Analysis of antibiotic resistance and virulence patterns inKlebsiella pneumoniaeisolated from human urinary tract infections in India

Abstract

Significance and Impact of the Study We surveyed antimicrobial resistance trends in Klebsiella pneumoniae recovered from urinary tract infection patients in Krishna district, Andhra Pradesh, India. This study revealed alarming levels of resistance against multiple antibiotics classes. To circumvent this, hospitals need to implement strict antimicrobial susceptibility testing protocols before initiating the treatment to patients. Comparison of antimicrobial resistance patterns in the same region at different time points will aid in assessing the effectiveness of interventions, establishing antibiotic resistance trends in pathogens and identifying emerging pathogens.

Patterns of Antibiotic Resistance in Urinary Tract Infections: A Retrospective Observational Study

“…Notably, nearly half of the isolates exhibited resistance to ampicillin, and there was significant resistance observed against ciprofloxacin and TMP-SMX. These results are consistent with the rising trend of fluoroquinolone and TMP-SMX resistance noted in India by Akram et al [13] and Bobbadi et al [16]. The reported resistance rates in our study surpassed those documented in studies from Bangladesh and Brazil, underscoring the urgent need for tailored antibiotic stewardship strategies in our specific context [17,18].…”