Analysis of Alkaloids from<i>Physalis peruviana</i>by Capillary GC, Capillary GC-MS, and GC-FTIR

Kubwabo, Cariton; Rollmann, Bruno; Tilquin, Bernard

doi:10.1055/s-2006-959634

Cited by 13 publications

(2 citation statements)

References 4 publications

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“…51). Furthermore, it is very likely that Physalis floridana contains TAs as well because Physalis peruviana, another species in the Physalis genus, contains tropine 47 . It would be interesting to investigate TAs content and biosynthesis in P. floridana in the future.…”

Section: Discussionmentioning

confidence: 99%

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

et al. 2023

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Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted to certain species/tribes in this family. Little is known about the genomic basis and evolution of TAs biosynthesis and specialization in the Solanaceae. Here, we present chromosome-level genomes of two representative mTAs-producing species: Atropa belladonna and Datura stramonium. Our results reveal that the two species employ a conserved biosynthetic pathway to produce mTAs despite being distantly related within the nightshade family. A conserved gene cluster combined with gene duplication underlies the wide distribution of TAs in this family. We also provide evidence that branching genes leading to mTAs likely have evolved in early ancestral Solanaceae species but have been lost in most of the lineages, with A. belladonna and D. stramonium being exceptions. Furthermore, we identify a cytochrome P450 that modifies hyoscyamine into norhyoscyamine. Our results provide a genomic basis for evolutionary insights into the biosynthesis of TAs in the Solanaceae and will be useful for biotechnological production of mTAs via synthetic biology approaches.

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Section: Discussionmentioning

confidence: 99%

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

et al. 2023

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“…The roots of P. peruviana also contain the secotropane alkaloids physoperuvine and (+)-N,N-dimethyl-physoperuvinium salt [ 46 ]. The leaves and roots contain tropine, 3α-tigloyloxytropane, 3β-acetoxytropane and physoperuvine [ 47 ]. The roots of the related P. alkekengi contain the calystegines A 3 , A 5 , B 1 , B 2 and B 3 [ 48 ].…”

Section: Tas In Food In Europementioning

confidence: 99%

Emerging Issues on Tropane Alkaloid Contamination of Food in Europe

Nijs

Crews

Dorgelo

et al. 2023

Toxins

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The occurrence of tropane alkaloids (TAs), toxic plant metabolites, in food in Europe was studied to identify those TAs in food most relevant for human health. Information was extracted from the literature and the 2016 study from the European Food Safety Authority. Calystegines were identified as being inherent TAs in foods common in Europe, such as Solanum tuberosum (potato), S. melongena (eggplant, aubergine), Capsicum annuum (bell pepper) and Brassica oleracea (broccoli, Brussels sprouts). In addition, some low-molecular-weight tropanes and Convolvulaceae-type TAs were found inherent to bell pepper. On the other hand, atropine, scopolamine, convolvine, pseudotropine and tropine were identified as emerging TAs resulting from the presence of associated weeds in food. The most relevant food products in this respect are unprocessed and processed cereal-based foods for infants, young children or adults, dry (herbal) teas and canned or frozen vegetables. Overall, the occurrence data on both inherent as well as on associated TAs in foods are still scarce, highlighting the need for monitoring data. It also indicates the urge for food safety authorities to work with farmers, plant breeders and food business operators to prevent the spreading of invasive weeds and to increase awareness.

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Ornithine-Derived Alkaloids

2008

Solanaceae and Convolvulaceae: Secondary Metabolites

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Analysis of Alkaloids fromPhysalis peruvianaby Capillary GC, Capillary GC-MS, and GC-FTIR

Cited by 13 publications

References 4 publications

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

Emerging Issues on Tropane Alkaloid Contamination of Food in Europe

Ornithine-Derived Alkaloids

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