Analyse der Venenbewegungen in der Netzhaut von Glaukompatienten

Ghanem, Mohamed; Gugleta, Konstantin; Oettli, A.; Kochkorov, Asan; Polunina, Anna; Orgül, Selim

doi:10.1055/s-0032-1328361

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…In glaucomatous eyes, retinal veins in the immediate vicinity of, as well as away from the optic disc, demonstrated lower pulse amplitudes than in healthy eyes, indicating disturbances in venous outflow and increased intraluminal venous pressure and resistance. [ 14 , 15 ] Morgan et al suggested that such a gradual increase in central retinal vein resistance may be implicated in central retinal vein occlusions, shunt vessels, and ODHs. [ 12 ] In addition, ODH occurs up to 4 times more frequently in normal-tension glaucoma (NTG) than in primary open-angle glaucoma (POAG) patients with baseline intraocular pressure (IOP) of more than 21 mmHg.…”

Section: Introductionmentioning

confidence: 99%

Central Retinal Venous Pressure in Eyes of Normal-Tension Glaucoma Patients with Optic Disc Hemorrhage

Kim

2015

PLoS ONE

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ObjectiveTo compare central retinal venous pressure (CRVP) among eyes with and without optic disc hemorrhage (ODH) in bilateral normal-tension glaucoma (NTG) patients and NTG eyes without an episode of ODH.MethodsIn this prospective study, 22 bilateral NTG patients showing a unilateral ODH and 29 bilateral NTG patients without an episode of ODH were included. Eyes were categorized into group A (n = 22, eyes with ODH), group B (n = 22, fellow eyes without ODH), and group C (n = 29, NTG eyes without an episode of ODH). A contact lens ophthalmodynamometer was used to measure CRVP and central retinal arterial pressure (CRAP).ResultsIntraocular pressure (IOP) measured on the day of contact lens ophthalmodynamometry showed no difference among groups. However, the mean baseline IOP in group A was significantly lower than that in group C (P = .008). The CRVP in group A (29.1 ± 10.8 mmHg) was significantly lower than that in group C (40.1 ± 8.8 mmHg, P = .001), but similar to that in group B (30.5 ± 8.7 mmHg, P = .409). A similar relationship was noted for CRAP. No significant eye-associated variable for ODH was found in group A and B by conditional logistic regression analysis (all P > 0.05). However, multivariate logistic regression analysis in groups A and C revealed that low mean baseline IOP (odds ratio [OR] = 0.69, 95% confidence interval [CI] 0.49-0.98, P = 0.043) and low CRVP (OR = 0.88, 95% CI 0.80-0.95, P = 0.003) were associated with ODH.ConclusionsCRVP was lower in NTG eyes with ODH than in eyes without an episode of ODH, but similar to that of fellow eyes without ODH. These imply less likelihood of association between increased central retinal venous resistance and ODH.

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Section: Introductionmentioning

confidence: 99%

Central Retinal Venous Pressure in Eyes of Normal-Tension Glaucoma Patients with Optic Disc Hemorrhage

Kim

2015

PLoS ONE

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“…RVP was increased in glaucoma [314], and correspondingly, the pulse amplitude in these veins was lower [315]. Eyes with optic disc haemorrhages did not have higher RVP but did have lower retinal arterial pressures in comparison to both the contralateral eyes and eyes of control patients matched for BP [253].…”

Section: Retinal Venous Pressurementioning

confidence: 99%

The discovery of the Flammer syndrome: a historical and personal perspective

Flammer

Konieczka

2017

EPMA Journal

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This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels. Their retinal vessels were more rigid and irregular and responded less to flickering light. Holistic investigation demonstrated low blood pressure, silent myocardial ischaemia, altered beat-to-beat variation, altered gene expression in the lymphocytes, slightly increased plasma endothelin level and increased systemic oxidative stress. This combination of signs and symptoms was better described by the term primary vascular dysregulation (PVD) than by VS. Subsequent studies showed additional symptoms frequently related to PVD, such as low body mass index, cold extremities combined with slightly increased core temperature, prolonged sleep onset time, reduced feelings of thirst, increased sensitivity to smell and also for certain drugs and increased retinal venous pressure. To better characterise this entire syndrome, the term Flammer syndrome (FS) was introduced. Most subjects with FS were healthy. Nevertheless, FS seemed to increase the risk for certain eye diseases, particularly in younger patients. This included normal-tension glaucoma, anterior ischaemic optic neuropathy, retinal vein occlusions, Susac syndrome and central serous chorioretinopathy. Hereditary diseases, such as Leber’s optic neuropathy or retinitis pigmentosa, were also associated with FS, and FS symptoms and sings occurred more frequent in patients with multiple sclerosis or with acute hearing loss. Further research should lead to a more concise definition of FS, a precise diagnosis and tools for recognizing people at risk for associated diseases. This may ultimately lead to more efficient and more personalised treatment.

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“…Störungen der Mikrozirkulation mit einem verminderten retinalen, choroidalen und retrobulbären Blutfluss wurden zudem bei Patienten mit Offenwinkelglaukom nachgewiesen [12][13][14][15][16]. Verminderte Pulsamplituden der Netzhautvenen weisen bei Glaukomen auf eine alterierte venöse Mikrozirkulation mit gestörtem Venenabfluss und erhöhtem intraluminalen Druck hin [98].…”

Section: Gefäßeunclassified

Fettstoffwechselstörungen und Glaukom

Jünemann

Huchzermeyer

Ręjdak³

et al. 2014

Klin Monatsbl Augenheilkd

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Zusammenfassung In der multifaktoriellen Pathogenese der glaukomat?sen Optikusatrophie spielen endotheliale Dysfunktion und vaskul?re Dysregulation eine Rolle. Dyslipid?mie als Risikofaktor f?r die endotheliale Dysfunktion ist sowohl mit der Glaukomerkrankung als auch mit kardiovaskul?rer Morbidit?t und Mortalit?t assoziiert. Ein m?glicher Mechanismus ist bei gegebener genetischer Disposition die additive Wirkung verschiedener Risikofaktoren f?r die endotheliale Dysfunktion, wie Dyslipid?mie, Rauchen, arterielle Hypertonie, Diabetes und Hyperhomozystein?mie. In dieser ?bersichtsarbeit wird die aktuelle Datenlage zur Assoziation zwischen Dyslipid?mie und Glaukomerkrankung dargelegt sowie eine m?gliche Rolle der Dyslipid?mie in der Pathogenese und Progression der Glaukomerkrankung erl?utert. Die Bedeutung exogener modifizierbarer Risikofaktoren f?r die Pr?vention und Therapie der Glaukomerkrankung sowie ihrer Neutralisierung durch eine ?nderung des Lebensstils, wie Gewichtsreduktion, Modifizierungen der Ern?hrung und gesteigerte k?rperliche Aktivit?t, wird diskutiert.

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Analyse der Venenbewegungen in der Netzhaut von Glaukompatienten

Abstract: Retinal veins in glaucoma eyes demonstrate lower pulse amplitudes than healthy eyes, indicating disturbance in venous outflow and increased intraluminal venous pressure.

Cited by 7 publications

References 18 publications

Central Retinal Venous Pressure in Eyes of Normal-Tension Glaucoma Patients with Optic Disc Hemorrhage

Central Retinal Venous Pressure in Eyes of Normal-Tension Glaucoma Patients with Optic Disc Hemorrhage

The discovery of the Flammer syndrome: a historical and personal perspective

Fettstoffwechselstörungen und Glaukom

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