Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from k-casein on platelet function

Abstract

A large number of similarities have previously been noted between the blood and milk clotting phenomena [Jollès, P. (1975) Mol. Cell. Biochem. 7, 73–85; Jollès, P. & Henschen, A. (1982) Trends Biochem. Sci. 7, 325–328]: some analogous features have also been found between fibrinogen and k‐casein. In this connection, the effect of a natural and a synthetic peptide derived from k‐casein on platelet function was studied: the undecapeptide Met‐Ala‐Ile‐Pro‐Pro‐Lys‐Lys‐Asn‐Gln‐Asp‐Lys (residues 106 → 116 of cow k‐casein) inhibited both aggregation of ADP‐treated platelets and binding of 125I‐fibrinogen to ADP‐treated platelets: its behaviour was similar to that of the structurally related C‐terminal dodecapeptide of human fibrinogen γ‐chain.

Structure, Sulfatide Binding Properties, and Inhibition of Platelet Aggregation by a Disabled-2 Protein-derived Peptide

“…Moreover, RGD peptides have low activity and poor stability in plasma (59). Milk-derived peptides, such as those from casein and lactoferrin (60,61), have been reported to show anti-thrombotic activity, although it is not known whether they can be effective in vivo. Here, we report that Dab2 SBM peptide exhibits anti-aggregatory activity comparable with that observed with the fibrinogen-derived RGDS peptide (Fig.…”

Peptides: Production, bioactivity, functionality, and applications

“…However, blood coagulation and clot formation are considered undesirable circumstances in some medical conditions and therefore, antithrombotic agents, especially natural ones, are favored. In this regard, bioactive peptides have been found to have antithrombotic effect (Jolles et al, 1986;Raha et al, 1988;Mazoyer et al, 1990;Chabance et al, 1995;Morimatsu et al, 1996;Shimizu et al, 2009). There are two types of antithrombotic agents: anticoagulants and antiplatelets.…”

Detailed peptide profiling of “Scotta”: from a dairy waste to a source of potential health-promoting compounds

“…The antimicrobial activity of peptide QVTSTVV should be further investigated, since the buffalo variant possesses an amino acid variation (V 167 -A). Moreover, an antithrombotic function was reported for the k-CN peptide MAIPPKKNQ f(105-113) (Jolles et al 1986). Kappa-CN fragments f(65-73) and f(105-113) had not been detected before in Scotta.…”