Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis

Abstract

BackgroundAutophagy in osteoarthritis (OA) has become an active area of research with substantial value and potential. Nevertheless, few bibliometric studies have systematically analyzed the available research in the field. The main goal of this study was to map the available literature on the role of autophagy in OA and identify global research hotspots and trends.MethodsThe Web of Science Core Collection and Scopus databases were interrogated for studies of autophagy in OA published between 2004 and 2022. Microsoft Excel, VOSviewer and CiteSpace software were used to analyze and visualize the number of publications and associated citations, and reveal global research hotspots and trends in the autophagy in OA field.Results732 outputs published by 329 institutions from 55 countries/regions were included in this study. From 2004 to 2022, the number of publications increased. China produced the most publications (n=456), prior to the USA (n=115), South Korea (n=33), and Japan (n=27). Scripps Research Institute (n=26) was the most productive institution. Martin Lotz (n=30) was the highest output author, while Caramés B (n=302) was the highest output author. Osteoarthritis and Cartilage was the most prolific and most co-cited journal. Currently, the autophagy in OA research hotspots include chondrocyte, transforming growth factor beta 1 (TGF-β1), inflammatory response, stress, and mitophagy. The emerging research trends in this field are AMPK, macrophage, senescence, apoptosis, tougu xiaotong capsule (TXC), green tea extract, rapamycin, and dexamethasone. Novel drugs targeting specific molecule such as TGF-β and AMPK have shown therapeutic potential but are still in the preclinical stage of development.ConclusionsResearch on the role of autophagy in OA is flourishing. Martin Lotz, Beatriz Caramés, and Osteoarthritis and Cartilage have made outstanding contributions to the field. Prior studies of OA autophagy mainly focused on mechanisms underlying OA and autophagy, including AMPK, macrophages, TGF-β1, inflammatory response, stress, and mitophagy. Emerging research trends, however, are centered around the relationship between autophagy, apoptosis, and senescence, as well as drug candidates such as TXC and green tea extract. The development of new targeted drugs that enhance or restore autophagic activity is a promising strategy for the treatment of OA.

Autophagy in Osteoarthritis: A Double-Edged Sword in Cartilage Aging and Mechanical Stress Response: A Systematic Review

“…The role of autophagy in OA-associated cartilage deterioration has been discussed in prior review articles [51][52][53]; however, the purpose of this study was to comprehensively consolidate recent advancements in this field, while also offering distinct perspectives and valuable insights. In the present systematic review, we assessed the evidence from in vitro studies investigating the effects of autophagy on human chondrocytes.…”

Global research trends and hot spots on autophagy and kidney diseases: a bibliometric analysis from 2000 to 2022

“…Bibliometric tools including R package “bibliometrix”, VOSviewer, CiteSpace are commonly used for visualizing the results of bibliographic analysis ( Wu et al, 2022 ; Liao et al, 2023 ). And we selected appropriate software to analyze different aspects of our research results for optimal presentation.…”

“…Additionally, to identify the basis, frontiers, and highlights of the field, we will utilize author keywords and conduct keyword co-occurrence analyses. To our knowledge, bibliometric research has been conducted on the relationship between autophagy and cardiovascular diseases, osteoarthritis, cancer, and lung diseases ( Zhou et al, 2021 ; Lin et al, 2022 ; Xu et al, 2022 ; Liao et al, 2023 ), but it has not been applied to the study of autophagy and kidney diseases. Therefore, our purpose is to uncover the existing research status and future directions of autophagy in kidney diseases through bibliometric analysis, identifying major contributors, institutions, countries, and the current research focus, to provide a reference for future studies on autophagy in kidney diseases.…”

Cancer Immunotherapy and Medical Imaging Research Trends from 2003 to 2023: A Bibliometric Analysis

“…This database offers abundant citation information, which aids in tracking the citation of literature and assessing the impact of research. 25,26 To mitigate any potential bias introduced by database updates, we conducted literature searches and data export using the WoSCC on February 28th, 2024. The search terms were #1TS= (Immunotherapy) OR (immunotherapeutic) OR (immunotherapies) OR (immunization therapy) OR (immune therapy) OR (immunity treatment); #2TS= (cancer) OR (carcinoma) OR (tumor oncology) OR (neoplasms) OR (carcinomatosis) OR (tumor); #3TS= (medical imaging) OR (diagnostic imaging) OR (radiography).…”