Analysis of blood from Zika virus-infected fetuses: a prospective case series

Schaub, Bruno; Vouga, Manon; Najioullah, Fatiha; Gueneret, M.; Monthieux, Alice; Harte, Caroline; Müller, Françoise; Jolivet, E.; Adenet, C.; Dreux, Sophie; Leparc-Goffart, Isabelle; Césaire, Raymond; Voluménie, Jean-Luc; Baud, David

doi:10.1016/s1473-3099(17)30102-0

Cited by 88 publications

(86 citation statements)

References 35 publications

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“…Mild anemia, cholestasis, and transient hepatitis have been found in fetuses and newborns infected by ZIKV …”

Section: Congenital Zikv Syndromementioning

confidence: 99%

“…The sensitivity of amniocentesis remains unknown because of the lack of knowledge about the evolution of viremia. Schaub et al showed that ZIKV RNA amplification could be transient in the amniotic fluid, fetal blood, and placenta . Thus, ZIKV may no longer be detectable after a prolonged time from the initial infection, since ZIKV secretion by the fetal kidney is probably transient, and RNA is less stable than DNA (ie, CMV).…”

Section: Management Of Exposed Pregnancies and Recommandationsmentioning

confidence: 99%

“…Schaub et al described the biological responses to ZIKV infection in fetal blood, such as transient anemia or increased liver enzyme levels . It is yet unknown whether these markers of infection or viral loads in fetal blood are prognostic factors, such as in congenital CMV infection …”

Section: Management Of Exposed Pregnancies and Recommandationsmentioning

confidence: 99%

“…Mild anemia, cholestasis, and transient hepatitis have been found in fetuses and newborns infected by ZIKV. 80,81 Neurologic impairments such as swallowing dysfunction, movement abnormalities, and epilepsy have been described in infants suffering from CZS as well as in infants asymptomatic at birth. 82 The predominant neurologic findings in young infants with suspected congenital ZIKV infection are extreme irritability, hyperreflexia, and hypertonia with spasticity, tremors, and extrapyramidal symptoms, hypotonia, or a combination of hyper-and hypotonia.…”

Section: Clinical Features Of Czs At Birthmentioning

confidence: 99%

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Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome

et al. 2019

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What is already known about the topic? The Zika virus (ZIKV) emergence and its consequences during pregnancy led to an increasing number of data about the maternal and fetal consequences of ZIKV infections. What does this study add? This review evaluates risks of maternal ZIKV infection, maternal‐fetal transmission, congenital Zika syndrome (CZS), other adverse perinatal outcomes, and long‐term sequelae among pregnancies exposed to ZIKV. This review also provides contemporary criteria and guidelines for the follow‐up of exposed fetuses, based on prenatal and postnatal features of CZS.

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“…Mild anemia, cholestasis, and transient hepatitis have been found in fetuses and newborns infected by ZIKV …”

Section: Congenital Zikv Syndromementioning

confidence: 99%

Section: Management Of Exposed Pregnancies and Recommandationsmentioning

confidence: 99%

Section: Management Of Exposed Pregnancies and Recommandationsmentioning

confidence: 99%

Section: Clinical Features Of Czs At Birthmentioning

confidence: 99%

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Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome

et al. 2019

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“…The latter has been reported before and was described as "pallor" (42). In addition, recent analyses of fetal blood samples from ZIKV-infected mothers also revealed anemia (43), warranting further investigation of the underlying mechanisms.…”

Section: Discussionmentioning

confidence: 60%

A Measles Virus-Based Vaccine Candidate Mediates Protection against Zika Virus in an Allogeneic Mouse Pregnancy Model

Nürnberger

Bodmer

Fiedler

et al. 2019

J Virol

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The impact of the Zika virus (ZIKV) epidemic highlights the need for vaccines that reduce or prevent infection and reliably prevent teratogenic complications. The live-attenuated measles virus (MV) vaccine strains are a promising vaccine platform, since they induce robust humoral and cellular immune responses against additional antigens and have an excellent safety record. To explore its potential to protect against ZIKV, we compared a recombinant Schwarz strain MV that encodes ZIKV prM and soluble E proteins (MV-Zika-sE) with a prototypic alum-adjuvanted whole inactivated ZIKV particle vaccine. Analysis of MV-Zika-sE-infected cells confirmed antigen expression, and the virus replicated with vaccine strain characteristics. Immunized IFNAR Ϫ/Ϫ -CD46Ge mice developed E protein-specific and neutralizing antibodies, and ZIKV E-specific cellular immune responses were observed by gamma interferon (IFN-␥) enzyme-linked immunospot (ELISpot) and in vitro T cell proliferation assays. To analyze protective efficacy, vaccinated female mice were challenged with ZIKV after allogeneic mating. In MV-Zika-sE-vaccinated mice, weight gain was similar to that in uninfected mice, while no plasma viremia was detectable in the majority of the animals. In contrast, infected control animals gained less weight and experienced about 100-fold higher viremia over at least 3 days. Moreover, vaccination with MV-Zika-sE reduced the ZIKV load in different organs and the placentas and prevented infection of the fetus. Consequently, no fetal growth retardation, anemia, or death due to ZIKV infection was seen in MV-Zika-sE-vaccinated dams. In contrast, the inactivated ZIKV vaccine had little to no effect in our studies. Therefore, the MV-derived ZIKV vaccine is a promising candidate for further preclinical and clinical development. IMPORTANCE Zika virus (ZIKV) is a mosquito-borne flavivirus that causes a variety of neurological complications, including congenital birth defects. Despite the urgent need, no ZIKV vaccine has yet been licensed. Recombinant vaccine strain-derived measles viruses (MV) constitute a promising vector platform to induce immunity against foreign pathogens by expressing antigens from additional transcription units while at the same time possessing a remarkable safety profile. This concept has already been validated against different pathogens, including at least 3 other flaviviruses, and our data show that vaccination with MV expressing soluble ZIKV E protein significantly diminishes infection and prevents fetal loss or damage in an allogeneic mouse pregnancy model. It can thus be regarded as a promising emergency vaccine candidate with the potential for inclusion in routine vaccination settings in areas of endemicity to prevent teratogenic effects of circulating ZIKV during pregnancy, comparable to standard rubella virus vaccination.

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