Analysis of Antiemetic Use After Initiation of Hormone Therapy

Abstract

Our results suggest that HT-related nausea may be treated with antiemetics instead of dose reduction or discontinuation. This prescribing cascade is an unintended outcome associated with HT, which our results suggest may be avoided.

Automated Detection of Missing Links in Bicycle Networks

“…Very few cities have so far managed to build up relatively safe and cohesive bicycle networks (de Groot 2016), and even the most renowned cycling cities in the world still have a long way to go to achieve a sustainable urban transport system, and an optimal cycling network. For instance, this is the case for Copenhagen, where despite over a century of political struggles and coordinated efforts to develop a functioning grid of protected on‐street bicycle networks (Carstensen et al 2015), its network of protected bicycle infrastructure is split into 300 disconnected components (Natera Orozco et al 2020a) and its accessibility displays considerable local variations (Rahbek 2020). For the assessment of an urban bicycle network, it is therefore crucial to ask: “Where are the missing links?”, “How to fix them?”, and “How much will this cost and benefit the city?” These are the questions we aim to answer in this paper.…”

Recommendations on the calculation of confidence intervals for sequence symmetry analyses

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With this letter, we would like to provide guidance on the calculation of confidence intervals when conducting a sequence symmetry analysis (SSA).The SSA is an increasingly used method for detecting drug safety signals [1][2][3] and quantifying prescription cascades. 4,5 The method is conceptually simple: Consider an exposure drug X, which causes the initiation of an outcome drug Y. If there is a causal relation between

…”

“…The SSA is an increasingly used method for detecting drug safety signals [1][2][3] and quantifying prescription cascades. 4,5 The method is conceptually simple: Consider an exposure drug X, which causes the initiation of an outcome drug Y. If there is a causal relation between…”

“…11 Further, more modern techniques such as maximum likelihood estimation and bootstrapping have been applied. 4,5,12 As can be deduced from the number of methods and formulas, the problem of obtaining valid uncertainty intervals for binomial proportions has been extensively explored by statisticians. 13 Obtaining valid uncertainty intervals for a binomial proportion is non-trivial, as an underlying probability (a continuous measure between 0 and 1) needs to be estimated using discrete numbers, limiting the probabilities that can be obtained, especially for small sample sizes.…”