Analysis of drugs in plasma samples from schizophrenic patients by column-switching liquid chromatography-tandem mass spectrometry with organic–inorganic hybrid cyanopropyl monolithic column

Domingues, Diego Soares; Souza, Israel Donizéti de; Queiroz, Maria Eugênia Costa

doi:10.1016/j.jchromb.2015.04.040

Cited by 34 publications

(19 citation statements)

References 45 publications

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“…Currently, medical application of MS is dominated by triple quadrupole MSs, which are generally used for analysis of specific metabolite classes, such as amino acids [149], neurotransmitters [150], steroids [151] and drugs and their metabolites [152,153]. With progress in metabolomics technology, which demands much broader metabolite coverage, other types of mass detectors are becoming more popular.…”

Section: Analytical Techniquesmentioning

confidence: 99%

Metabolomics technology and bioinformatics for precision medicine

Azad¹,

Shulaev²

2018

Briefings in Bioinformatics

112

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Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small group or even individual patients based on their genetics, environment and lifestyle. Precision medicine relies heavily on developments in systems biology and omics disciplines, including metabolomics. Combination of metabolomics with sophisticated bioinformatics analysis and mathematical modeling has an extreme power to provide a metabolic snapshot of the patient over the course of disease and treatment or classifying patients into subpopulations and subgroups requiring individual medical treatment. Although a powerful approach, metabolomics have certain limitations in technology and bioinformatics. We will review various aspects of metabolomics technology and bioinformatics, from data generation, bioinformatics analysis, data fusion and mathematical modeling to data management, in the context of precision medicine.

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Section: Analytical Techniquesmentioning

confidence: 99%

Metabolomics technology and bioinformatics for precision medicine

Azad¹,

Shulaev²

2018

Briefings in Bioinformatics

112

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“…Gas chromatography in conjunction with mass spectroscopy is often used in the analysis of lipid subsets ( Kaddurah-Daouk et al, 2007 ). LC-MS is often used to obtain the largest possible biochemical profile data subset where metabolite concentrations might cover a broad range of information with regard to disease pathophysiology ( Adamowicz and Tokarczyk, 2015 ; Domingues et al, 2015 ). In addition to standard high-sample throughput applications, NMR spectroscopy is a quantitative nondestructive, noninvasive, nonequilibrium-perturbing technique that delivers comprehensive data on solution-state molecular structures, including the atomic positions of isotopic labels (eg, 13 C, 15 N, or 2 H) in different isotopomers created during stable isotope tracer studies ( Fan and Lane, 2008 ).…”

Section: Analytical Tools For Metabolome Analysismentioning

confidence: 99%

Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders

Sethi

Brietzke

2015

IJNPPY

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One of the major concerns of modern society is to identify putative biomarkers that serve as a valuable early diagnostic tool to identify a subset of patients with increased risk to develop neuropsychiatric disorders. Biomarker identification in neuropsychiatric disorders is proposed to offer a number of important benefits to patient well-being, including prediction of forthcoming disease, diagnostic precision, and a level of disease description that would guide treatment choice. Nowadays, the metabolomics approach has unlocked new possibilities in diagnostics of devastating disorders like neuropsychiatric disorders. Metabolomics-based technologies have the potential to map early biochemical changes in disease and hence provide an opportunity to develop predictive biomarkers that can be used as indicators of pathological abnormalities prior to development of clinical symptoms of neuropsychiatric disorders. This review highlights different -omics strategies for biomarker discovery in neuropsychiatric disorders. We also highlight initial outcomes from metabolomics studies in psychiatric disorders such as schizophrenia, bipolar disorder, and addictive disorders. This review will also present issues and challenges regarding the implementation of the metabolomics approach as a routine diagnostic tool in the clinical laboratory in context with neuropsychiatric disorders.

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“…Hybrid monoliths with cyanopropyl or aminopropyl functionalities developed from a mixture of TEOS and 3‐cyanopropyltriethoxysilane or 3‐aminopropyltriethoxysilane (APTES) were recently applied as microextraction sorbents or as first dimensional capillary column of the column‐switching LC–MS/MS system . Cyanopropyl in comparison to more compact aminopropyl solid phase showed better mechanical stability and higher binding capacity for simultaneous analysis of antipsychotics, antidepressants, anticonvulsants, and anxiolytics in plasma samples of schizophrenic patients.…”

Section: Organic–silica Hybrid Monolithsmentioning

confidence: 99%

“…Cyanopropyl in comparison to more compact aminopropyl solid phase showed better mechanical stability and higher binding capacity for simultaneous analysis of antipsychotics, antidepressants, anticonvulsants, and anxiolytics in plasma samples of schizophrenic patients. They could be reused more than 100 times and improved selectivity was reported over commercially available alkyl functionalized microextraction sorbents .…”

Section: Organic–silica Hybrid Monolithsmentioning

confidence: 99%

Advances in the development and applications of organic–silica hybrid monoliths

Zajickova

2016

J of Separation Science

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This review will concentrate on recent progress (since 2013) toward preparation of organic-silica hybrid monoliths and their latest applications as extraction and separation media largely focusing on capillary liquid chromatography and capillary electrochromatography. Main emphasis will be given to advancement of approaches relying on the sol-gel chemistry of tetra- and tri-alkoxysilanes, sol-gel chemistry of alkoxysilanes and free-radical copolymerization with organic monomers, and free radical and ring-opening copolymerization of polyhedral oligomeric silsesquioxanes with organic monomers. Hybrid molecularly-imprinted polymer monoliths and hybrid monoliths made with non-silica-based precursors or in combination with metal alkoxides will be included as well.

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Analysis of drugs in plasma samples from schizophrenic patients by column-switching liquid chromatography-tandem mass spectrometry with organic–inorganic hybrid cyanopropyl monolithic column

Cited by 34 publications

References 45 publications

Metabolomics technology and bioinformatics for precision medicine

Metabolomics technology and bioinformatics for precision medicine

Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders

Advances in the development and applications of organic–silica hybrid monoliths

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