Analysis of advanced glycation end products in the DHS Mind Study

Abstract

Aims Human studies of links between advanced glycation end-products (AGEs) and disease phenotypes are less common than studies of animal and cell models. Here, we examined the association of total AGEs with diabetes risk factors in a predominately type 2 diabetes (T2D) affected cohort. Methods AGEs were measured using an enzyme linked immunosorbant assay in 816 individuals from the DHS Mind Study (n=709 T2D affected), and association analyses were completed. Results Total AGEs were associated with estimated glomerular filtration rate (p= 0.0054; β= −0.1291) and coronary artery calcification (p= 0.0352; β= 1.1489) in the entire cohort. No significant associations were observed when individuals with T2D were analyzed separately. In individuals without T2D, increased circulating AGEs were associated with increased BMI (p= 0.02, β = 0.138), low density lipoproteins (p=0.046, β = 17.07) and triglycerides (p= 0.0004, β = 0.125), and decreased carotid artery calcification (p= 0.0004, β = −1.2632) and estimated glomerular filtration rate (p= 0.0018, β = −0.1405). Strong trends were also observed for an association between AGEs and poorer cognitive performance on the digit symbol substitution test (p=0.046, β = −6.64) and decreased grey matter volume (p=0.037, β = −14.87). Conclusions AGEs may play an important role in a number of phenotypes and diseases, although not necessarily in interindividual variation in people with T2D. Further evaluation of specific AGE molecules may shed more light on these relationships.

The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders

“…The incidence of cognitive impairment was higher in those with high or mid pentosidine levels than those in the lowest tercile (odds ratio = 1.55; 95% CI: 1.07-2.26). Similarly, circulating AGEs have been associated with poorer cognitive performance on the digit substitution test in a cohort of people predominantly diagnosed with T2DM [114]. In the same study, decreased grey matter volume was also observed in people without T2DM with higher AGE consumption.…”

“…Several studies have investigated the association of circulating and tissue AGE levels with cognition [18,[114][115][116][117][118][119][120]. Most studies focused on blood AGEs, rather than dietary AGEs or interventions that modify dietary AGEs.…”

Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases

“…As for variants of MT1A, significant association of rs964372 exists with diabetic neuropathy (linked to hyperlipidemia) [60] (as for MT2A, see below). More recently, rs7198427 and rs7197489, initially attributed to the MT1A gene portion, were identified by genome-wide association study (GWAS) as associated to advanced glycation endproducts (AGEs) in diabetic subjects [62].…”

Peritoneal dialysis and peritoneal fibrosis: molecular mechanisms, risk factors and prospects for prevention

“…Крім того, було продемонстровано, що ПДГ, депоновані в інтерстиції і стінках судин, корелюють з розвитком фіброзу, транспортною характеристикою мембрани, рівнем ультрафільтрації та кардіоваскулярною смертністю [24,25]. Формуванню ПДГ сприяє уремія, цукровий діабет, та інші дегенеративні захворювання, які асоційовані зі збільшенням молекулярного субстрату та оксидативним стресом [4,27].…”