Analysis of antioxidant activity and total phenolic content of some homoeopathic mother tinctures

Ahmad, Saeed; Rehman, Tayyeba; Abbasi, Waheed Mumtaz; Zaman, Muhammad Mohsin

doi:10.4103/0974-7168.200843

Cited by 13 publications

(7 citation statements)

References 1 publication

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“…100 µg/ml [21] as shown in Figure 1.. In a previous study, extracts of Hydrastis canadensis showed presence of phenolic compounds in it by using gas chromatography combined with mass spectrometry (GC-MS) Phenolic compounds have strong antioxidant potential and might be responsible for antioxidant potential of Hydrastis canadensis [22].…”

Section: R E S U L T S a N D Discussionmentioning

confidence: 88%

In Vitro Evaluation of Antioxidant Activity of Homeopathic Mother Tincture and Total Phenolic Content

Shaffique

Anwer

Asif

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Background: Antioxidants are those compounds which scavengers the free radicals, widely used in health protection and prescribed on large scale in biomedical health care units. In homeopathic system of medicine mother tinctures are prescribed. Mother tinctures of medicinal plants are having the potential to treat the various acute and chronic ailments. Objectives: The present study was accompanied to determine the total phenolic content and the antioxidant activity of homeopathic mother tincture of plant origin i.e. Baptisia tinctoria, Berberis aquifolium, Echinacea angustifolia, Hydrangea arborescens, Hydrastis canadensis, Kreosotum, and Thuja occidentalis in comparison with ascorbic acid. Methods: Antioxidant activity was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) inhibition assay method. A volume of 0.1 mM solution of DPPH was used while mother tinctures (1.25, 5, 2.5 μl volumes) were used for evaluation of antioxidant activity. Ascorbic acid was taken as a standard control and alcohol as negative control in antioxidant activity protocol. Total phenolic content was measured by Folin–Ciocalteu reagent assay. Total phenolic content of mother tinctures was measured in comparison with ascorbic acid. Results: All tested homeopathic mother tinctures of plant origin showed significant antioxidant potential except Hydrangea arborescens and Kreosotum. Alcohol which was used as negative control exhibited no antioxidant activity. Pulsatilla nigricans possess highest antioxidant potential 85±0.3 among other tested mother tinctures against DPPH free radical and 98.8±2 maximum no of phenolic contents. Conclusion: Homeopathic Mother Tinctures of plant origin showed antioxidant activity due to presence of phenolic content.

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Section: R E S U L T S a N D Discussionmentioning

confidence: 88%

In Vitro Evaluation of Antioxidant Activity of Homeopathic Mother Tincture and Total Phenolic Content

Shaffique

Anwer

Asif

et al. 2020

RADS J. Pharm. Pharm. Sci.

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“…151 Amirul Fadzli 'Aini, Siti Ernieyanti Hashim Ultrasonic-aided Optimisation of Phytochemicals and Roswanira Abdul Wahab from Ananas comosus Peel radicals (Figure 5), yielding corresponding SC50 values of 549.535±17.277 and 669.744±0.955 μg/mL, respectively (Table 4). These values indicate the presence of antioxidant compounds [17].…”

Section: Dpph Radical Scavenging Activity Of a Comosus Peel Extractsmentioning

confidence: 99%

“…Carotenoids and vitamin C typically display similarly strong antioxidant properties [18,19], whereas monophenols are regarded as weak counterparts [17,20]. Contrarily, extracts yielded via Soxhlet extraction revealed that only the chloroform extract displayed potential for scavenging 50% of the DPPH free radicals, with an SC50 value of 631.238±3.126 μg/mL (Table 5).…”

Section: Dpph Radical Scavenging Activity Of a Comosus Peel Extractsmentioning

confidence: 99%

Ultrasonic-aided Optimisation of Phytochemicals from Ananas comosus Peel

2021

MJCHEM

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Pineapple (Ananas comosus) peels contain various phytochemicals, such as antioxidants and polyphenols. In this study, ultrasound-assisted extraction (UAE) was applied to optimise the extraction of A. comosus peels by using the Central Composite Design (CCD). The extraction of ground A. comosus peels with aqueous methanol was optimised for factors including extraction time and solvent: sample and methanol: water ratios in order to identify the responding percentage yield (PY), total phenolic content (TPC), total flavonoid content (TFC), and free radicals scavenging activity by DPPH. This study also compared the extraction via Soxhlet extraction for all three responses. The UAE extracts, under conditions E18 and E20, exhibited 50% scavenging activity of DPPH free radicals with a corresponding SC50 value of 549.535±17.277 and 669.744±0.955 μg/mL, respectively. Meanwhile, Soxhlet extraction outcomes revealed that only the chloroform extract gave an SC50 value of 631.238±3.126 μg/mL. Additionally, the UAE and Soxhlet-generated extracts employed in the antibacterial assay were weakly active against Gram-positive and Gram-negative bacteria, respectively. Henceforth, this study highlights the A. comosus peels as a good source of different minor compounds, warranting further exploration using the UAE method.

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“…Reactive oxygen species represent a causal factor of the development and progression of several serious diseases, including cardiovascular disease, cancer, and neurodegenerative. The antioxidant effects of several medicinal plants, used in traditional medicine, are usually attributed to their polyphenolic compounds, flavonoids like luteolin, quercetin …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…The antioxidant effects of several medicinal plants, used in traditional medicine, are usually attributed to their polyphenolic compounds, flavonoids like luteolin, quercetin. [37] Six different types of extracts from C. absus namely petroleum ether extract, chloroform extract, ethyl acetate extract, hexane extract, butanol extract, and aqueous extract were evaluated for their antioxidant potential. Antioxidant and free radical scavenging activity was checked against free radicals DPPH, NO, and ABTS.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Phytochemistry and pharmacological potential of Cassia absus – a review

Ahmad

Hassan

Abbasi

et al. 2017

Journal of Pharmacy and Pharmacology

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Objectives Cassia absus is a plant of the family fabaceae with Ayurvedic ethnomedical records. It is used in traditional medicine for the treatment of bronchitis, asthma, cough, conjunctivitis, leucoderma, renal and hepatic diseases, constipation, tumors, venereal ulcer, headache, hemorrhoids and wound healing. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its use. This review aims to summarize reported pharmacognosy, traditional uses, phytochemistry and pharmacological potential of C. absus while identifying potential areas of further research of plant. Key findings The review comprises literature pertaining to the evidence base therapeutic potential, pharmacognosy and phytochemistry of C. absus spanning from 1935 to 2016 using published articles in peer-reviewed journals, ethno botanical text books, and worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library). Kew Botanical Garden databases and the Plant List were used to authenticate the scientific names. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of C. absus with antihypertensive, antifertility, antifungal, anti-inflammatory, anti-hyperglycemic, anti-glycation, antibacterial activity, a-amylase inhibitory activity, antioxidant and reducing activitity etc. chaksine, iso-chaksine, saturated and unsaturated fatty acids, chrysophanol, aloe-emodin and a wide range of chemical compounds have also been reported. Toxicity studies reveal the nontoxic nature of C. absus at a dose of 2000 mg/kg, however, plant possess reproductive toxicity and can be used as birth control or abortifacient. Summary Reported activities suggest that there is sufficient pharmacological potential for developing C. absus as a drug for hypertension, infections, diabetes and its complications. However, heterogeneity in study protocol and conflicting results mask the ability to replicate these studies. So, future studies should be replicated in line with best practices. More toxicological studies would aid the progress to clinical trial studies. Various ethno medical uses of C. absus have not been evaluated yet.

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Analysis of antioxidant activity and total phenolic content of some homoeopathic mother tinctures

Cited by 13 publications

References 1 publication

In Vitro Evaluation of Antioxidant Activity of Homeopathic Mother Tincture and Total Phenolic Content

In Vitro Evaluation of Antioxidant Activity of Homeopathic Mother Tincture and Total Phenolic Content

Ultrasonic-aided Optimisation of Phytochemicals from Ananas comosus Peel

Phytochemistry and pharmacological potential of Cassia absus – a review

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