Analysis of expression pattern of serum microRNA levels in patients with psoriasis

Koga, Yusaku; Jinnin, Masatoshi; Ichihara, Asako; Fujisawa, Akihiko; Moriya, Chikako; Sakai, Keisuke; Fukushima, Satoshi; Inoue, Yoshio; Ihn, Hironobu

doi:10.1016/j.jdermsci.2014.01.005

Cited by 24 publications

(23 citation statements)

References 10 publications

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“…In contrast to the upregulated miRNAs in psoriasis, miR-125b is decreased in the skin (Lovendorf et al, 2015;Sonkoly et al, 2007;Xu et al, 2011) and serum of patients with psoriasis (Koga et al, 2014). Decreased expression of miR-125b in psoriasis skin compared with normal skin is primarily the result of decreased expression in keratinocytes (Xu et al, 2011).…”

Section: Mir-125bmentioning

confidence: 94%

“…Regulation of inflammation, STAT3 signaling, and keratinocyte proliferation/differentiation (Lerman et al, 2011;Primo et al, 2012;Raaby et al, 2015;Sonkoly et al, 2007;Wei et al, 2013;Yi et al, 2008;Zibert et al, 2010) miR (Koga et al, 2014;Lovendorf et al, 2015;Sonkoly et al, 2007;Xu et al, 2011) Abbreviations: NF-kB, nuclear factor kappa-light-chain-enhancer of activated B cells; PBMCs, peripheral blood mononuclear cells; STAT3, signal transducer and activator of transcription 3; TGF-b1, transforming growth factor-b1.…”

Section: Mir-221 and Mir-222mentioning

confidence: 99%

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microRNAs in Psoriasis

Hawkes

Nguyen

Fujita

et al. 2016

Journal of Investigative Dermatology

121

106

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Psoriasis is a chronic inflammatory skin condition resulting from a complex interplay among the immune system, keratinocytes, susceptibility genes, and environmental factors. However, the pathogenesis of psoriasis is not completely elucidated. microRNAs represent a promising class of small, noncoding RNA molecules that function to regulate gene expression. Although microRNA research in psoriasis and dermatology is still relatively new, evidence is rapidly accumulating for the role of microRNAs in the pathogenesis of psoriasis and other chronic inflammatory conditions. In this article, we present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis.

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Section: Mir-125bmentioning

confidence: 94%

Section: Mir-221 and Mir-222mentioning

confidence: 99%

microRNAs in Psoriasis

Hawkes

Nguyen

Fujita

et al. 2016

Journal of Investigative Dermatology

121

106

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show abstract

“…On the other hand, we also focused on the combination of miRNA levels in the sera of psoriasis: Serum levels of six miRNA (miR-21-5p, -24-3p, -125b-5p, -146a-5p, 203a-3p and -205-5p) were determined by real-time PCR in 15 psoriasis patients, 15 atopic dermatitis patients and 15 normal subjects. 28 The order of six miRNA expression levels in the serum of each individual was different among psoriasis patients, atopic dermatitis patients and normal subjects. Combination of serum levels of miR-146a-5p and -203a-3p was more reliable to distinguish psoriasis patients and normal subjects than each miRNA alone, according to the ROC analysis.…”

Section: Psoriasismentioning

confidence: 99%

Recent progress in studies of miRNA and skin diseases

Jinnin

2015

The Journal of Dermatology

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miRNA is a family of small non-coding RNA that consists of 22 nucleotides on average. miRNA are implicated in various cellular activities such as cell proliferation or migration via the modulation of gene expression, and also are linked to the pathogenesis of human diseases. This paper reviews recent research progress about the contribution of miRNA to the pathogenesis of various skin diseases, and possible application of miRNA as the disease markers in each disease. For example, downregulated miR-424-5p in psoriatic skin causes the overexpression of MEK1 and cyclin E1 in psoriatic keratinocytes, resulting in the keratinocyte overgrowth and hyperproliferation seen in the disease. Although there was no significant difference in the serum miR-424-5p levels between psoriasis patients and healthy controls, serum miR-1266-5p levels were significantly upregulated in psoriasis patients, and showed weak and inverse correlation with disease activity. Furthermore, combination of serum levels of miR-146a-5p and -203a-3p was more reliable to distinguish psoriasis patients and normal subjects, than each miRNA alone. Hair shaft miR-424-5p levels were significantly higher in psoriasis patients than normal subjects, while hair root miR-19a-3p levels in psoriasis patients were inversely correlated with the duration between symptom onset and the first visit to the hospital. Future researches of miRNA will enable the advances of their clinical applications including the clarification of pathogenesis, disease markers and novel treatments.

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“…In recent years, there have been evidences implying the role of miRNAs in the pathogenesis of psoriasis based on studies on miRNAs expression in the skin, peripheral blood mononuclear cells, or serum [50]. Further studies are needed to elucidate miRNAs mechanisms of action, which may be useful for novel therapeutic approaches.…”

Section: New Therapeutic Targets For Psoriasismentioning

confidence: 99%