Analysis of Fusarium toxins in feed

Krska, Rudolf; Welzig, Elvira; Boudra, Hamid

doi:10.1016/j.anifeedsci.2007.06.004

Cited by 155 publications

(118 citation statements)

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“…Concerning the analytical determination of Fusarium mycotoxins in feed and, among them, NIV, only one updated review was found in literature (Krska et al, 2007b).…”

Section: Methodsmentioning

confidence: 99%

“…The lack of the carbonyl group tends to make type A trichothecenes more toxic (Smith and Solomons, 1994). The type A trichothecenes include T-2 toxin (T-2), HT-2 toxin (HT-2), neosolaniol (NEO), diacetoxyscirpenol (DAS) and monoacetoxyscirpenol (MAS), while type B trichothecenes include deoxynivalenol (DON, also known as vomitoxin) and its 3-acetyl and 15-acetyl derivatives (3AcDON and 15AcDON, respectively), nivalenol (NIV) and fusarenon X (FusX) (Krska et al, 2007b). The synthesis of the two types of trichothecenes appears to be characteristic of a particular Fusarium species.…”

Section: -467mentioning

confidence: 99%

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Scientific information on mycotoxins and natural plant toxicants

Battilani

Costa

Dossena

et al. 2009

EFSA Supporting Publications

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“…Concerning the analytical determination of Fusarium mycotoxins in feed and, among them, NIV, only one updated review was found in literature (Krska et al, 2007b).…”

Section: Methodsmentioning

confidence: 99%

Section: -467mentioning

confidence: 99%

Scientific information on mycotoxins and natural plant toxicants

Battilani

Costa

Dossena

et al. 2009

EFSA Supporting Publications

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“…It is produced as a secondary metabolite by a number of Fusarium species, including Fusarium culmorum and Fusarium graminearum (Hestbjerg et al, 2002;Glenn, 2007), and is common in maize and wheat (Yamashita et al, 1995;Binder et al, 2007;Krska et al, 2007). Among domestic animals and poultry, prepubertal female pigs appear to be the most sensitive to ZEA (Fink-Gremmels and Malekinejad, 2007).…”

Section: Introductionmentioning

confidence: 99%

Soybean isoflavone reduces the residue of zearalenone in the muscle and liver of prepubertal gilts

Wang

Zhou

Hou

et al. 2013

Animal

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The aim of the present study was to evaluate the protective effects of isoflavone (ISO) against zearalenone (ZEA) residues in the muscle and liver tissues of prepubertal gilts. Seventy 75-day-old, prepubertal, female pigs (Duroc 3 Landrace 3 Yorkshire, 26.5 6 0.60 kg) were allocated randomly to seven diet treatments for 21days as follows: one control group (fed the basal diet) and six groups fed the basal diet with the addition of either 0.5 or 2.0 mg/kg ZEA plus either 0, 300 or 600 mg/kg ISO. The results showed that the diet with 2.0 mg/kg ZEA added caused an increase of ZEA residue level in muscle tissue (P , 0.05), and that the addition of both 0.5 and 2.0 mg/kg ZEA increased the residue level of ZEA in the liver of prepubertal gilts (P , 0.05). Addition of 600 mg/kg ISO to 2.0 mg/kg ZEA-contaminated diet decreased the ZEA residue level in liver tissue (P , 0.05), and the addition of 300 or 600 mg/kg ISO to the 2.0 mg/kg ZEA-contaminated diet decreased the residue levels of ZEA in muscle tissue (P , 0.05). Western blot analysis demonstrated that feeding ZEA to prepubertal gilts increased their protein expression of 3a/3b-hydroxysteroid dehydrogenase (HSD; P , 0.05), and that the addition of 300 or 600 mg/kg ISO to the 2.0 mg/kg ZEA-contaminated diet decreased the protein expression of 3a/3b-HSD (P , 0.05), compared with the addition of 2.0 mg/kg ZEA alone. The results demonstrated that muscle and liver tissues retain residual ZEA when pigs are fed a diet contaminated with high concentrations of ZEA, and that the concentration of ZEA in muscle and liver tissues increased with increased amounts of ZEA in the feed. In diets contaminated with high levels of ZEA, the addition of ISO may accelerate the biotransformation and degradation of ZEA and its metabolites, and reduce the residues of ZEA in liver and muscle tissues of prepubertal gilts.Keywords: soybean isoflavone, prepubertal gilts, zearalenone residue, 3a/3b-HSD expression ImplicationsMaize and soybean are two of the principle ingredients in animal feed, and as such zearalenone (ZEA) and soybean isoflavones (ISOs) are often found together in maize-soybean meal-based feed. Our study shows that diets containing ISO may accelerate the biotransformation and degradation of ZEA and its metabolites, and thus reduce the residues of ZEA in liver and muscle tissues. These findings suggest a potential means of mitigating the negative effects of high concentration of ZEA contamination in feed.

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“…Trichothecenes are multi-ring sesquiterpenes with a common 12,13-epoxytrichothecene ring (Krska et al 2007;Yazar and Omurtag 2008;Monaci et al 2011;Mateo et al 2002). Because of some subtle but significant differences in basic chemical structures, they have been classified into four types referred to as types A, B, C and D trichothecenes, of which the first two are the most important ones (Berthiller et al 2005;Charlton and Holstege 2010).…”

Section: Introductionmentioning

confidence: 99%

An LC-IT-MS/MS-Based Method to Determine Trichothecenes in Grain Products

et al. 2013

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The aim of this work was to evaluate the usefulness of the ion trap mass spectrometry coupled to high-performance liquid chromatography for simultaneous determination of selected trichothecenes (nivalenol, deoxynivalenol, fusarenon-X, neosolaniol, 3-acetyl-deoxynivalenol, diacetoxyscirpenol, HT-2 and T-2 toxins) in grain products. These compounds were extracted from the grain products and then cleaned up with the developed, simple and robust procedure using some mixture of neutral alumina, charcoal and diatomaceous earth. Method recovery was 88-125 % depending on combination of the analysed mycotoxins, sample matrix and the fortification level. Method precision expressed by relative standard deviation ranged from 2.6 to 27.4 %. The concentrations of the selected trichothecenes have been determined in 94 samples of cerealbased products. Maize-based next to wheat-based products were the most contaminated with deoxynivalenol, neosolaniol, 3-acetyl-deoxynivalenol, diacetoxyscirpenol and HT-2 toxin. In 83 % of wheat-based products, deoxynivalenol was determined at the average level of 249 μg kg −1 . The highest concentration of deoxynivalenol-2,026 μg kg −1 (476±471 μg kg −1 on the average)-was found in the maize-based product. Other mycotoxins were found much less frequently: 3-acetyl-deoxynivalenol in only one sample at the concentration of 59 μg kg −1 , neosolaniol, HT-2 toxin and diacetoxyscirpenol in a few samples on average concentrations close to respective limits of quantification.

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Analysis of Fusarium toxins in feed

Cited by 155 publications

References 112 publications

Scientific information on mycotoxins and natural plant toxicants

Scientific information on mycotoxins and natural plant toxicants

Soybean isoflavone reduces the residue of zearalenone in the muscle and liver of prepubertal gilts

An LC-IT-MS/MS-Based Method to Determine Trichothecenes in Grain Products

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