Analysis of DNA Mismatch Repair Proteins Expression and BRAF V600E Mutation in a Subset of Early- and Late-onset Colorectal Carcinoma Patients in Mexico

Luévano-González, Arturo; Guzman, Arturo Quintanilla; Rodríguez, Juan; Ortíz-López, Rocío; Rojas-Martínez, Augusto; González-Guerrero, Juan Francisco; Gutiérrez, Juan Pablo Flores

doi:10.1016/j.arcmed.2011.09.008

Cited by 8 publications

(1 citation statement)

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“…Moderately differentiated adenocarcinoma is the most general histology (≥ 80%) displayed by patients with CRC; this histology variant accounted for most cases in YOCRC and AOCRC ( 45 ). In addition, patients with YOCRC seem to have a stronger predisposition to present with mucinous, signet ring carcinoma and poorly differentiated tumours than AOCRC ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

The Clinicopathological Characteristics of Young-Onset Versus Adult-Onset Colorectal Cancer: A Tertiary Hospital-Based Study

Isah Tsamiya,

Mohd Nafi,

Che Jalil

et al. 2024

MJMS

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Background: The prevalence of colorectal cancer (CRC) among young individuals is rising worldwide, especially in Malaysia. Investigations are currently employed to distinguish the features of young-onset CRC (YOCRC) from adult-onset CRC (AOCRC). This study aimed to compare the characteristics of patients with YOCRC and AOCRC diagnosed at Hospital Universiti Sains Malaysia (HUSM). Methods: This was a retrospective study of CRC cases from January 2013 to December 2021. The details of YOCRC (< 50 years old) and AOCRC (≥ 50 years old) patients were retrieved from the laboratory system and medical records. The Pearson’s chi-square test, Fisher’s exact test and multiple logistic regression were used to compare the AOCRC and YOCRC cases. Statistical significance was defined at a P-value of ≤ 0.05. Results: The AOCRC (254/319, 79.6%) was more prevalent than YOCRC (65/319, 20.4%), with a predominance of males (53.9%) and Malay sub-population (90.2%). AOCRC and YOCRC shared similarities in left-sided location, high occurrence of adenocarcinoma with moderately differentiated histology and advanced stage of diagnosis. More patients with YOCRC (23.1%) had a family history of cancer than patients with AOCRC. YOCRC also differed from AOCRC by having more specific histological subtypes, such as mucinous adenocarcinoma (15.4%) and signet ring carcinoma (6.2%). In addition, patients with YOCRC commonly presented with a low density of tumour-infiltrating lymphocytes (TILs) (60%). Multiple logistic regression showed a family history of CRC (adjusted odds ratio [AOR] = 3.75, P = 0.003) and histological type (AOR = 15.21, P < 0.001) are more likely to cause YOCRC than diabetes (AOR = 0.06, P < 0.001) and hypertension (AOR = 0.14, P < 0.001) comorbidities, which are associated with AOCRC. Conclusion: Our descriptive study presented the epidemiological and histopathological characteristics of AOCRC and YOCRC in HUSM, providing current information on distinguishing features between the groups.

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Section: Discussionmentioning

confidence: 99%