Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil

Abstract

After inhalation experiments with sandalwood oil and the pure fragrance compounds coumarin and alpha-terpineol, substances were detected and measured in the blood samples of test animals (mice) using gas chromatography/mass spectrometry (GC/MS) (MID) in connection with GC/FTIR (SWC), GC/AES (carbon and oxygen trace) and flame ionization detection/gas chromatography. Using tiglinic acid benzyl ester as the internal standard the following concentrations in serum could be found: alpha-santalol 6.1 ng/mL, beta-santalol 5.3 ng/mL and alpha-santalene 0.5 ng/mL. In separate inhalation experiments with coumarin and with alpha-terpineol the corresponding concentrations were 7.7 ng/mL and 6.9 ng/mL, respectively.

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

“…However, their ability to volatize and to enter human blood following inhalation or dermal administration makes this group, especially antimicrobially active group members, worthwhile to consider. [257][258][259] The recognition of antimicrobial activities of a compound in complex mixtures as they are obtained from crude plant extracts or essential oil distillates is the key step. TLC separation and subsequent testing of antifungal activity have been worked out for essential oils 60 and plant extracts 59 and led to the identification of potent anticandidal compounds, see Table II.…”

Any Sense in Classroom Scents? Aroma of Rosemary Essential Oil Significantly Improves Cognition in Young School Children

“…The pharmacological mechanism suggests that active volatile compounds enter the blood stream via the nasal or lung mucosa. Although the levels of absorbed molecules may be relatively low, such constituent compounds of essential oils have been recorded in the blood of rodents [48], and humans [41] following exposure to vapours of essential oils. Moreover, in the human trial, recorded serum levels of 1,8 cineole (the major volatile constituent of Rosemary essential oil) correlated with cognitive performance for some, but not all tasks included in the study.…”

The Therapeutic Benefits of Essential Oils

“…For example, after oral administration of (-)-menthol, 35% of the original menthol content was excreted renally as menthol glucuronide (Bronaugh et al, 1990;Buchbauer, 1993;Hotchkiss et al, 1990;Jirovetz et al, 1992;Kohlert et al, 2000).…”