Analysis of Changes in Serum Levels and Gene Expression Profiles of Novel Adipocytokines (Omentin, Vaspin, Irisin and Visfatin) and Their Correlation with Serum C-reactive Protein Levels in Women Diagnosed with Endometriosis

Kaya‐Sezginer, Ecem; Kirlangic, Omer Faruk; Tanrıverdi, Merve Didem Eşkin; Topçu, Hasan Onur; Gür, Serap

doi:10.4274/tjps.galenos.2021.52284

Cited by 7 publications

(6 citation statements)

References 42 publications

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“…These findings contrast with other studies, which indicated lower serum irisin levels compared to the control in inflammation-related diseases [71,75]. The authors speculated that the increase in irisin might be an adaptive response to compensate for the increased inflammation in endometriosis [74].…”

Section: Irisin and Endometriosiscontrasting

confidence: 70%

“…It affects approximately 5-10% of women of reproductive age, and reduces women's quality of life, due to dysmenorrhea, chronic pelvic pain, irregular uterine bleeding, and infertility [73]. To our knowledge, only one study has been conducted to investigate irisin levels in patients with endometriosis [74]. Kaya Sezginer et al [74] found that serum irisin levels were increased in endometriosis patients compared to controls, which appeared to correlate with BMI and C-reactive protein.…”

Section: Irisin and Endometriosismentioning

confidence: 99%

“…To our knowledge, only one study has been conducted to investigate irisin levels in patients with endometriosis [74]. Kaya Sezginer et al [74] found that serum irisin levels were increased in endometriosis patients compared to controls, which appeared to correlate with BMI and C-reactive protein. These findings contrast with other studies, which indicated lower serum irisin levels compared to the control in inflammation-related diseases [71,75].…”

Section: Irisin and Endometriosismentioning

confidence: 99%

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The Role of Irisin throughout Women’s Life Span

Barbagallo,

Cannarella,

Garofalo

et al. 2023

Biomedicines

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Since its discovery, much attention has been drawn to irisin’s potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puberty and menopause) and pathological (polycystic ovary syndrome (PCOS), functional hypothalamic amenorrhea (FHA), endometriosis, and gestational diabetes) conditions that can affect women throughout their entire lives. Irisin appears to be an important factor for the hypothalamic–pituitary–gonadal axis activation, and appears to play a role in the timing of puberty onset. Serum irisin levels have been proposed as a biomarker for predicting the future development of gestational diabetes (GDM). Its role in PCOS is still controversial, although an “irisin resistance” mechanism has been hypothesized. In addition to its impact on metabolism, irisin also appears to influence bone health. Irisin levels are inversely correlated with the prevalence of fractures in postmenopausal women. Similar mechanisms have also been postulated in young women with FHA. In clinical settings, further controlled, prospective and randomized clinical trials are needed to investigate the casual relationship between irisin levels and the conditions described and, in turn, to establish the role of irisin as a prognostic/diagnostic biomarker or a therapeutic target.

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Section: Irisin and Endometriosiscontrasting

confidence: 70%

Section: Irisin and Endometriosismentioning

confidence: 99%

Section: Irisin and Endometriosismentioning

confidence: 99%

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The Role of Irisin throughout Women’s Life Span

Barbagallo,

Cannarella,

Garofalo

et al. 2023

Biomedicines

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“…The appetite is associated with a decrease in neuropeptide Y secretion and increases in energy expenditure. In the liver, it augments insulin half-life and promotes augmented insulin signaling [ 115 , 116 , 117 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. Organokines can produce beneficial or harmful effects in this condition. Among RA patients, organokines have been associated with increased inflammation and cartilage degradation due to augmented cytokines and metalloproteinases production, respectively. This study aimed to perform a review to investigate the role of adipokines, osteokines, myokines, and hepatokines on RA progression. PubMed, Embase, Google Scholar, and Cochrane were searched, and 18 studies were selected, comprising more than 17,000 RA patients. Changes in the pattern of organokines secretion were identified, and these could directly or indirectly contribute to aggravating RA, promoting articular alterations, and predicting the disease activity. In addition, organokines have been implicated in higher radiographic damage, immune dysregulation, and angiogenesis. These can also act as RA potent regulators of cells proliferation, differentiation, and apoptosis, controlling osteoclasts, chondrocytes, and fibroblasts as well as immune cells chemotaxis to RA sites. Although much is already known, much more is still unknown, principally about the roles of organokines in the occurrence of RA extra-articular manifestations.

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“…This increase in vascular production could be a compensatory response to the influence of unknown proteases found in fat and other tissues that inhibit insulin action. As a result, up-regulation of vascular expression may be used as a defense mechanism against insulin resistance [4].It have been discovered that adults have vascularized visceral and subcutaneous adipose tissue, with depot-specific regulation supposed to be controlled by body fat level or insulin sensitivity [5].…”

Section: Introductionmentioning

confidence: 99%

Relationship the Variation of Serum Vaspin and Some Biochemical Parameters Associated with Gender and BMI of Type2 Diabetic Patients

Abdalelah Saleem

2024

Acad. Sci. J.

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Diabetes mellitus is a chronic disorder categorized by rise blood glucose with a disturbance in the use of carbohydrates, fats and proteins resulting from a deficiency in the secretion of the insulin or the action of insulin or both. The current study aimed to estimation of Vaspin and some biochemical parameters included insulin, fasting blood glucose(FBG), HbA1c, urea, creatinine, Triglyceride(TG), Total Cholesterol(TC), High-density lipoprotein (HDL), low density lipoprotein (LDL) and Very low density lipoprotein (VLDL)in blood of type2 diabetic patients, and determining the change of the ratio in patients comparing with healthy people.The serum vaspin level in patients group was significantly lower than that of the healthy subjects (p<0.05). The serum insulin levels in patients were higher than of healthy subjects but without significant differences (p>0.05). There were a significant difference of serum FBG, HbA1c and urea levels in patients compared to controls (p<0.05), while creatinine level was increased non significantly (p>0.05). The levels of TC, TG, LDL and VLDL were elevated significantly in patients when compared with controls (p<0.05), while HDL was diminished non significantly in patients compared to controls. There was no significant links between serum vaspin and insulin concentrations with FBG, HbA1C, CRP, urea, creatinine, TC, TG, LDL, HDL, and VLDL levels. Vaspin had lowest area under curve (AUC 393 .) and sensitivity ( 68.3 ) in ROC curve.

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Analysis of Changes in Serum Levels and Gene Expression Profiles of Novel Adipocytokines (Omentin, Vaspin, Irisin and Visfatin) and Their Correlation with Serum C-reactive Protein Levels in Women Diagnosed with Endometriosis

Cited by 7 publications

References 42 publications

The Role of Irisin throughout Women’s Life Span

The Role of Irisin throughout Women’s Life Span

Organokines in Rheumatoid Arthritis: A Critical Review

Relationship the Variation of Serum Vaspin and Some Biochemical Parameters Associated with Gender and BMI of Type2 Diabetic Patients

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