Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis

Qiao, Jie; Chen, Cheng; Feng, Jiexiong; Dai, Xiyong; Xu, Feng; Xia, Peng

doi:10.1016/j.ijid.2022.03.020

Cited by 7 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 full papers were reviewed, different reports of the same clinical study and literature inconsistent with the content of this study were excluded, and references of relevant literature were searched to prevent literature omission. Finally, a total of 12 RCTs were included in the study [11][12][13][14][15][16][17][18][19][20][21][22][23][24]. All the retrieval and screening processes were completed by two evaluators independently, and any different opinions were unified through internal discussion (Table 1).…”

Section: Literature Retrieval Results and Included Researchmentioning

confidence: 99%

Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

Wang¹,

Zou

Zhang

2022

Emergency Medicine International

View full text Add to dashboard Cite

Objective. Levofloxacin has been widely used in clinical anti-infection treatment; however, its adverse reactions to levofloxacin were also obvious in patients. Herein we aimed to systematically evaluate the clinical efficacy and safety of systemic administration of levofloxacin in the prevention of postoperative infection after traumatic osteoarthrosis and internal fixation. Methods. PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP database, and Wanfang Database were searched from December 1993 to December 2021. Meanwhile, China ADR Information Bulletin and WHO Pharmaceutical were searched manually. Newsletter and FDA Drug Safety Newsletter, also to retrieve the Websites of Chinese, Chinese, and drug regulatory authorities; To obtain data on adverse events in children with systemic administration of levofloxacin. The literature was screened according to inclusion and exclusion criteria. The risk of bias was evaluated for the included RCT literature. Results. There was a statistical difference in the comparison of the incidence of fever between the experimental group and the control group (OR = 2.29, 95% CI (1.75,2.98), P < 0.00001 , I2 = 0%, Z = 6.11); elevated white blood cell count (OR = 1.82, 95% CI (1.31,2.52), P = 0.0003 , I2 = 0%, Z = 3.60); incidence of wound infection (OR = 2.11, 95% CI (1.54,2.90), P < 0.00001 , I2 = 0%, Z = 4.64); adverse drug reaction (OR = 1.82, 95% CI (1.21,2.74), P = 0.004 , I2 = 0%, Z = 2.86). Conclusion. In the clinical use of levofloxacin, adverse drug reactions including fever, elevated white blood cell count, and wound infection should be concerned.

show abstract

Section: Literature Retrieval Results and Included Researchmentioning

confidence: 99%

Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

Wang¹,

Zou

Zhang

2022

Emergency Medicine International

View full text Add to dashboard Cite

show abstract

“…32,33 Recent studies also recommend at least 12 months of treatment for patients with spinal TB. 33 Therefore, in our study, instead of setting the short course of anti-TB chemotherapy at 6 or 9 months, 29,32,34 or even an ultra-short course of 3 months, 35 as in other studies, the short course of treatment was set at less than or equal to 12 months. We believe this is more in line with the characteristics of the course of anti-TB treatment for Chinese patients under Chinese guidelines.…”

mentioning

confidence: 99%

Clinical Features and Outcomes of Spinal Tuberculosis in Central China

Tang¹,

Fu²,

Zhou³

et al. 2022

IDR

View full text Add to dashboard Cite

Purpose The appropriate management of spinal tuberculosis (TB) is challenging for clinicians and the key to treat spinal TB. Surgery and long course anti-TB chemotherapy may not be necessary to all situations. This study aimed to characterize the clinical features and factors affecting treatment outcomes. Patients and Methods A retrospective study of patients with spinal TB over a 5-year period at a teaching hospital in central China was conducted. Features of patients with spinal TB who received different treatment modalities and factors associated with patient outcomes at the end of chemotherapy were analyzed. Results Forty-five patients (21 men and 24 women) with spinal TB were available for analysis. The mean age was 55.39 ± 14.94 years. The most common vertebral area involved was the lumbar (42.2%). The mean number of vertebrae involved was 2.20 ± 0.59. 27 patients (60.0%) received surgical treatment, of which 21 (77.8%) received radical surgical treatment. Thirty-five patients (77.8%) had achieved a favorable status. Statistically, there was no significant correlation between favorable status and surgery, but among 27 surgical patients with spinal tuberculosis, patients receiving radical surgery tended to achieve good prognosis ( P = 0.010; odds ratio = 0.053; 95% confidence interval 0.006–0.493). Moreover, there was no significant difference between long course and short course of anti-TB chemotherapy in prognosis in different treatment modalities. Conclusion Although the patients with spinal TB who needed surgical treatment often got a better prognosis when they had radical surgery, surgery was not actually a factor for the favorable outcomes of patients with spinal TB. In different treatment modalities, there was no additional benefit in longer anti-TB chemotherapy periods.

show abstract

Side effects of drugs used in the treatment of tuberculosis and leprosy

Onakpoya

2023

Side Effects of Drugs Annual

View full text Add to dashboard Cite

Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis

Cited by 7 publications

References 24 publications

Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

Clinical Features and Outcomes of Spinal Tuberculosis in Central China

Side effects of drugs used in the treatment of tuberculosis and leprosy

Contact Info

Product

Resources

About