Analysis of and function predictions for previously conserved hypothetical or putative proteins in Blochmannia floridanus

Peter, Gaudermann; Vogl, Ina; Zientz, Evelyn; Silva, Francisco J.; Moya, Andrés; Gross, Roy; Dandekar, Thomas

doi:10.1186/1471-2180-6-1

Cited by 90 publications

(57 citation statements)

References 38 publications

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“…However, re-examination of 20 of the biovar 1 isolates shows characteristics of biovar 3, the dominant biovar in countries proximal to Nigeria [34]. Moreover, VNTR genotyping [35] clusters these 20 strains with biovar 3a rather than 3b, the latter being typically reported in Europe (Ducrotoy, Bertu, Moriyón, and Ocholi, unpublished results). B. melitensis has not been reported in cattle, although there is close contact with small ruminants.…”

Section: Resultsmentioning

confidence: 89%

Brucellosis as an Emerging Threat in Developing Economies: Lessons from Nigeria

et al. 2014

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Nigeria is the most populous country in Africa, has a large proportion of the world's poor livestock keepers, and is a hotspot for neglected zoonoses. A review of the 127 accessible publications on brucellosis in Nigeria reveals only scant and fragmented evidence on its spatial and temporal distribution in different epidemiological contexts. The few bacteriological studies conducted demonstrate the existence of Brucella abortus in cattle and sheep, but evidence for B. melitensis in small ruminants is dated and unclear. The bulk of the evidence consists of seroprevalence studies, but test standardization and validation are not always adequately described, and misinterpretations exist with regard to sensitivity and/or specificity and ability to identify the infecting Brucella species. Despite this, early studies suggest that although brucellosis was endemic in extensive nomadic systems, seroprevalence was low, and brucellosis was not perceived as a real burden; recent studies, however, may reflect a changing trend. Concerning human brucellosis, no studies have identified the Brucella species and most reports provide only serological evidence of contact with Brucella in the classical risk groups; some suggest brucellosis misdiagnoses as malaria or other febrile conditions. The investigation of a severe outbreak that occurred in the late 1970s describes the emergence of animal and human disease caused by the settling of previously nomadic populations during the Sahelian drought. There appears to be an increasing risk of re-emergence of brucellosis in sub-Saharan Africa, as a result of the co-existence of pastoralist movements and the increase of intensive management resulting from growing urbanization and food demand. Highly contagious zoonoses like brucellosis pose a threat with far-reaching social and political consequences.

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Section: Resultsmentioning

confidence: 89%

Brucellosis as an Emerging Threat in Developing Economies: Lessons from Nigeria

et al. 2014

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“…In general, the overall dominance of the T genotype resembles the distribution pattern in Horn of Africa countries, suggesting a similar trend of transmission. 30 …”

Section: Discussionmentioning

confidence: 99%

Molecular typing of mycobacteria isolated from tuberculous lymphadenitis cases in Addis Ababa, Ethiopia

Zewdie

Mihret

Ameni

et al. 2016

int j tuberc lung dis

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SUMMARY BACKGROUND In Ethiopia, one of the world’s 22 high tuberculosis (TB) burden countries, one third of the tuberculosis (TB) cases are attributed to tuberculosis lymphadenitis (TBLN). However, information on the molecular type of the mycobacterial species and strains that cause TBLN in the country is scarce. OBJECTIVE To identify the species and strains of mycobacteria that cause TBLN in Ethiopia. METHODS AND RESULTS A cross-sectional study was conducted among 206 presumed TBLN cases to characterise positive culture isolates. Mycobacterium tuberculosis complex species and strains were identified using region of difference 9 deletion and SITVIT WEB, respectively. Of the 206 fine-needle aspirate samples collected, 74 (36%) were culture-positive: 73 (98.6%) of the isolates were M. tuberculosis, and the remaining 1.4% were M. bovis. Further characterisation of the 73 M. tuberculosis isolates led to 26 distinct spoligotype international types (SITs) and 13 newly identified patterns. The most prevalent strains were SIT149, SIT53, SIT26 and SIT37 of sublineages T3-ETH, T1, CASI-DELHI and T3, respectively; these accounted for 52.6% of the total number of strains. CONCLUSION TBLN was mainly caused by M. tuberculosis and highly clustered strains SIT149, SIT53, SIT26 and SIT37 of sublineages T3-ETH, T1, CASI-DELHI and T3, respectively.

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“…Nontyphoidal salmonellosis is one of the most common causes of foodborne diarrheal disease worldwide and remains a major public health problem in many parts of the world [7]. It is often implicated in over 60% of cases of human salmonellosis in Europe and North America [8], Latin America, the Middle East, and Africa [9], also in countries such as India [10], Japan [11], and the United States [12]. Several studies had documented isolation of nontyphoidal Salmonella from humans and poultry in different parts of Nigeria [13,14].…”

Section: Introductionmentioning

confidence: 99%

Occurrence and antimicrobial resistance of pathogenic Escherichia coli and Salmonella spp. in retail raw table eggs sold for human consumption in Enugu state, Nigeria

et al. 2016

Vet World

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Aim:This study was conducted to investigate the occurrence of pathogenic Escherichia coli and Salmonella species in retail raw table eggs sold for human consumption in Enugu State and to determine the resistance of these pathogens to antimicrobials commonly used in human and veterinary practices in Nigeria.Materials and Methods:A total of 340 raw table eggs comprising 68 composite samples (5 eggs per composite sample) were collected from five selected farms (13 composite samples from the farms) and 10 retail outlets (55 composite samples from the retail outlets) in the study area over a period of 4-month (March-June, 2014). The eggs were screened for pathogenic E. coli and Salmonella species following standard procedures within 24 h of sample collection. Isolates obtained were subjected to in-vitro antimicrobial susceptibility test with 15 commonly used antimicrobials using the disk diffusion method.Results:About 37 (54.4%) and 7 (10.3%) of the 68 composite samples were positive for pathogenic E. coli and Salmonella species, respectively. The shells showed significantly higher (p<0.05) contaminations than the contents for both microorganisms. The eggs from the farms showed higher contamination with pathogenic E. coli than eggs from the retail outlets while the reverse was the case for Salmonella species even though they were not significant (p>0.05). The organisms obtained showed a multiple drug resistance. They were completely resistant to nitrofurantoin, sulfamethoxazole/trimethoprim, penicillin G and oxacillin. In addition to these, Salmonella spp. also showed 100% resistance to tetracycline. The pathogenic E. coli isolates obtained were 100% susceptible to gentamicin, neomycin, ciprofloxacin, and amoxicillin-clavulanic acid while Salmonella spp. showed 100% susceptibility to erythromycin, neomycin, and rifampicin. Both organisms showed varying degrees of resistance to streptomycin, amoxicillin, vancomycin, and doxycycline.Conclusion:From the results of the study, it can be concluded that the raw table eggs marketed for human consumption in Enugu State, Nigeria is contaminated with pathogenic E. coli and Salmonella species that showed multiple drug resistance to antimicrobial agents commonly used in veterinary and human practice.

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Analysis of and function predictions for previously conserved hypothetical or putative proteins in Blochmannia floridanus

Cited by 90 publications

References 38 publications

Brucellosis as an Emerging Threat in Developing Economies: Lessons from Nigeria

Brucellosis as an Emerging Threat in Developing Economies: Lessons from Nigeria

Molecular typing of mycobacteria isolated from tuberculous lymphadenitis cases in Addis Ababa, Ethiopia

Occurrence and antimicrobial resistance of pathogenic Escherichia coli and Salmonella spp. in retail raw table eggs sold for human consumption in Enugu state, Nigeria

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