Analysis of BoLA class II microsatellites in cattle infested with Boophilus microplus ticks: class II is probably associated with susceptibility

Acosta-Rodríguez, Rebeca; Alonso-Morales, Rogelio Alejandro; Balladares, Sandra; Flores-Aguilar, Hilario; García-Vázquez, Zeferino; Gorodezky, Clara

doi:10.1016/j.vetpar.2004.10.007

Cited by 40 publications

(25 citation statements)

References 26 publications

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“…Acosta-Rodriguez et al . [39] showed that some MHC BoLA class II alleles determine, at least partly, the susceptibility to tick infestation. BoLA class I alleles w6.1 and w7 have been related to tick protection.…”

Section: Resultsmentioning

confidence: 99%

Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus × Bos indicus)

Machado¹,

Azevedo²,

Teodoro³

et al. 2010

BMC Genomics

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BackgroundIn tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross.ResultsThrough a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23.ConclusionsThe experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.

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Section: Resultsmentioning

confidence: 99%

Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus × Bos indicus)

Machado¹,

Azevedo²,

Teodoro³

et al. 2010

BMC Genomics

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“…Association between, bovine major histocompatibility complex (MHC) (BoLA) class II alleles and tick resistance have been reported (Acosta-Rodríguez et al 2005). Martinez et al (2006) found an association between BoLA alleles and low tick number for alleles DRB 3.2 *18, *20 and *27 and suggested that BoLA-DRB 3.2 alleles could be used to help in the selection of animals resistant to tick infestation.…”

Section: Gene and Markers Associated With Tick Resistancementioning

confidence: 99%

Breeding strategies for tick resistance in tropical cattle: a sustainable approach for tick control

2013

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About 80 % of world cattle population is under the risk of ticks and tick borne diseases (TTBDs). Losses caused by bovine tick burdens in tropical countries have a tremendous economic impact on production systems. Chemical control of disease has been found to be ineffective and also involving large cost. To reduce our reliance on these chemical products, it is necessary to embark on programs that include habitat management, genetic selection of hosts, and development of a strain capable of inducing host resistance to ticks. Selection for disease resistance provide alternate method for sustainable control of TTBDs. Domestic livestock manifests tick-resistance by skin thickness, coat type, coat color, hair density and skin secretions etc. Zebu cattle have, on average, greater tick resistance than either European cattle or African cattle. Heritability for tick burden in cattle has been shown to range about 0.30, which is sufficient to result in the success of some programs of selection for tick resistance in cattle. To select animals at younger age, to reduce generation interval and to increase genetic gain, marker assisted selection is an important tool. There are also various MHC molecules which are associated with resistance to TTBDs.

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“…Previous genetic studies found that the bovine leucocyte antigens (BoLA) were associated with tick burden [13,14] and these associations have more recently been confirmed using DNA polymorphisms [15-17], but the same allele has not always been associated with reduced tick numbers limiting the use of those markers in different populations. Whole genome scans using DNA microsatellites in linkage analyses have identified a small number of QTL associations [18,19] and a low density genome wide association study (GWAS) identified single nucleotide polymorphisms (SNP) associated with tick burden in several regions of the genome [20].…”

Section: Introductionmentioning

confidence: 99%

Haplotypes that include the integrin alpha 11 gene are associated with tick burden in cattle

et al. 2010

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BackgroundInfestations on cattle by the ectoparasite Boophilus (Rhipicephalus) microplus (cattle tick) impact negatively on animal production systems. Host resistance to tick infestation has a low to moderate heritability in the range 0.13 - 0.64 in Australia. Previous studies identified a QTL on bovine chromosome 10 (BTA10) linked to tick burden in cattle.ResultsTo confirm these associations, we collected genotypes of 17 SNP from BTA10, including three obtained by sequencing part of the ITGA11 (Integrin alpha 11) gene. Initially, we genotyped 1,055 dairy cattle for the 17 SNP, and then genotyped 557 Brahman and 216 Tropical Composite beef cattle for 11 of the 17 SNP. In total, 7 of the SNP were significantly (P < 0.05) associated with tick burden tested in any of the samples. One SNP, ss161109814, was significantly (P < 0.05) associated with tick burden in both the taurine and the Brahman sample, but the favourable allele was different. Haplotypes for three and for 10 SNP were more significantly (P < 0.001) associated with tick burden than SNP analysed individually. Some of the common haplotypes with the largest sample sizes explained between 1.3% and 1.5% of the residual variance in tick burden.ConclusionsThese analyses confirm the location of a QTL affecting tick burden on BTA10 and position it close to the ITGA11 gene. The presence of a significant association in such widely divergent animals suggests that further SNP discovery in this region to detect causal mutations would be warranted.

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Analysis of BoLA class II microsatellites in cattle infested with Boophilus microplus ticks: class II is probably associated with susceptibility

Cited by 40 publications

References 26 publications

Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus × Bos indicus)

Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus × Bos indicus)

Breeding strategies for tick resistance in tropical cattle: a sustainable approach for tick control

Haplotypes that include the integrin alpha 11 gene are associated with tick burden in cattle

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