Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

“…Besides, the cytotoxic activities of isatin-arylsulfoanilide [30], isatin-4-piperazinylquinoline [31], isatin-benzoxazole [32], isatin-quinazoline-4(3H)-one [33] and isatinpyrazoline [34] hybrids were reported. Moreover, we reported the anticancer activity of two series of isatin-based hydrazones V and VI ( Figure 1) [35,36].…”

“…The present study is an extension of our ongoing efforts towards developing potent isatin-based anticancer agents [35,36,[45][46][47], utilizing a hybrid pharmacophore approach. In view of the previous findings, we decided to design and synthesize three different set of isatin-pyridine hybrids 5a-o, 8 and 11a-d (Figure 1), with the prime aim of developing potent anticancer agents.…”

“…Stirring was continued at the refluxing temperature for 1 h. The precipitate of hydrazone was filtered, washed with methanol, dried and recrystallized from the glacial acetic acid to give compounds 9a-d [36].…”

Crystal structure of methyl (Z)-2-(5-fluoro-2-oxoindolin-3-ylidene)hydrazine-1-carbodithioate, C10H8FN3OS2

“…Some derivatives have attracted much attentions because they are regarded as new anticancer agents [4][5][6][7]. Recently, our group synthesized two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one, which can non-covalently bind to DNA with high affinity and exhibit cytotoxicity against cancer cells by inducing apoptosis [8].…”

Some new indole–coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies

“…Amidst them, heterocycles with polycyclic ring system possess distinct rigid geometry displaying high functional specialization by orienting its substituents in three dimensional spaces, there by attracting great interest [2]. Indole is a bicyclic heterocyclic scaffold that find applications in medical therapy due to a variety of valuable biologic activities such as antiviral [3,4], antiinflammatory [5,6], anti-hyperlipidemic, antihypoglycemic, anti-hypertensive, anti-asthmatic, anti HIV [7], antidepressant [8] and notably anticancer [9][10][11][12][13][14][15] activity. Few marketed anticancer indole derivatives are vincristine, vinblastine, vinorelbine, vindesine, mitraphylline, cediranib and apaziquone [2].…”