Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method

Bibi, Suriya; Nawaz, Rakhshanda; Nawaz, Md. Saddam; Shahid, Muhammad; Kiani, Sobia Qamar

doi:10.3923/jbs.2002.769.770

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Good recovery results were obtained, as shown in Table 2. The maximum plasma concentration of SCZ in healthy individuals has been reported to reach 16.2 μg/mL [36] to 24.8 μg/mL [37], with half-life values of 19.60 and 13.86 h, respectively, following the administration of 2 g of SCZ. This is equivalent to maximum plasma levels of 87 to 133 μM.…”

Section: Practical Analysismentioning

confidence: 99%

“…The data presented in Table 2 show that ZTO/TO MPs/GCE is a promising sensor for the analysis of SCZ in real samples, facilitating the analysis of its concentration as it decays from these maximum levels. The maximum plasma concentration of SCZ in healthy individuals has been reported to reach 16.2 µg/mL [36] to 24.8 µg/mL [37], with half-life values of 19.60 and 13.86 h, respectively, following the administration of 2 g of SCZ. This is equivalent to maximum plasma levels of 87 to 133 µM.…”

Section: Practical Analysismentioning

confidence: 99%

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Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

et al. 2021

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In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.

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Section: Practical Analysismentioning

confidence: 99%

Section: Practical Analysismentioning

confidence: 99%

Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

et al. 2021

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Bioavailability of two oral formulas of secnidazole in healthy volunteers

Montovani

Pinto

Santos

et al. 2009

Braz. J. Pharm. Sci.

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Secnidazole is an antimicrobial agent used primarily in the treatment of amoebiasis. For this bioequivalence study of secnidazole, twenty-eight healthy female volunteers were enrolled in a randomized crossover study. Each volunteer was given a single oral dose of secnidazole test preparation and then the reference preparation, or vice versa, with a wash out interval of two weeks. The plasma concentrations of secnidazole were determined by HPLC, and the samples were extracted with tert-butyl-methyl-ether: dicloromethane (60:40, v/v). Secnidazole and its parent compound metronidazole were separated on a C18 column with water:acetonitrile (85:15, v/v) as the mobile phase, and monitored at 310 nm. The ratio of mean C max , AUC 0−t and AUC 0−∞ values for the test and reference products were within the predetermined range established by ANVISA, demonstrating that the two formulations are bioequivalent in rate and extent of absorption. Uniterms:Oral formulas/bioequivalence study. Secnidazole/bioavailability. Antimicrobials/ bioavailability. Secnidazol é um agente antimicrobiano utilizado principalmente no tratamento da amebíase. Para este estudo de bioequivalência de secnidazol em voluntários saudáveis, foram incluídos vinte e oito voluntárias mulheres no estudo randomizado cruzado. Cada voluntária recebeu uma única dose oral de secnidazol do produto teste e referência para comparação, com um intervalo de wash-out de duas semanas. As concentrações plasmáticas de secnidazol foram determinados por CLAE, as amostras foram extraídas com terc -butil-metil-éter: dicloromethano (60:40, v/v). O secnidazol e seu padrão interno metronidazol foram separados em uma coluna (C18 ) com fase móvel água ultra-pura:acetonitrila (85:15, v/v) e monitorado em 310 nm. As razões entre as médias geométricas de C máx , ASC 0-t e ASC 0-∞ , encontraramse dentro do estabelecido pela ANVISA, demonstrando que as formulações são bioequivalentes quanto à taxa e extensão de absorção Unitermos: Formulações orais/estudo de bioequivalência. Secnidazol/biodisponibilidade. Antimicrobianos/biodisponibilidade.

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Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method

Cited by 2 publications

References 5 publications

Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

Bioavailability of two oral formulas of secnidazole in healthy volunteers

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