Analysis of clinicopathologic correlations in Iranian patients with lupus nephritis

Abstract

We found that both histopathologic classification (ISN/RPS criteria) and histopathologic grading (US National Institutes of Health activity and chronicity indices) correlate to some clinical manifestations of LN. Considering these correlations may help to determine the patients' clinicopathologic status, prognosis and the need to immediate treatment. Nevertheless, it is necessary to clarify the accuracy of these findings in larger-scale prospective studies.

Explanatory histological findings for urinary protein and serum creatinine levels at renal biopsy in lupus nephritis: A cross-sectional study

“…SCr level was the only representative of glomerular sclerosis in our study. This finding is supported by previous studies showing that SCr level mainly reflects chronicity in LN [12,22] and is correlated with the renal interstitial lesion, sclerotic glomeruli, and tubular atrophy [23,24]. Although SCr level is a promising biomarker for renal prognosis in patients with LN, it is only related to the chronic lesions;…”

“…Some previous reports showed that the urinary protein level was related to activity index [20,21], while another report showed that proteinuria correlated neither with activity index nor with chronicity index [22]. Regarding detailed histological findings, one report showed that proteinuria was correlated with the hyaline deposit [12].…”

“…Proteinuria and serum creatinine (SCr) have been considered promising predictors for renal survival in patients with LN [5][6][7][8]; therefore, the primary outcome of most clinical studies for LN is defined by urinary protein and SCr levels [9,10]. It has previously been shown that chronic lesions in LN, such as chronic index, glomerular sclerosis, and interstitial fibrosis, are related to a poor renal outcome [11,12]. Estimated glomerular filtration rate (eGFR) is calculated using SCr level, and eGFR and proteinuria are biomarkers for classification of chronic kidney disease [13].…”

New perspectives and insights to Asian systemic lupus erythematosus: renal disease, genetic predisposition and disease activity

“…Asian lupus nephritis patients from the middle east and south Asian countries, including the subcontinent, need to be studied as they may require different treatment options and guidelines due to differences in disease presentation and progression. Strong conclusions cannot be drawn from the two papers on lupus nephritis from Iran in this issue, due in part to small sample sizes and the retrospective nature of their studies; however, high prevalence of renal failure in both the cohorts are noteworthy.…”

Clinicopathological Correlation in Asian Patients with Biopsy-Proven Lupus Nephritis

“…It has been generally agreed upon that renal morphological lesions and some clinical and laboratory features are correlated. Several studies are available on the clinicopathological correlation in LN subjects mainly from developed countries [ 6 , 7 ]. However, very few publications are currently available concerning the demographic, clinical, and pathological features of LN and their correlations in Thailand [ 8 ].…”