Analysis of gene expression in Homarus americanus larvae exposed to sublethal concentrations of endosulfan during metamorphosis

Bauer, Megan; Greenwood, Spencer J.; Clark, Kevin; Jackman, Paula; Fairchild, Wayne L.

doi:10.1016/j.cbd.2013.07.002

Cited by 14 publications

(11 citation statements)

References 36 publications

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“…In fact, EN is classified as extremely toxic substance according to WHO (Tomlin, 2000). Our results agree with Echeverría-Sáenz et al (2012) and Bauer et al (2013) who found increased fish mortality due to high levels of insecticides in water.…”

Section: Discussionsupporting

confidence: 91%

Toxicity of Amoxicillin and Erythromycin to Fish and Mosquito

El‐Nahhal

EL-dahdouh²

2015

Ecotoxicol. Environ. Contam.

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This study characterized the toxicity of Amoxicillin (AM), Erythromycin (ER) and Endosulfan (EN) to fish and mosquito larvae obtained from a certified fish farm and from Wadi Gaza. The acute toxicity tests were determined by calculating mortality percentage of fish and mosquitoes through a gradient concentration of the tested compounds. Mortality percentage, exposure time, LC 50 and LT 50 were taken as indicators of toxicity. The results showed that AM was the potent compound against fish with LC 50 value lower that EN. Toxicity to fish is in the following order: AM > EN > ER whereas the toxicity to mosquitoes is in the following order: ER > EN > AM. Fish are more sensitive to AM than mosquitoes whereas mosquitoes are more sensitive to ER than fish. The interesting outcome of the study is the calculated LC 50 values are far below the concentration found in different water systems. Mixture toxicity of the tested antibiotics indicates antagonistic effect on both fish and mosquitoes.

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Section: Discussionsupporting

confidence: 91%

Toxicity of Amoxicillin and Erythromycin to Fish and Mosquito

El‐Nahhal

EL-dahdouh²

2015

Ecotoxicol. Environ. Contam.

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“…Gene expression analysis could provide interesting insights in order to detect molecular dysfunctions related to some hormones related to growth or metabolic functions. It was shown that a 14 days exposure to endosulfan changes significantly the expression of genes related to molt processes such as FTZ-F1 and FAO-MeT (Bauer et al, 2013). Genes involved in Ca 2+ regulation were also down regulated that could impair exoskeleton development (Bauer et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Impact of an Acute Sublethal Exposure of Endosulfan on Early Juvenile Lobster (Homarus americanus)

Daoud¹,

Fairchild

Comeau

et al. 2014

AST

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Anthropogenic chemicals in the environment during critical periods could potentially affect the physiology of the economically valuable American lobster (Homarus americanus). Endosulfan (Thiodan™ WP) is a broad-spectrum organochlorine insecticide widely used in agricultural areas in Canada that significantly affects survival and growth of lobster larvae based on acute exposure studies. To detect more subtle physiological effects of an acute (96-h) sub-lethal level (0.1 μg•L-1) of formulated endosulfan exposure on early juvenile lobsters, investigations of metabolic rates, growth and the tissue structure of the

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“…Bauer et al (2013) exposed American lobster larvae to endosulfan, a widely used organochlorine pesticide that acts as an endocrine disruptor and prevents molting in crustaceans (Zou and Fingerman, 1997). Endosulfan exposure resulted in developmental delays in reaching metamorphosis and significant effects on genes linked to biological processes such as development, metabolism, gene regulation, immune and oxidative stress response (Bauer et al, 2013).…”

Section: Discussionmentioning

confidence: 99%