microRNAs in Psoriasis

Hawkes, Jason E.; Nguyen, Giang Huong; Fujita, Mayumi; Florell, Scott R.; Duffin, Kristina Callis; Krueger, Gerald G.; O’Connell, Ryan M.

doi:10.1038/jid.2015.409

Cited by 123 publications

(111 citation statements)

References 85 publications

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“…Numerous studies have focused on the assessment of miRNA expression and have shown considerable changes in their expression profiles in various diseases (17)(18)(19)(20), although the most remarkable changes have been observed in cancer (21)(22)(23)(24). The results of these studies point to the profiling of miRNA expression as an important tool for the prognosis, diagnosis and treatment of diseases (18,25,26).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic regulation mechanisms of microRNA expression

Morales

Monzó

Navarro

2017

Biomolecular Concepts

115

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MicroRNAs (miRNAs) are single-stranded RNAs of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. They are involved in many physiological and pathological processes, including cell proliferation, apoptosis, development and carcinogenesis. Because of the central role of miRNAs in the regulation of gene expression, their expression needs to be tightly controlled. Here, we summarize the different mechanisms of epigenetic regulation of miRNAs, with a particular focus on DNA methylation and histone modification.

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Section: Introductionmentioning

confidence: 99%

Epigenetic regulation mechanisms of microRNA expression

Morales

Monzó

Navarro

2017

Biomolecular Concepts

115

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“…In psoriasis, miRNA expression disorders have been reported [31, 32]. To date, more than 250 miRNAs have been reported as aberrantly expressed in psoriasis tissue, the majority of which are found in peripheral blood or involved psoriatic skin, but only small subsets of these dysregulated miRNAs in psoriasis have confirmed mRNA targets with established biological functions in the skin [19]. In the present study, we determined the expression level and detailed function of miR-150, which was reported to be down-regulated in psoriasis tissues [20].…”

Section: Discussionmentioning

confidence: 99%

“…Basically, miRNAs exert their functions through binding to the 3’UTR of target mRNA genes and subsequently disrupts translation or triggers mRNA degradation [19]. Excessive proliferation of keratinocytes in psoriasis causes local environmental hypoxia, leading to increased expression of HIF-1α [12]; microenvironment hypoxia accelerates vascular growth to supply the oxygen required for cell growth, along with the elevated expression of VEGFA during this process [33].…”

Section: Discussionmentioning

confidence: 99%

“…MiRNAs have been shown to play pivotal roles in diverse developmental and cellular processes implicated in a variety of many autoimmune diseases including psoriasis [17, 18]. In previous studies, miRNAs abnormal expression was frequently reported in psoriasis [19], including miR-99a, miR-150, miR-423 and miR-197 [20]. In the present study, we determined the expression level of miR-150 in lesional psoriatic skin tissues compared with non-lesional psoriatic skin tissues, and validated the detailed role of miR-150 in human keratinocytes’ proliferation.…”

Section: Introductionmentioning

confidence: 99%

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MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1α and VEGFA: Implications for psoriasis treatment

et al. 2017

PLoS ONE

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Psoriasis is a common and chronic autoimmune skin disease which affects 2 to 3% of the world population. Abnormal proliferation of human keratinocytes is an important feature of psoriasis, along with local hypoxia and vascular abnormal growth. To leverage recent molecular findings into the personalized treatment of psoriasis, we need a strategy that integrates clinical stratification with molecular phenotyping. MicroRNAs (miRNAs) are a large family of small non-coding RNA which regulates diverse biological process, including cell proliferation, by modulating gene expression at the posttranscriptional level. In the present study, we indicated that miR-150 specifically down-regulated expressed in psoriatic skin lesions, and could inhibit HaCaT cells and primary adult human keratinocytes (HKCs)’ proliferation in either normal or hypoxia conditions; by direct targeting, miR-150 could also regulate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor A (VEGFA). In addition, we found that HIF-1α and VEGFA were highly expressed in the lesional psoriatic skin compared with the non-lesional psoriatic skin, and negatively correlated with miR-150 expression. Taken together, we indicated miR-150 regulates human keratinocytes’ proliferation in hypoxic conditions through targeting HIF-1α and VEGFA in psoriasis for the first time, and provide diagnostic markers and a novel target for psoriasis treatment.

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“…5,6 Interestingly, aberrantly expressed miRNA are disclosed to be involved in regulation of hyperproliferation, abnormal differentiation of keratinocytes and disordered activation of immunity. 5,6 Interestingly, aberrantly expressed miRNA are disclosed to be involved in regulation of hyperproliferation, abnormal differentiation of keratinocytes and disordered activation of immunity.…”

Section: Introductionmentioning

confidence: 99%

Measurement of circulating miRNA‐125a exhibits good value in the management of etanercept‐treated psoriatic patients

Pei

Cao

Qin

et al. 2019

The Journal of Dermatology

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This study aimed to explore the correlation of miR-125a with risk and severity of psoriasis, and further investigate the potential of miR-125a for predicting response to etanercept (ETN) treatment in psoriatic patients. Moderate to severe plaque psoriatic patients (n = 126) about to undergo ETN treatment for 6 months were recruited. Their plasma samples were obtained, and Psoriasis Area and Severity Index (PASI) scores and PASI-75 response rate were assessed at baseline (M0), and at 1 (M1), 3 (M3) and 6 months (M6) of treatment. Referring to PASI-75 response status at M6, patients were categorized as PASI-75 responders and PASI-75 non-responders. Healthy controls (HC, n =120) were also enrolled and their plasma samples were collected. In addition, plasma miR-125a was determined by quantitative polymerase chain reaction. miR-125a was decreased in psoriatic patients compared with HC; further, the receiver-operator curve (ROC) exhibited that miR-125a was of good value in differentiating psoriatic patients from HC with an area under the curve (AUC) of 0.802. In psoriatic patients, miR-125a was negatively associated with PASI score to some extent. Interestingly, baseline miR-125a was lower in PASI-75 responders than PASI-75 non-responders; further, ROC showed it predicted PASI-75 response at M6 to some extent with AUC of 0.672. Multivariate logistic regression also revealed that miR-125a was an independent predictive factor for worse PASI-75 response at M6. Furthermore, miR-125a expression was gradually increased during the treatment in PASI-75 responders, but unchanged in PASI-75 non-responders. Measurement of circulating miR-125a exhibits good value in the management of ETN-treated psoriatic patients.

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microRNAs in Psoriasis

Cited by 123 publications

References 85 publications

Epigenetic regulation mechanisms of microRNA expression

Epigenetic regulation mechanisms of microRNA expression

MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1α and VEGFA: Implications for psoriasis treatment

Measurement of circulating miRNA‐125a exhibits good value in the management of etanercept‐treated psoriatic patients

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