Analysis of chronic lymphoid leukaemias according to FAB

Oertel, Joachim; Kastner, Michael; Bai, Aiping; Kleiner, S.; Huhn, D.

doi:10.1016/0145-2126(92)90037-8

Cited by 8 publications

(6 citation statements)

References 28 publications

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“…We found a typical morphological picture of marginal zone cells with moderate or strong irregularity of the nuclear outlines, a large nucleus, and small clumps in the finely stranded chromatin. This is in agreement with a leukaemic case which we described 9 years ago (Oertel et al 1992). The expression of CD5 and CD23 do not help to diagnose the marginal zone lymphoma cells.…”

Section: Discussionsupporting

confidence: 90%

“…The nodal marginal zone lymphoma (or monocytoid B-cell lymphoma) has a high frequency of disseminated disease at diagnosis (Sheibani et al 1988;Fisher et al 1995;Nathwani et al 1999). Peripheral blood involvement seems fairly uncommon and has been reported only in a few cases (Traweek et al 1989;Cogliatti et al 1990;Oertel et al 1992). We analyse the morphology and the immunotype of leukaemic marginal zone lymphoma in 11 patients and describe the differences from leukaemic mantle cell lymphoma, follicular lymphoma and diffuse large B-cell lymphoma, which is a challenge for the haematologist.…”

Section: Introductionmentioning

confidence: 96%

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Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression

Oertel

Kingreen

Busemann

et al. 2002

Journal of Cancer Research and Clinical Oncology

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The morphologic analysis of lymphoma cells in cytocentrifuge preparations of mononuclear leukocytes in combination with immunocytochemical investigation allows the detection of mantle cells, centrocytes of follicular lymphoma, marginal zone cells, and cells of the diffuse large B-cell lymphoma in peripheral blood. The positivity of cyclin D1 protein improves the differentiation of mantle cells from other lymphoma cells.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 96%

Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression

Oertel

Kingreen

Busemann

et al. 2002

Journal of Cancer Research and Clinical Oncology

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“…Although the prognostic significance of clinical staging according to Rai and Binet has been well established, the validity of subtyping CLL in typical and atypical cases, as proposed by the FAB group (Bennett et al, 1989), is less well investigated. Only few studies about feasibility (Oertel et al, 1992) and prognostic significance (Vallespí, 1991) have been reported. We found that trisomy 12, the most frequent chromosomal abnormality in CLL, is rarely found in typical CLL but frequently occurs in atypical CLL (Criel et al, 1994); the present study confirms this finding.…”

Section: Discussionmentioning

confidence: 99%

“…Only few studies about feasibility (Oertel et al, 1992) and prognostic significance (Vallespí, 1991) have been reported. We found that trisomy 12, the most frequent chromosomal abnormality in CLL, is rarely found in typical CLL but frequently occurs in atypical CLL (Criel et al, 1994); the present study confirms this finding.…”

Section: Discussionmentioning

confidence: 99%

Further characterization of morphologically defined typical and atypical CLL: a clinical, immunophenotypic, cytogenetic and prognostic study on 390 cases

et al. 1997

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Summary.We analysed a group of 390 patients, diagnosed with chronic lymphocytic leukaemia (CLL). Cases were subclassified as morphologically typical and atypical CLL according to the criteria of the FAB proposal. Typical CLL cases were mostly diagnosed at a low-risk stage (Binet A/Rai 0), required no immediate treatment and expected a long survival; atypical CLL cases mostly presented at a more advanced risk stage (Binet B/Rai I-II), usually required immediate treatment and their survival was shorter. Moreover, clinical staging was of prognostic significance in typical but not in atypical cases.In typical CLL, del(11q) was the most common chromosomal abnormality (21%) whereas in atypical CLL trisomy 12 was found in about 65% of the cases documented with an abnormal karyotype. Although chromosomal abnormalities were associated with a poor survival in typical CLL, they are of no prognostic significance in atypical CLL.Based on these data, we conclude that subtyping CLL by morphology enables the identification of two groups of cases, each characterized by a specific clinical presentation, different cytogenetic abnormalities and prognostic parameters. We speculate that these two groups may represent two related, but different, diseases with different prognostic parameters and a different survival.

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“…The CDllc/CD18 complex is found in tissue macrophages and monocytes, and is necessary for cell-cell and cell-surface adhesion. 27 According to the literature, CDllc may occasionally be expressed in SLL 9 but is typically absent in MCL. 5 In our study, CDllc was frequently expressed in both SLL and SLLP but was absent in MCL.…”

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confidence: 99%

Flow Cytometric and Immunohistochemical Analysis of Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, and Plasmacytoid Small Lymphocytic Lymphoma

et al. 1998

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Small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL), and SLL plasmacytoid (SLLP) are malignant neoplasms of small B cells that may have overlapping cytologic features. Entities such as SLL with irregular nuclear contours may pose additional diagnostic difficulties. We investigated the utility of flowHistologically, small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL), and SLL plasmacytoid (SLLP) are lymphomas composed of small lymphocytes. Distinguishing these lymphomas from each other on histologic grounds can be difficult. Particularly when SLL is composed of lymphocytes with irregular nuclear contours, it may be difficult to distinguish SLL from MCL. Yet this distinction is important clinically inasmuch as MCL has a shorter median survival than SLL or SLLP, and it is treated more aggressively than SLL or SLLP.1 Furthermore, it is important to distinguish SLL from SLLP because SLLP is often associated with macroglobulinemia and its hyperviscosity complications. 2Immunophenotypic characterization of these disorders by flow cytometry and immunohistochemistry has been shown to be a useful adjunct to their histologic classification. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] CD23 is a B-cell activation antigen that functions in IgEmediated presentation to T cells 17 and prevents apoptosis of B cells in germinal centers. 18 Recently, assessment of CD23 expression by flow cytometry has been found to be useful in distinguishing SLL from MCL 56 and discriminating SLL from SLLP. 6 By both flow cytometry and immunohistochemistry, CD23 has tended to be present in SLL, absent in MCL) 4,7,10,1U3,19 a n d a b s e n t i n SLLP. 478 ' 13 However, there have been reports of CD23 expression in a majority of SLLP" or MCL cases. 20 The use of anti-CD23 by immunohistochemistry has been successful with frozen section material. Recently, two published studies reported success with anti-CD23 in paraffin-embedded material. 7,21Our objectives in this study were 3-fold: investigate the utility of immunohistochemical detection of CD23 expression in paraffin-embedded material to aid in the distinction of SLL from MCL and SLL from SLLP; investigate whether a battery of other immunophenotypic markers can help in making these distinctions by immunohistochemical and flow 5 8 2

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Analysis of chronic lymphoid leukaemias according to FAB

Cited by 8 publications

References 28 publications

Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression

Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression

Further characterization of morphologically defined typical and atypical CLL: a clinical, immunophenotypic, cytogenetic and prognostic study on 390 cases

Flow Cytometric and Immunohistochemical Analysis of Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, and Plasmacytoid Small Lymphocytic Lymphoma

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