Background
Individuals with a negative screening colonoscopy are recommended to repeat colonoscopy in ten years.
Objective
To assess the effectiveness and costs of colonoscopy versus other rescreening strategies following a negative colonoscopy.
Design
Microsimulation model.
Data Sources
Literature and SEER.
Target Population
50-year-olds who had no adenomas or cancer detected at screening colonoscopy.
Time Horizon
Lifetime.
Perspective
Societal.
Interventions
No further screening and rescreening at age 60 with ten-yearly colonoscopy, yearly highly-sensitive guaiac fecal occult blood testing (HSFOBT), yearly fecal immunochemical testing (FIT), or five-yearly computed tomographic colonography (CTC).
Outcome Measures
Lifetime number of colorectal cancer cases, life expectancy, and lifetime costs per 1000 individuals assuming: 1) perfect adherence and 2) imperfect adherence.
Results of Base-Case Analysis
Rescreening with any modality yielded sizable reductions in colorectal cancer risk compared to no further screening (range 7.7 to 12.6 lifetime cases per 1000 (perfect adherence) and 17.7 to 20.9 lifetime cases per 1000 (imperfect adherence), versus 31.3 lifetime cases per 1000 with no further screening). For both adherence scenarios, the differences in life-years across rescreening strategies were small (range 30,893 to 30,902 per 1000 (perfect adherence) and 30,865 to 30,869 per 1000 (imperfect adherence)). Compared to continuing colonoscopy, rescreening with HSFOBT, FIT, or CTC had fewer complications and was less costly.
Results of Sensitivity Analysis
Results were sensitive to test-specific adherence rates.
Limitations
Limited data on adherence with rescreening.
Conclusions
Compared with the currently-recommended strategy of continuing ten-yearly colonoscopy after an initial negative exam, rescreening at age 60 with yearly HSFOBT, yearly FIT, or five-yearly CTC provides approximately the same benefit in life-years with fewer complications and at a lower cost. Therefore it is reasonable to rescreen individuals with a negative colonoscopy with other modalities.