Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

Abstract

In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.

Synthesis of active-site rich molybdenum-doped manganese tungstate nanocubes for effective electrochemical sensing of the antiviral drug (COVID-19) nitazoxanide

“…The CV curves, show that the cathodic peak current increases from pH 3 to 5 and then decreases at pH 7 to 11, indicating a lack of involvement of protons required during the electrochemical sensing of NTZ. However, the pKa value of NTZ at more acidic pH was reported to be 8.3, indicating that the NTZ molecule is neutral between pH 3 and 5 ( Sukanya et al, 2021 ). Moreover, the pH is below the pKa value and the NTZ was protonated, so the unshared electron pairs are prevented from delocalizing from the N atom to the aromatic ring, which decreases the reactivity with free radical ( Feng et al, 2022 ).…”

Validated Simultaneous Derivative Spectrophotometric Estimation of Azithromycin, Fluconazole and Secnidazole in Bulk and Pharmaceutical Formulation

“…It is official in Indian Pharmacopoeia 1 . The most commonly used techniques for determining SEC in pharmaceutical dosage forms are UV spectrophotometric [31][32] , HPLC [33][34][35] , supercritical fluid chromatography 36 and electrochemical method 37 . Other method has been performed to determine SEC in biological fluids, such as polarography 38 As per our knowledge, no derivative UV spectrophotometric method has been reported for simultaneous estimation of Azithromycin, Fluconazole and Secnidazole in tablet formulation.…”