Analysis of antimicrobial agents in animal feed

Borràs, Sílvia; Companyó, R.; Granados, Mercè; Guiteras, J.; Pérez-Vendrell, A. M.; Brufau, J.; Sala, Mireia Medina; Bosch, Jaume

doi:10.1016/j.trac.2011.02.012

Cited by 53 publications

(37 citation statements)

References 47 publications

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“…Food containing drug residues are considered to be a public health hazard (Chicoine 2007). When animal products with high levels of veterinary drug residues are ingested by humans, there is occurrence numerous adverse health effects like permanent gene mutation, liver poisoning (Nisha 2008), development of allergic reactions in some hypersensitive individuals, increased risk of carcinogenicity (Petrović et al 2008;Hou et al 2014), growth of resistant bacterial strains, and imbalances in intestinal microflora (Wang et al 2006;Borràs et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Penicillin-G and oxytetracycline residues in beef sold for human consumption in Maroua, Cameroon

et al. 2017

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Background: The contamination of food by chemical hazards is a worldwide public health concern and is a leading cause of trade problems internationally. Based on former work describing the prevalent use and misuse of antibiotics in cattle in the Far North Region of Cameroon, we designed a study to detect antibiotic (penicillin G and oxytetracycline) in beef sold for human consumption in Maroua (Cameroon). To determine the mean concentration of antibiotic residues in beef, sample of liver and muscle were collected from 202 cattle selected randomly in all the slaughterhouses of Maroua and Godola and analyzed using Liquid Chromatographic tandem Mass Spectrometry (LC-MS/MS). Characteristics of the cattle selected (age, sex, breed, body condition score, weight, production system, and pathology, etc.) were also collected before and/or after slaughter -by physical examination and survey, and post mortem examination. Results: Results revealed that out of 202 cattle 41 (20.30%) tested positive for antibiotics in one or more of their organs. The meat of cattle from transhumance system, sick animals and older cattle was more likely to be contained with penicillin G and oxytetracycline residues. The average residues concentration in beef was 17.58 μg/ kg for penicillin G and 240 μg/kg for oxytetracycline. Conclusions: The findings of the present study should be alarming for the legislative authorities in food security and safety. This highlights a very serious problem, both for the consumers of Maroua city and the herders of the region as well as for the whole economy of Cameroon. It is therefore be important that measures be taken at several levels by the actors of the sector (public authorities, veterinary auxiliaries, etc.) to guarantee the safety of the food of animal origin.

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Section: Introductionmentioning

confidence: 99%

Penicillin-G and oxytetracycline residues in beef sold for human consumption in Maroua, Cameroon

et al. 2017

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“…Consequently, when a compound causing the microbial growth inhibition is not within the scope of the targeted LC-MS/MS method; for example, if it is a disinfectant or a substance not registered for veterinary application, it will not be detected in such cases. Nontargeted analysis is needed to identify such 'unknown' antimicrobial compounds (Borràs et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Non-targeted workflow for identification of antimicrobial compounds in animal feed using bioassay-directed screening in combination with liquid chromatography-high resolution mass spectrometry

Wegh

Berendsen

Lankveld

et al. 2017

Food Additives & Contaminants: Part A

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A non-targeted workflow is reported for the isolation and identification of antimicrobial active compounds using bioassay-directed screening and LC coupled to high-resolution MS. Suspect samples are extracted using a generic protocol and fractionated using two different LC conditions (A and B). The behaviour of the bioactive compound under these different conditions yields information about the physicochemical properties of the compound and introduces variations in co-eluting compounds in the fractions, which is essential for peak picking and identification. The fractions containing the active compound(s) obtained with conditions A and B are selected using a microbiological effect-based bioassay. The selected bioactive fractions from A and B are analysed using LC combined with high-resolution MS. Selection of relevant signals is automatically carried out by selecting all signals present in both bioactive fractions A and B, yielding tremendous data reduction. The method was assessed using two spiked feed samples and subsequently applied to two feed samples containing an unidentified compound showing microbial growth inhibition. In all cases, the identity of the compound causing microbiological inhibition was successfully confirmed. ARTICLE HISTORY

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“…Recent reviews summarize the analytical methods reported over the past few years for the analysis of antimicrobial agents in animal feed (Borr as, Company o, Granados, et al, 2011;Kantiani, Farr e, Grases, & Barcel o, 2009). The main difficulties arise from the complexity and variability of the animal feed matrix and from the frequently low levels of the compounds to be detected.…”

Section: Introductionmentioning

confidence: 99%

Rapid multiresidue and multi-class screening for antibiotics and benzimidazoles in feed by ultra high performance liquid chromatography coupled to tandem mass spectrometry

et al. 2015

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Analysis of antimicrobial agents in animal feed

Cited by 53 publications

References 47 publications

Penicillin-G and oxytetracycline residues in beef sold for human consumption in Maroua, Cameroon

Penicillin-G and oxytetracycline residues in beef sold for human consumption in Maroua, Cameroon

Non-targeted workflow for identification of antimicrobial compounds in animal feed using bioassay-directed screening in combination with liquid chromatography-high resolution mass spectrometry

Rapid multiresidue and multi-class screening for antibiotics and benzimidazoles in feed by ultra high performance liquid chromatography coupled to tandem mass spectrometry

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