Öztürk¹,

Erin²,

Balcı³

2019

Turk J Endocrinol Metab

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Objective: Gibberellic acid is a plant growth factor. Several studies have demonstrated the effect of gibberellic acid on tumor development. Tumor necrosis factor-α, interleukin-4 and interleukin-10 are important cytokines involved in the regulation or prevention of cancer. The aim of this study was to investigate whether changes in cytokine balance have any role in the tumor-inducing effect of gibberellic acid. Material and Methods: In order to examine the acute and subchronic effect of gibberellic acid, 50 male Wistar rats were divided into five groups. For the subchronic treatments, the first group received 2 mg/kg gibberellic acid, the second group received 20 mg/kg gibberellic acid, and the third group received only the solvent via intraperitoneal injections given three times a week for a 30 days. In the acute treatment group, a single does of either 20 mg/kg gibberellic acid or the solvent alone was administered via intraperitoneal injection, and the tissues were dissected three hours after the injection. Results: During the study period (30 days), both doses of gibberellic acid resulted in a decrease in Tumor necrosis factor-α levels, and a dose-dependent decrease in interleukin-4 levels was observed. However, no change was observed in interleukin-10 levels. Conclusion: We conclude that gibberellic acid influenced the cytokine balance. The resulting changes may be responsible for the development or advancement of inflammatory diseases and malignancies.

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Oxidative stress induced by gibberellic acid in bone of suckling rats

Troudi

Amara

Soudani

et al. 2011

Ecotoxicology and Environmental Safety

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Analysis of gibberellic acid, abscisic acid, indole‐3‐acetic acid and zeatin from the selected tissues of albino mice

Cited by 5 publications

References 18 publications

Synthesis and effect of a new Terbium gibberellic complex on the histopathological alteration induced by Gibberellic acid on liver and kidney of mice Mus musculus

Synthesis and effect of a new Terbium gibberellic complex on the histopathological alteration induced by Gibberellic acid on liver and kidney of mice Mus musculus

Effect of Gibberellic Acid on the Levels of Tumor Necrosis Factor-α, Interleukin-4 and Interleukin-10 in Rats

Oxidative stress induced by gibberellic acid in bone of suckling rats

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