Analysis of Fd Antigen in Gamma and Mu Paraproteins with Shared Idiotypy

Henley, Walter L.

doi:10.3181/00379727-142-37140

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1975

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“…This fragment contained part of the VH region of He, CHI in full, and part of CH2. The authors claimed anti-Fdy specificity of the antisera produced; in addition, they could show that the amino acids extending into He-VH and into Fc were not Involved (12,13). This localizes the antigenic determinant(s) between residues 120 and 216 of the human y chain, representing the CHI domain of Ig.…”

Section: Discussionmentioning

confidence: 97%

Studies on Fd Fragments of Human Immunoglobulins

1975

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Earlier studies on antisera against Fab of pooled human IgG and IgA myeloma proteins disclosed the presence of class-specific Fd antibodies, the demonstration of which required interaction of heavy and light chains. To extend our knowledge about the antigenic structure of the Fd fragment of human immunoglobulins, antisera were prepared in rabbits against gamma chains of pooled IgG and of four IgG1 myeloma proteins, and Fd gamma fragment and a cyanogen bromide-produced CH1 preparation of an IgG1 myeloma protein, and an Fd' alpha fragment of an IgA1 myeloma protein. No antigenic determinants exclusively confined to the CH1 region of intact human IgG could be demonstrated with these antisera. The antigenic structure of CH1 intact immunoglobulins may thus only be defined by light-chain-dependent determinants.

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Section: Discussionmentioning

confidence: 97%