Analysis of foetal expression sites of human type II DNA topoisomerase α and β mRNAs by in situ hybridisation

Zandvliet, Dorothea W.J.; Hanby, Andrew M.; Austin, Caroline A.; Marsh, Katherine L.; Clark, Ivan B. N.; Wright, Nicholas; Poulsom, Richard

doi:10.1016/0167-4781(96)00063-2

Cited by 42 publications

(34 citation statements)

References 24 publications

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“…16 The 11q23 locus is particularly sensitive to cleavage after treatment with topoisomerase-II inhibitors. As DNA topoisomerase-II seems to be highly expressed in developing fetuses, 17 exposure to DNA topoisomerase-II inhibitors could induce MLL rearrangements in utero. The most abundant environmental source of DNA topoisomerase-II inhibitors is diet.…”

Section: Etiology Of Mll Rearrangementsmentioning

confidence: 99%

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

et al. 2011

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Translocations involving the mixed-lineage leukemia (MLL) gene, localized at 11q23, comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases. This review summarizes current knowledge about the etiology, biology, clinical characteristics and differences in outcome in MLL-rearranged pediatric AML. Furthermore, we discuss the role of cooperating events in MLL-rearranged pediatric AML, and future therapeutic strategies to improve outcome. We conclude that MLL-rearranged pediatric AML is a heterogeneous disease, and prognosis depends on various factors, for example, translocation partner, age, WBC and additional cytogenetic aberrations. The relationship of outcome with specific translocation partners requires that they be searched for in the diagnostic work-up of AML. To achieve further improvements in outcome, unraveling the biology of MLL-rearranged pediatric AML is warranted.

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Section: Etiology Of Mll Rearrangementsmentioning

confidence: 99%

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

et al. 2011

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“…0.7 ϫ 10 9 cpm/µg RNA using T7 RNA polymerase. Pre-treatment, hybridisation washing and coating of slides were carried out as described elsewhere (Senior et al, 1988;Zandvliet et al, 1996). As a positive control for the presence of non-degraded, hybridisable RNA in all tissue compartments examined, we used a human ␤-actin probe (Zandvliet et al, 1996).…”

Section: In Situ Hybridisationmentioning

confidence: 99%

Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells

et al. 1999

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“…Of particular interest are substances that alter the function of the DNA topoisomerase II (DNAt2) enzyme, which relaxes supercoiled DNA by transiently cleaving and religating both strands of the double helix (7) and is highly expressed in developing fetuses (8). Epipodophyllotoxins have been used to treat a variety of cancers (9) because they disrupt the normal cleavage-religation reaction of DNAt2, which has the overall effect of enhancing cleavage, and the resultant DNA double-strand breaks lead to apoptosis (7).…”

Section: Introductionmentioning

confidence: 99%

Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group

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Xie

Robison

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The MLL 11q23 translocation arises in utero and is present in 75% of infant leukemias. That MLL+ acute myeloid leukemia (AML) can arise following chemotherapy with DNA topoisomerase II (DNAt2) inhibitors suggests that these substances, which also occur naturally in foods, may contribute toward infant leukemia. We hypothesized that maternal consumption of dietary DNAt2 inhibitors during pregnancy would increase the risk of infant leukemia, particularly AML(MLL+). Methods: This Children's Oncology Group case-control study consisted of 240 incident cases of infant acute leukemia [AML and acute lymphoblastic leukemia (ALL)] diagnosed during 1996 to 2002 and 255 random digit dialed controls. Maternal diet during pregnancy was determined through a food frequency questionnaire. An index of specific foods identified a priori to contain DNAt2 inhibitors as well as vegetables and fruits were created and analyzed using unconditional logistic regression.

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Analysis of foetal expression sites of human type II DNA topoisomerase α and β mRNAs by in situ hybridisation

Cited by 42 publications

References 24 publications

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells

Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group

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