Fiber reinforced polymer (FRP) material is commonly applied in retrofitting structures due to the advantages of high strength and well corrosion resistance. Previous studies indicated that retrofitting with FRP sheet was an effective way for protecting the existing structures to resist the blast loads, but little research made comprehensive comparison study on the blast response of RC columns with different retrofitting strategies. This paper proposed a series of FRP retrofitting strategies and evaluated their effect on blast mitigation using numerical analysis approach. Comparison studies were conducted on the effect of FRP type, FRP thickness, and retrofitting mode on blast mitigation. A finite element model of RC columns retrofitted with FRP under blast loading was developed. The model considered the strain rate effect of steel and concrete and the orthotropic property of FRP composites. The reliability of the proposed model was validated against the data from a field blast test. Based on the verified model, the blast responses of RC columns with different retrofitting strategies were numerically investigated. According to the result analysis, appropriate FRP type, FRP thickness, retrofitting mode, and retrofitting length were recommended.