Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients’ Motor Function

Xie, Liang; Li, Mei

doi:10.1155/2022/5104121

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…The results of multicenter randomized controlled trials (RCT) showed that OA patients treated with shaoyang xibi decoction had lower Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and less adverse events than those treated with meloxicam alone ( 59 ). Another RCT showed that clearing heat and dispelling paralysis soup can better improve motor ability, and reduce the development of inflammation in the organism, with high safety and effectiveness compared with loxoprofen sodium dispersible tablets ( 60 ). A pooled analysis showed that duhuo jisheng decoction can reduce the pain and WOMAC scores in the treatment of Knee OA ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis

Liao

Yu²,

Chen³

et al. 2023

Front. Immunol.

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BackgroundAutophagy in osteoarthritis (OA) has become an active area of research with substantial value and potential. Nevertheless, few bibliometric studies have systematically analyzed the available research in the field. The main goal of this study was to map the available literature on the role of autophagy in OA and identify global research hotspots and trends.MethodsThe Web of Science Core Collection and Scopus databases were interrogated for studies of autophagy in OA published between 2004 and 2022. Microsoft Excel, VOSviewer and CiteSpace software were used to analyze and visualize the number of publications and associated citations, and reveal global research hotspots and trends in the autophagy in OA field.Results732 outputs published by 329 institutions from 55 countries/regions were included in this study. From 2004 to 2022, the number of publications increased. China produced the most publications (n=456), prior to the USA (n=115), South Korea (n=33), and Japan (n=27). Scripps Research Institute (n=26) was the most productive institution. Martin Lotz (n=30) was the highest output author, while Caramés B (n=302) was the highest output author. Osteoarthritis and Cartilage was the most prolific and most co-cited journal. Currently, the autophagy in OA research hotspots include chondrocyte, transforming growth factor beta 1 (TGF-β1), inflammatory response, stress, and mitophagy. The emerging research trends in this field are AMPK, macrophage, senescence, apoptosis, tougu xiaotong capsule (TXC), green tea extract, rapamycin, and dexamethasone. Novel drugs targeting specific molecule such as TGF-β and AMPK have shown therapeutic potential but are still in the preclinical stage of development.ConclusionsResearch on the role of autophagy in OA is flourishing. Martin Lotz, Beatriz Caramés, and Osteoarthritis and Cartilage have made outstanding contributions to the field. Prior studies of OA autophagy mainly focused on mechanisms underlying OA and autophagy, including AMPK, macrophages, TGF-β1, inflammatory response, stress, and mitophagy. Emerging research trends, however, are centered around the relationship between autophagy, apoptosis, and senescence, as well as drug candidates such as TXC and green tea extract. The development of new targeted drugs that enhance or restore autophagic activity is a promising strategy for the treatment of OA.

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Section: Discussionmentioning

confidence: 99%

Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis

Liao

Yu²,

Chen³

et al. 2023

Front. Immunol.

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“…Qinghe dispel paralysis decoction is a common TCM formula for removing qi, dispelling wind and dampness, and strengthening spleen 101 . A study combining Western medicine with Qinghe dispel paralysis decoction to treat patients with KOA found that it can better relieve joint pain, improve motor ability, and reduce the development of inflammation in the organism, with high safety and effectiveness 102 . Paeonia lactiflora and Commiphora myrrha have been used in traditional medicines for treating joint diseases.…”

Section: Animal Model Of Koa With Intervention Of Chinese Herbal Comp...mentioning

confidence: 99%

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Song,

Liu,

Chen

et al. 2024

Anim Models and Exp Med

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BackgroundKnee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves complex mechanisms that result in the same outcome. Consequently, researchers are interested in studying KOA and require appropriate animal models for basic research. Chinese herbal compounds, which consist of multiple herbs with diverse pharmacological properties, possess characteristics such as multicomponent, multipathway, and multitarget effects. The potential benefits in the treatment of KOA continue to attract attention.PurposeThis study aims to provide a comprehensive overview of the advantages, limitations, and specific considerations in selecting different species and methods for KOA animal models. This will help researchers make informed decisions when choosing an animal model.MethodsOnline academic databases (e.g., PubMed, Google Scholar, Web of Science, and CNKI) were searched using the search terms “knee osteoarthritis,” “animal models,” “traditional Chinese medicine,” and their combinations, primarily including KOA studies published from 2010 to 2023.ResultsBased on literature retrieval, this review provides a comprehensive overview of the methods of establishing KOA animal models; introduces the current status of advantages and disadvantages of various animal models, including mice, rats, rabbits, dogs, and sheep/goats; and presents the current status of methods used to establish KOA animal models.ConclusionThis study provides a review of the animal models used in recent KOA research, discusses the common modeling methods, and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

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“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

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confidence: 99%

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confidence: 99%

Retracted: Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients’ Motor Function

Methods in Medicine

2023

Computational and Mathematical Methods in Medicine

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Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients’ Motor Function

Cited by 4 publications

References 27 publications

Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis

Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis

Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine

Retracted: Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients’ Motor Function

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