Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

Abstract

Objective. Levofloxacin has been widely used in clinical anti-infection treatment; however, its adverse reactions to levofloxacin were also obvious in patients. Herein we aimed to systematically evaluate the clinical efficacy and safety of systemic administration of levofloxacin in the prevention of postoperative infection after traumatic osteoarthrosis and internal fixation. Methods. PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP database, and Wanfang Database were searched from December 1993 to December 2021. Meanwhile, China ADR Information Bulletin and WHO Pharmaceutical were searched manually. Newsletter and FDA Drug Safety Newsletter, also to retrieve the Websites of Chinese, Chinese, and drug regulatory authorities; To obtain data on adverse events in children with systemic administration of levofloxacin. The literature was screened according to inclusion and exclusion criteria. The risk of bias was evaluated for the included RCT literature. Results. There was a statistical difference in the comparison of the incidence of fever between the experimental group and the control group (OR = 2.29, 95% CI (1.75,2.98), P < 0.00001 , I2 = 0%, Z = 6.11); elevated white blood cell count (OR = 1.82, 95% CI (1.31,2.52), P = 0.0003 , I2 = 0%, Z = 3.60); incidence of wound infection (OR = 2.11, 95% CI (1.54,2.90), P < 0.00001 , I2 = 0%, Z = 4.64); adverse drug reaction (OR = 1.82, 95% CI (1.21,2.74), P = 0.004 , I2 = 0%, Z = 2.86). Conclusion. In the clinical use of levofloxacin, adverse drug reactions including fever, elevated white blood cell count, and wound infection should be concerned.

Investigating how tamsulosin combined with levofloxacin impacts wound healing in patients with chronic prostatitis who may also have perineal or urethral wounds

“…Nevertheless, the intricate interplay between these two pharmaceuticals and their combined influence on the process of wound healing, specifically within the distinct domain of chronic prostatitis, remains ambiguous and necessitates comprehensive inquiry. 13,14 This research paper investigates the potential impact of levofloxacin, a broad-spectrum antibiotic, and tamsulosin, an alpha-blocker predominantly prescribed for the relief of urinary symptoms related to an enlarged prostate, on the process of wound healing in the aforementioned patients.…”

“…Conversely, the antibiotic characteristics of levofloxacin can significantly contribute to the prevention or treatment of wound infections, the critical determinant in initiation of wound healing process. Nevertheless, the intricate interplay between these two pharmaceuticals and their combined influence on the process of wound healing, specifically within the distinct domain of chronic prostatitis, remains ambiguous and necessitates comprehensive inquiry 13,14 …”

“…Nevertheless, the intricate interplay between these two pharmaceuticals and their combined influence on the process of wound healing, specifically within the distinct domain of chronic prostatitis, remains ambiguous and necessitates comprehensive inquiry. 13 , 14 …”

Effects of refined nursing interventions in the operating room on surgical‐site wound infection in patients with lung cancer: A meta‐analysis

“…Antimicrobials are commonly used clinically to prevent and treat perioperative infections; however, the use of antimicrobials tends to increase the metabolic burden on liver function and has a limited preventive effect 9,10 . Some studies have found that appropriate operating room nursing is beneficial for reducing the incidence of surgical‐site infection 11 .…”

“…Antimicrobials are commonly used clinically to prevent and treat perioperative infections; however, the use of antimicrobials tends to increase the metabolic burden on liver function and has a limited preventive effect. 9 , 10 Some studies have found that appropriate operating room nursing is beneficial for reducing the incidence of surgical‐site infection. 11 Refined nursing interventions in the operating room are key to the success of surgery and include proactively communicating with patients during the nursing period, conducting comprehensive preoperative assessments of all patients, actively controlling underlying diseases and preparing the patient for the surgery, as well as good control of medical equipment and disinfection norms to ensure the sterility of the surgical area, thus reducing the occurrence of infection and improving the quality of care.…”