Analyse des facteurs prédictifs de malignité des goitres nodulaires : à propos de 500 cas

Bouaity, Brahim; Darouassi, Youssef; Chihani, Mehdi; Touati, Mohamed; Ammar, Haddou

doi:10.11604/pamj.2016.23.88.8405

Cited by 5 publications

(6 citation statements)

References 6 publications

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“…The average age of the patients in the present series agrees with the results of other African studies [ 26 , 41 , 42 ]. The 658 patients with thyroid nodules were older than those without thyroid nodules.…”

Section: Discussionsupporting

confidence: 92%

“…The multiplication of nodules with aging can be at least partly accounted for by the delay in seeking appropriate care. The delay to consultation in our patients with thyroid nodules amounted to 3 years or more in almost half of them, which is in keeping with other studies [ 26 , 48 ] that reported that patients with thyroid nodules consulted the doctor late. Furthermore, the thyroid function was unaltered in the majority of cases with thyroid nodules.…”

Section: Discussionsupporting

confidence: 91%

“…The main patient complaints in our study are similar to those usually reported in the literature [ 26 , 35 , 42 ]. When present, signs of compression and aesthetic concerns motivate most consultations in Congo.…”

Section: Discussionsupporting

confidence: 90%

“…Genetic predisposition and environmental features could be invoked to explain the susceptibility to thyroid nodules, as 35.5% and 49.1% of patients with thyroid nodules reported a family history of goiter and a history of residence in iodine-deficient zones. The family notion of goiter is a known risk factor associated with thyroid nodules [ 33 , 42 , 50 ], especially among twins [ 26 ]. The notion of family history of goiter and of residence in given iodine-deficient zones should be capitalized upon to undertake prospective surveys, with the aim to identify potential genetic and environmental causes and their relationships with thyroid nodules in Congolese people.…”

Section: Discussionmentioning

confidence: 99%

“…Advanced age, iodine deficiency, female sex, obesity, radiation (especially to the cervical region) and a family notion of thyroid diseases are the important risk factors associated with the occurrence of nodules in the general population [ 24 , 25 , 26 , 27 , 28 ]. The literature [ 5 , 29 ] supports that 5 to 10% of these nodules are cancers.…”

Section: Introductionmentioning

confidence: 99%

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The Spectrum of Thyroid Nodules at Kinshasa University Hospital, Democratic Republic of Congo: A Cross-Sectional Study

Bukasa

Bayauli-Mwasa

Mbunga

et al. 2022

IJERPH

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We analyzed the spectrum of thyroid nodules in patients attending the endocrinology unit care of the Kinshasa University Hospital and assessed their associated factors. We conducted a cross-sectional study, performing descriptive statistics and logistic regression. From the 888 enrolled patients, thyroid nodules were detected in 658 patients (74.1%), as mononodules in 22.5% and multiple nodules in 77.5%. Thyroid function was normal in 71.3% cases, while hyperthyroidism and hypothyroidism were found in 26.1% and 2.6% of cases, respectively. Women were more affected than men (75.1% vs. 63.6%; p = 0.03). Patients with thyroid nodules were older (44 ± 12 vs. 38 ± 12 years; p < 0.001), with a family history of goiter (38.3% vs. 27.4%; p = 0.003) and residence in the iodine-deficient region (51.7% vs. 38.8%; p = 0.012); they had a higher proportion of longer delays to consultation (47% vs. 20%; p < 0.001), but a higher rate of normal thyroid function (85.5% vs. 3 1.3%; p < 0.001). Thyroid nodules were associated with the delay to consultation (for duration ≥ three years, OR: 6.560 [95% CI: 3.525–12.208)], multiparity (present vs. absent: 2.863 [1.475–5.557]) and family history of goiter (present vs. absent: 2.086 [95% CI:1.231–3.534]) in female patients alone. The high frequency of thyroid nodules observed requires measures aimed at early detection in the population, the training of doctors involved in the management and the strengthening of technical platforms in our hospitals.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Spectrum of Thyroid Nodules at Kinshasa University Hospital, Democratic Republic of Congo: A Cross-Sectional Study

Bukasa

Bayauli-Mwasa

Mbunga

et al. 2022

IJERPH

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Ultrasound performance using the EU-TIRADS score in the diagnosis of thyroid cancer in Congolese hospitals

Bukasa-Kakamba

Bayauli

Sabbah

et al. 2022

Sci Rep

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The thyroid imaging reporting and data systems by the European Thyroid Association (EU-TIRADS) has been widely used in malignancy risk stratification of thyroid nodules. However, there is a paucity of data in developing countries, especially in Africa, to validate the use of this scoring system. The aim of the study was to assess the diagnostic value of the EU-TIRADS score in Congolese hospitals, using pathological examination after surgery as the gold standard in Congolese hospitals. This retrospective and analytical study examined clinical, ultrasound and pathological data of 549 patients aged 45 ± 14 years, including 468 females (85.2%), operated for thyroid nodule between January 2005 and January 2019. In the present study, only the highest graded nodule according to the EU-TIRADS score in each patient was taken into account for the statistical analyses. So 549 nodules were considered. Nodules classified EU-TIRADS 2 and 3 on the one hand, and, on the other hand, 4 and 5, were considered respectively at low and high risk of malignancy. The sensitivity and specificity of the EU-TIRADS score were calculated. The significance level was set at 5%. Of all patients, 21.7% had malignant nodules. They made 48.4% of the nodules in patients younger than and at 20 years old, and 31.1% in those aged 60 or over. Malignant nodules were more frequent in men than in women (30.9% vs. 20.1%; p = 0.024). Papillary carcinoma (67.2%) and follicular carcinoma (21.8%) were the main types. The malignancy rate was 39.7% and 1.5% among nodules rated EU-TIRADS 4 and 5, and those with EU-TIRADS score 2 and 3, respectively (p < 0.001). The EU-TIRADS score had a sensitivity of 96.6% and a specificity of 59.3%. The ROC curve indicated an area under the curve of 0.862. In a low-income country, a well performed thyroid ultrasound, using the EU-TIRADS score, could be an important tool in the selection of thyroid nodules suspected of malignancy and requiring histopathological examination in the Congolese hospital setting.Trial registration: The research protocol had obtained the favorable opinion of the DRC national health ethics committee no. 197/CNES/BN/PMMF/2020. The data was collected and analyzed anonymously.

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Clinical, Laboratory, Ultrasound and FNB aspects of thyroid nodules with calcifications

Gabarra¹

2019

Open J Thyroid Res

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Thyroid nodules are very frequent in the general population, with a low occurrence of malignancy among them. The present study was conducted on 517 patients of both sexes recruited at the Endocrinology Ambulatory of UNAERP, a secondary health service. The sample consisted of 464 women (80.97%) and 53 men (20.03%) with thyroid nodules ranging in age from 15 to 89 years (mean: 52.3 years; 51.8 years for women and 57.1 years for men). A total of 1808 nodules were investigated (1468 in women and 340 in men) and 67 lesions with calcifi cation were detected, 14 of them classifi ed as malignant. Standard ultrasound of the 67 nodules revealed that 53 lesions were hypoechoic, 7 were hyperechoic, and 7 isoechoic. Of the 14 malignant lesions, 8 (57%) were classifi ed as hypoechoic, 3 (21.5%) as isoechoic, and 3 as hyperechoic (21.5%), with 6 of them containing microcalcifi cations, 4 containing macrocalcifi cations, 3 peripheral calcifi cations, and 1 a mixed calcifi cation. TI-RADS classifi cation of the 14 lesions showed that one (7.2%) was TI-RADS 3, 6 (42.8) TI-RADS 5, and 7 (50%) TI-RADS 6; being 92.8% of the malignant lesions TI-RADS 5 and 6. The BETHESDA classifi cation for FNB of the malignant lesions was: 1 case as B2, 2 cases as B3, 1 case as B4, 5 cases (35.72%) as B5 (suspected as malignant), and 6 (42.72%) as B6 (carcinoma). Three of these 14 lesions (21.42%) showed invasion of the capsule and/or neighboring tissues. Among the malignant lesions, the TI-RADS and BETHESDA classifi cations were most associated with the diagnosis of malignancy in the anatomopathological exam of the excised lesions.

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Analyse des facteurs prédictifs de malignité des goitres nodulaires : à propos de 500 cas

Cited by 5 publications

References 6 publications

The Spectrum of Thyroid Nodules at Kinshasa University Hospital, Democratic Republic of Congo: A Cross-Sectional Study

The Spectrum of Thyroid Nodules at Kinshasa University Hospital, Democratic Republic of Congo: A Cross-Sectional Study

Ultrasound performance using the EU-TIRADS score in the diagnosis of thyroid cancer in Congolese hospitals

Clinical, Laboratory, Ultrasound and FNB aspects of thyroid nodules with calcifications

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