Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia

Forero, Diego A.; Benítez, Bruno A.; Arboleda, Gonzalo; Londoño, Juan José Yunis; Pardo, Rodrigo; Arboleda, Humberto

doi:10.1016/j.neures.2006.04.006

Cited by 46 publications

(30 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported five positive results (12-16) and 21 negative results (19,(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) between the BDNF Val66Met polymorphism and AD. In the present meta-analysis, no significant association was found between BDNF Val66Met and AD (P>0.05, Table II).…”

Section: Discussionmentioning

confidence: 99%

“…Inconsistent results have been reported in the previous studies on the association of BDNF and BCHE polymorphisms with AD. For BDNF Val66Met, there have been five positive results in Europeans (12)(13)(14)(15) and Asians (16), and 21 negative results (among 18 studies) in Europeans (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), Asians (19,(38)(39)(40)(41)(42) and Africans (29). For BDNF C270T, there have been four positive results in Europeans (13,17) and Asians (18,19) and 14 negative results in Europeans (28)(29)(30)(31)(34)(35)(36)(37)(43)(44)(45), Asians (40,41) and Africans (29).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 genetic case-control studies of 12,563 cases and 12,622 controls

Dai

Wang

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Alzheimer's disease (AD) is a common neurodegenerative disorder that can destroy the memory of sufferers and lead to distress for the individual and society. Brain-derived neurotrophic factor (BDNF) and butyrylcholinesterase (BCHE) are two genes associated with β-amyloid plaques and neurofibrillary tangles that are two key factors in the pathophysiology of AD. The aim of the current meta-analysis was to evaluate the association between BDNF Val66Met (rs6265), BDNF C270T (rs2030324) and BCHE-K (rs1803274) polymorphisms and AD. A comprehensive meta-analysis was performed using the online database PubMed without a time limitation. A total of 56 articles evaluating 12,563 cases and 12,622 controls were selected for the current meta-analysis. The results showed a moderate association of the BDNF C270T polymorphism with the risk of AD in Asians under a dominant model (P=0.03; odds ratio, 1.88; 95% confidence interval, 1.08-3.27). No other significant association was found during the meta-analysis for the other two polymorphisms (P>0.05). The current meta-analysis suggests that BDNF C270T is a risk factor for AD in Asians. This meta-analysis has been, to the best of our knowledge, the most comprehensive meta-analysis of BDNF Val66Met, BDNF C270T and BCHE-K to date.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 genetic case-control studies of 12,563 cases and 12,622 controls

Dai

Wang

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Moreover, the A allele of rs6265 has also found to be associated with poorer episodic memory, abnormal hippocampal activation, and lower hippocampal n-acetyl aspartate (NAA) in human subjects [66]. Individual studies have reported 10 positive results [32,39,41,42,46,49,50,53,57,67] and 22 negative results [30,31,[33][34][35][36][37][38]40,45,47,48,51,[54][55][56]58,59,68] among the previous association studies between the BDNF G196A polymorphism and AD. In the present meta-analysis, no significant association was found between BDNF G196A and AD (P>0.05, Figures 2-5).…”

Section: Discussionmentioning

confidence: 99%

Association of Brain-Derived Neurotrophic Factor (BDNF) Gene Snps G196A and C270T with Alzheimer’s Disease: A Meta-Analysis

Shovit¹,

Ks²

2017

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

“…The brain-derived neurotrophic factor (BDNF) gene encodes a neurotrophin involved in synaptic and neural plasticity in the adult brain [8,9]. The BDNF gene is located in chromosome 11, has 8 exons, spans 65 kbp and encodes a secreted protein of 247 amino acids [10].…”

Section: Introductionmentioning

confidence: 99%

“…The COMT gene is located in chromosome 22, has 6 exons, spans 27 kbp, and encodes a protein of 271 amino acids (182 aa for the soluble isoform) [11]. A functional polymorphism in the COMT gene (rs4680, g.19.951.271G>A), changing a Val to Met in codon 158 (table 1), is frequently studied in a large number of neuropsychiatric phenotypes, with the Met isoform known to have a lower enzymatic activity [8,12]. …”

Section: Introductionmentioning

confidence: 99%

Functional Polymorphisms in BDNF and COMT Genes Are Associated with Objective Differences in Arithmetical Functioning in a Sample of Young Adults

González-Giraldo

Rojas²,

Novoa³

et al. 2014

Neuropsychobiology

Self Cite

View full text Add to dashboard Cite

Background: Understanding the molecular genetics of complex human behaviors and functions remains a substantial challenge for the neurosciences. Previous studies have shown a genetic basis for individual differences in mathematical functioning; however, the specific genes remain to be completely identified. In the present study, we explored the possibility that 2 functional polymorphisms in candidate genes could be associated with differences in arithmetical performance. Methods: A computerized test to analyze performance in basic arithmetical calculations (additions and subtractions) was applied to 168 healthy young Colombian participants using the PEBL (Psychology Experiment Building Language) battery. DNA samples were genotyped for 2 functional SNPs in candidate genes: brain-derived neurotrophic factor (BDNF)-Val66Met and catechol-O-methyltransferase (COMT)-Val158Met. Results: We found significant differences for arithmetical processing scores between genotypes. For BDNF, Val/Val subjects had a worse performance (p value: 0.025) and for COMT, Val/Val carriers had a better performance (p value: 0.006). A multivariate model, including both BDNF and COMT genes, accounted for 7.1% of the variance in math processing scores. Discussion: To our knowledge, this is the first study finding associations of polymorphisms in BDNF and COMT genes with quantitative measures of numerical aptitude in healthy young participants. A future study of other genes involved in neural plasticity could be helpful to identify genetic correlates of arithmetical functioning, which will be important for the understanding of normal human behaviors and related neuropsychiatric disorders.

show abstract

Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia

Cited by 46 publications

References 79 publications

Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 genetic case-control studies of 12,563 cases and 12,622 controls

Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 genetic case-control studies of 12,563 cases and 12,622 controls

Association of Brain-Derived Neurotrophic Factor (BDNF) Gene Snps G196A and C270T with Alzheimer’s Disease: A Meta-Analysis

Functional Polymorphisms in BDNF and COMT Genes Are Associated with Objective Differences in Arithmetical Functioning in a Sample of Young Adults

Contact Info

Product

Resources

About