Analysis of a Minimally Invasive Intracranial Pressure Signals During Infusion at the Subarachnoid Spinal Space of Pigs

Frigieri, Gustavo; Andrade, Rodrigo; Wang, C. C.; Junior, Deusdedit Lineu Spavieri; Lopes, Luiza Silva; Brunelli, R.; Cardim, Danilo; Verzola, R. M. M.; Mascarenhas, S.

doi:10.1007/978-3-319-65798-1_16

Cited by 12 publications

(14 citation statements)

References 5 publications

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“…In another study, the same non-invasive sensor used in rats was placed over the skull and a Codman micro transducer was inserted into the brain parenchyma of an anaesthetised pig. Both sensors were attached to the Braincare CR15 device for simultaneous minimally invasive and invasive ICP monitoring during induction of increased ICP through the infusion of saline into the lumbar spinal subarachnoid space (Frigieri et al 2018b). Subsequently, the device has been modified to become totally non-invasive and was tested in seven rats, comparing an invasive intraparenchymal pressure monitoring Codman MicroSensor system with the non-invasive device while saline was infused into the lumbar subarachnoid space to increase the ICP.…”

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of a non‐invasive device for monitoring intracranial pressure waveforms in dogs

Arias¹,

Conceição

Guimarães

et al. 2022

J of Small Animal Practice

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The objective of this study was to compare waveforms obtained with a new device for the non-invasive monitoring of intracranial pressure (ICP) in dogs with and without neurological disease. Materials and MethOds:This prospective study was conducted on both neurologically normal dogs and dogs with neurological diseases. First, non-invasive ICP waveforms were recorded in normal dogs using the Braincare® BcMM 2000 monitor while the dogs were under general anaesthesia induced for procedures unrelated to this study. The dogs were positioned in lateral recumbency, and the sensor was placed over the skin of the parietal region. Secondly, non-invasive ICP waveforms were monitored in dogs with brain and spinal disease until waveforms with characteristic peaks were acquired. All the recorded signals were amplified, filtered and digitalized, by the device, and then transferred to a computer for analysis.results: Normal pulse waveforms indicating normal brain complacency were observed in eight neurologically normal dogs. In six dogs with brain disease, abnormal pulse waveforms were observed suggesting increased ICP and decreased brain complacency. Four dogs with spinal disease undergoing myelography, had normal waveforms before contrast medium injection and abnormal pulse waveforms during contrast medium injection, indicating a potential increase in ICP. clinical significance: Based on these preliminary observations, this method was capable of detecting abnormal pulse waveforms that suggested increased ICP.

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Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of a non‐invasive device for monitoring intracranial pressure waveforms in dogs

Arias¹,

Conceição

Guimarães

et al. 2022

J of Small Animal Practice

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“…The graphic result of the ICP waveform measurement consists in three characteristic peaks: P1, representing the arterial pressure being exerted from the choroid plexus to the ventricle, known as the percussion wave ; P2, associated to the brain compliance, known as the tidal wave ; and P3, which is the dicrotic wave . Under normal circumstances, the waves are presented as P1 > P2 > P3 (Cabella et al, 2016 ; Ballestero et al, 2017 ; Frigieri et al, 2018b ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Untreatable Headache in a Child With Ventriculoperitoneal Shunt Managed by Use of New Non-invasive Intracranial Pressure Waveform

Paraguassu

Khilnani²,

Rabelo³

et al. 2021

Front. Neurosci.

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brain4care, a new Food and Drug Administration (FDA)-cleared non-invasive sensor that monitors intracranial pressure waveforms, was used in a 13-year-old girl who presented with untreatable headaches. The patient had a history of craniopharyngioma resection and a ventriculoperitoneal shunt placement 7 years prior to the use of the device. Secondary obstructive hydrocephalus was also a present factor in the case. The hypothesis was that due to the hydrocephalus, the child presented chronic headaches and needed constant readjustment into the ventriculoperitoneal shunt to regulate the cerebrospinal fluid inside her ventricles in order to control the patient's intracranial pressure (ICP). The device was chosen considering the risks to submit a patient into the regular invasive method to measure ICP. It was identified that the device could also indicate altered intracranial compliance due to the ratio between the P1 and P2 amplitudes (P2/P1 ratio > 1).

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“…Recently, the development of a non-invasive system to evaluate the ICPW (nICPW) allowed assessing the behavior of ICPW beyond the neurointensive care environment. This method has clinically [9,13,14] and experimentally [15,16] demonstrated a high correlation with its invasive predicate, reproducing the same pulse shape profile and extracting numerical parameters from its different peaks amplitudes.…”

Section: Introductionmentioning

confidence: 95%

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

Ideta¹,

Oliveira²,

Gonçalves³

et al. 2023

Preprint

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Background: Due to the importance of brain death (BD) diagnostic do not mistake, reliable confirmatory exams should be performed to enhance its security. This study aims to evaluate the intracranial pressure (ICP) pulse morphology behavior in brain-dead patients through a noninvasive monitoring system. Methods: A pilot case-control study was conducted in adults that met the BD national protocol criteria. Quantitative data from the ICP waveforms were extracted and analyzed comparing BD patients and health subjects. Results: Fifteen patients were included. ICP waveforms presented substantial differences amidst BD patients when compared to the control group. Moreover, pulse amplitude and time to peak variables values in the case group were also statistically significant. Conclusions: In this exploratory study, noninvasive ICP waveforms have shown potential as a screening method in patients with suspected brain death. Future studies should be carried out in a larger population.

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Analysis of a Minimally Invasive Intracranial Pressure Signals During Infusion at the Subarachnoid Spinal Space of Pigs

Abstract: The ICPMI signal trends showed a good linear agreement with the signal obtained invasively. Based on the waveform analysis of the pulsatile component of ICP, our results indicate the possibility of using the minimally invasive method for assessing the neuroclinical state of the patient.

Cited by 12 publications

References 5 publications

Preliminary evaluation of a non‐invasive device for monitoring intracranial pressure waveforms in dogs

Preliminary evaluation of a non‐invasive device for monitoring intracranial pressure waveforms in dogs

Case Report: Untreatable Headache in a Child With Ventriculoperitoneal Shunt Managed by Use of New Non-invasive Intracranial Pressure Waveform

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

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