Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression

Oertel, Joachim; Kingreen, D.; Busemann, Christoph; Stein, Harald; Dörken, Bernd

doi:10.1007/s00432-001-0311-4

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…Limiting the study to CD5 þ cases allowed one to exclude all potential confusion with hairy cell leukemia, and limiting potential discussion of marginal zone lymphomas to very rare CD5 þ cases whose existence remains controversial. 43,44 No patient was diagnosed as typical CLL when the criteria of having both typical morphology and an RMH score above 3 were applied. RMH score was 2 in 27 patients and below in 18 patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders

et al. 2004

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Nodal mantle cell lymphoma (MCL) is a well-defined entity, but non-nodal leukemic cyclin D1 positive lymphoproliferative disorders have been reported and their relationship with MCL remains controversial and their prognosis heterogeneous. We prospectively studied the expression of cyclin D1 in CD5 positive leukemic B lymphoproliferative disorders at diagnosis and identified 65 cases overexpressing cyclin D1. We did not distinguish any clinical or biological criteria allowing one to identify a non-MCL group. Multivariate analysis identified age, anemia and p27kip1 expression as independent prognostic factors of survival. By univariate analysis, p27kip1 high expression proved to be the strongest predictor of prolonged survival. The median survival of p27 low expressors was 30 months, while it was not reached for p27 high expressors. A high level of p27 expression was often found associated with the absence of nodal involvement and the presence of somatic mutations, but neither of them was restricted to the p27 high expression group. In conclusion, we hypothesize that MCL and these cyclin D1 positive leukemic lymphoproliferative disorders represent a continuous spectrum of diseases. Determination of p27 expression level appears as a routine applicable test allowing identification of a subset of patients who could be considered for different therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders

et al. 2004

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“…(222)(223)(224). Cyclin D1 is overexpressed in B-cell malignancies (e.g., mantle cell lymphoma and some cases of prolymphocytic leukaemia, plasma cell leukaemia, splenic lymphoma with villous lymphocytes, chronic lymphocytic leukaemia, and multiple myeloma), invasive breast cancer, and other malignancies (225)(226)(227). In the hematopathology laboratory, cyclin D1 detection is mainly used in the diagnosis of mantle cell lymphoma (MCL), that results from chromosomal translocation t(11; 14)(q13; q32).…”

Section: Antigens Characteristic Of B Lymphocytesmentioning

confidence: 99%

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy

Riley

Williams

Ross

et al. 2009

Clinical Laboratory Analysis

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Bone marrow examination has become increasingly important for the diagnosis and treatment of hematologic and other illnesses. Morphologic evaluation of the bone marrow aspirate and biopsy has recently been supplemented by increasingly sophisticated ancillary assays, including immunocytochemistry, cytogenetic analysis, flow cytometry, and molecular assays. With our rapidly expanding knowledge of the clinical and biologic diversity of leukemia and other hematologic neoplasms, and an increasing variety of therapeutic options, the bone marrow examination has became more critical for therapeutic monitoring and planning optimal therapy. Sensitive molecular techniques, in vitro drug sensitivity testing, and a number of other special assays are available to provide valuable data to assist these endeavors. Fortunately, improvements in bone marrow aspirate and needle technology has made the procurement of adequate specimens more reliable and efficient, while the use of conscious sedation has improved patient comfort. The procurement of bone marrow specimens was reviewed in the first part of this series. This paper specifically addresses the diagnostic interpretation of bone marrow specimens and the use of ancillary techniques.

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2021

Flow Cytometry of Hematological Malignancies

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Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression

Cited by 7 publications

References 24 publications

Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders

Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders

Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy

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