Analysis of 3D printing possibilities for the development of practical applications in synthetic organic chemistry

Gordeev, Evgeniy G.; Degtyareva, Evgeniya S.; Ananikov, Valentine P.

doi:10.1007/s11172-016-1492-y

Cited by 42 publications

(25 citation statements)

References 39 publications

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“…The advent of 3D printing has brought further interest to PLA because PLA can easily be printed using simple and low cost approaches such as fused deposition modelling (FDM) [ 6 , 7 ]. 3D printing is interesting for the general area of biomaterials development because, in principle, it may be possible to provide patient-specific implants on-site and on-demand [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Surface Etching of 3D Printed Poly(lactic acid) with NaOH: A Systematic Approach

et al. 2020

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The article describes a systematic investigation of the effects of an aqueous NaOH treatment of 3D printed poly(lactic acid) (PLA) scaffolds for surface activation. The PLA surface undergoes several morphology changes and after an initial surface roughening, the surface becomes smoother again before the material dissolves. Erosion rates and surface morphologies can be controlled by the treatment. At the same time, the bulk mechanical properties of the treated materials remain unaltered. This indicates that NaOH treatment of 3D printed PLA scaffolds is a simple, yet viable strategy for surface activation without compromising the mechanical stability of PLA scaffolds.

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Section: Introductionmentioning

confidence: 99%

Surface Etching of 3D Printed Poly(lactic acid) with NaOH: A Systematic Approach

et al. 2020

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“…This wide choice of printable materials is one of most significant advantages of these 3D printers, which are also relatively inexpensive and easy‐to‐handle. Unfortunately, not all the materials are useful for practical applications in organic synthesis and in some cases the fumes generated during the heating at high temperature of thermoplastic materials could be a potential health hazard (as for the PEEK printing process). However, the possibility to place the 3D printer in a hood (always present in a chemical lab) can easily solve any problems coming from the vast majority of common thermoplastics,.…”

Section: D Printing Technologiesmentioning

confidence: 99%

Additive Manufacturing Technologies: 3D Printing in Organic Synthesis

2018

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The manufacturing of a three‐dimensional product from a computer‐driven digital model (3D printing) has found extensive applications in several fields. Additive manufacturing technologies offer the possibility to fabricate ad hoc tailored products on demand, at affordable prices, and have been employed to make customized and complex items for actual sale. However, despite the great progress and the countless opportunities offered by the 3D printing technology, surprisingly a relatively limited number of applications have been documented in organic chemistry. This Minireview will focus specifically on the exploitation of additive manufacturing technologies in the synthesis of organic compounds, and, in particular, on the use of 3D‐printed catalysts and 3D printed reactors, and on the fabrication and use of 3D printed flow reactors.

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“…3D‐printing has emerged strongly in recent years, enabling the manufacture of reactors for chemical solution as well as monoliths . Cronin demonstrated the utility of this technology in the manufacture of chemical reactionware, particularly for reactors used in classical linear drug synthesis in solution phase chemistry .…”

Section: Introductionmentioning

confidence: 99%

“…For these reasons, research regarding monolithic catalysts that immobilize palladium species [15][16][17][18] on their surface remains an area of continuous and productive research. 3D-printing has emerged strongly in recent years, enabling the manufacture of reactors [19] for chemical solution as well as monoliths. [20,21] Cronin demonstrated the utility of this technology in the manufacture of chemical reactionware, particularly for reactors used in classical linear drug synthesis in solution phase chemistry.…”

Section: Introductionmentioning

confidence: 99%

Integrating Reactors and Catalysts through Three‐Dimensional Printing: Efficiency and Reusability of an Impregnated Palladium on Silica Monolith in Sonogashira and Suzuki Reactions

et al. 2020

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For this work, an integrated system composed of a polypropylene reactor and a palladium on silica monolithic catalyst was designed and manufactured by 3D‐printing. These devices are able to perform solution phase chemistry in a robotic orbital shaker. The capped reactor was obtained in its entirety by 3D‐printing, using polypropylene and fused deposition modeling. The monolithic catalyst was also obtained by 3D‐printing ‐robocasting‐ of a silica support, sintering and subsequent palladium deposition through the wet impregnation method. The catalytic efficiency in Sonogashira or Suzuki reactions as well as the recyclability of the entire system – catalyst+reactor – were studied. The strong electrostatic adsorption (SEA) of the palladium on sintered silica and the reduced mechanical stress produced by the convenient adjustment of the catalyst into the polypropylene reactor makes the catalytic system reusable without significant loss of catalytic activity.

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Analysis of 3D printing possibilities for the development of practical applications in synthetic organic chemistry

Cited by 42 publications

References 39 publications

Surface Etching of 3D Printed Poly(lactic acid) with NaOH: A Systematic Approach

Surface Etching of 3D Printed Poly(lactic acid) with NaOH: A Systematic Approach

Additive Manufacturing Technologies: 3D Printing in Organic Synthesis

Integrating Reactors and Catalysts through Three‐Dimensional Printing: Efficiency and Reusability of an Impregnated Palladium on Silica Monolith in Sonogashira and Suzuki Reactions

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